Association of GST Genes Polymorphisms with Asthma in Tunisian Children

Chelbi, Hanène; Lachheb, Jihene; Ammar, Jamel; Hamzaoui, Kamel; Hamzaoui, A.

doi:10.1155/2007/19564

Cited by 51 publications

(42 citation statements)

References 36 publications

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“…In this study, we found that the frequencies of GSTP1 exon 5 genotypes in healthy controls were similar to those in Tunisia (Hanene et al, 2007), also close to those reported in European populations (Harries et al, 1997;Ryberg et al, 1997;van Lieshout et al, 1999;Rodríguez et al, 2005), but lower than Asiatic groups (Chan-Yeung et al, 2007). The different distribution in the 105Val allele between populations may be relevant to different GSTP1-metabolizing activities and to differences in susceptibility to specific exposure-induced diseases in different races.…”

Section: Discussionsupporting

confidence: 88%

“…The Val105/Val105 genotype distribution of GSTP1 in the present control group (10.43%) was similar to that in another Tunisian sample (10.7%) (Hanene et al, 2007), higher compared to Taiwanese (3%) and European-Americans (7%), but lower than in African-Americans (19%) (Watson et al, 1998). The difference in frequencies of genotype may be relevant to different enzyme-metabolizing activities and types of dominant functional enzymes against oxidative stress in different races.…”

Section: Discussionsupporting

confidence: 79%

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Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Lakhdar¹,

Denden²,

Knani³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the GST family, which is a group of phase II enzymes that catalyze the glutathione conjugation of many endogenous and exogenous electrophilic compounds, such as carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products. We conducted a case-control study to investigate genetic polymorphisms of this enzyme [exon 5 (Ile105Val) and exon 6 (Ala114Val)] in 234 unrelated COPD cases and 182 healthy controls from a Tunisian population. Genotyping was carried out using polymerase chain reaction and restriction fragment length polymorphism methods. GSTP1 Ala114/ Val114 and Val114/Val114 genotypes were not found in either patients or healthy controls. However, there were differences in the distribution of various exon 5 GSTP1 genotypes between COPD patients and healthy controls. GSTP1 Val105/Val105 was significantly more common in patients compared to controls (OR = 2.67; 95%CI = 1.45-4.92; P = 0.0013). Multivariate logistic regression analysis confirmed a significant relationship between the mutant genotype and COPD (OR = 2.58; 95%CI = 1.31-5.09; P = 0.026), after adjustment for classic risk factors. Analysis of variance showed no correlation between age, body-mass index, pack-years, percentage of predicted FEV1 values, and any of the GSTP1 genotypes. We conclude that subjects with GSTP1 Val105 allele are at higher risk of COPD.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 79%

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Lakhdar¹,

Denden²,

Knani³

et al. 2010

Genet. Mol. Res.

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“…When the distribution of the GSTM1 and GSTT1 null genotypes were compared between linguistic groups of the control subjects, different percentages were obtained and GSTT1 null genotypes was statistically different between the Afro-Asiatic and the Nilo-Saharan groups (P = 0.01). Difference in frequencies between Africans population is reported; Egyptians 15-29% (Abdel-Rahman, 1996;Hamdy et al, 2003), Tunisians 29% (Hanene et al, 2007) and Zimbabweans 26% (Masimirembwa, et al, 1998). generally speaking the GSTM1 frequency (10.3%) is close to sub-Saharan Africa range; Nigerians 22% (Zhao et al, 1994) and Zimbabweans 24% (Masimirembwa, et al, 1998).…”

Section: Drug Metabolizing Enzymesmentioning

confidence: 85%

Myeloid Leukemia: A Molecular Focus on Etiology and Risk Within Africa

Ibrahim¹,

Osman²

2011

Myeloid Leukemia - Basic Mechanisms of Leukemogenesis

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“…Primer sequences and restriction enzyme 8,20,21 used in the study for different polymorphisms are given in Supplementary Table S1.…”

Section: Genotypingmentioning

confidence: 99%

GST Polymorphisms and GST Enzyme Activity in Type 1 Myotonic Dystrophy

Agarwal¹

2015

JIG

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chain reaction; +/+/+, gstm1, gst1 and gstm3 present; -/-/-, gstm1, gstt1 and gstm3 absent; ile/val and ile/ile=heterozygous and homozygous status of GSTP1 IntroductionMyotonic dystrophy (DM) is an autosomal dominant, multisystem trinucleotide repeat disorder. Myotonic dystrophy is clinically heterogeneous and at the molecular level at least two types can be distinguished: DM type 1 (DM1; Steinert disease) and DM type 2 (DM2; proximal myotonic myopathy (PROMM) or Ricker syndrome). DM1 is the most common form of muscular dystrophy in adults with an estimated incidence of 1:8000.1 Two different mutations are responsible for DM: DM1 (OMIM #160900) is caused by a (CTG)n repeat expansion in the 3'-untranslated region of the DMPK gene located within chromosome band 19ql3.3 2,3 while DM2 (OMIM #602688) is caused by a large (CCTG)n repeat expansion in intron l of the CNBP gene at chromosome 3q21. 4,5 GSTs activity involves in the pathogenesis of DM1 because it contains polymorphic trinucleotide repeat.6 Human GSTs represent a large and diverse super family of enzymes, with at least 13 GST enzymes belonging to five different families: mu, theta, alpha, pi, and gamma. The GSTM1 & GSTM3, GSTT1 and GSTP1 belong to the GSTmu, GSTtheta, and GSTpi categories of enzymes respectively. Glutathione S-transferases (GSTs) are phase II detoxifying enzymes that catalyze a variety of reduced glutathione-dependent reactions with electrophilic substrates, including active metabolites of carcinogens. 7 In particular, GSTM1, GSTM3, GSTP1 and GSTT1 are involved in detoxification of active metabolites of several potential carcinogens such as benzo [a]pyrene and other polycyclic aromatic hydrocarbons, monohalomethanes and ethylene oxide.7-9 It also play an important role in the functioning of antioxidant defences through reactive oxygen species (ROS) metabolism, in the repairing of damaged ROS and in the detoxification of several xenobiotics. 7,10 The absence of GSTT1 and GSTM1 enzyme activities is caused by homozygous deletion of the respective genes (null genotypes). 11,12 In the GSTM3 gene, the GSTM3*A wild-type allele and the GSTM3*B variant allele have been described. 8 GSTM3*B contains a recognition motif for the YY1 transcription factor, which has been postulated to regulate gene expression. 13 It was suggested that GSTM3*A and GSTM3*B are expressed at different levels and could therefore confer different efficiencies in the metabolism of carcinogens and toxic compounds.14 In the GSTP1 gene, 2 variant alleles, GSTP1*B and GSTP1*C, have been detected in addition to the wild-type allele GSTP1*A.9 Both variant alleles have an A-to-G transition at nucleotide 313, causing a change of isoleucine (Ile) to valine (Val) at codon 105. The specific activity and affinity for electrophilic substrates is altered in the Val variant.9 It is therefore plausible that hereditary differences in the activities of these enzymes, due to genetic polymorphisms. 8,9,11,12 Different GSTs polymorphism has been studied in various malignancies.15-18 However, there ...

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Association of GST Genes Polymorphisms with Asthma in Tunisian Children

Cited by 51 publications

References 36 publications

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population

Myeloid Leukemia: A Molecular Focus on Etiology and Risk Within Africa

GST Polymorphisms and GST Enzyme Activity in Type 1 Myotonic Dystrophy

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