Association of growth performance and body conformational traits with BMP4 gene variation in Barki lambs

Ibrahim, A. H. M.

doi:10.1080/08977194.2019.1662417

Cited by 5 publications

(5 citation statements)

References 52 publications

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“…It has been reported that morphogenetic proteins (BMPs) have multiple roles in skeletal development, homeostasis and regeneration in mammals and livestock (Shimaski et al 1999), but very few traceable information are available regarding the association of BMP4 gene variants with body weight of indigenous goat breeds. In contrast to the current findings, significant associations of body weight and confirmational traits with BMP4 variants have been reported in goats (Fang et al 2009 and2010), sheep (Ibrahim 2019) andcattle et al 2010). In the current study, no significant association between body weight parameters and genotypes was recorded, but considering the important role of the BMP4 gene on muscle and bone growth, further study on a larger population can be done to establish the effect of the BMP4 gene on growth.…”

Section: Resultscontrasting

confidence: 99%

Evaluation of Bone Morphogenetic Protein-4 gene polymorphism for growth traits in Indian goat breeds

KHARE

Joshi

Thakur

et al. 2022

Indian J of Anim Sci

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The genetic improvement of production traits can be made through marker assisted selection using a candidategene approach. Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to thetransforming growth factor b (TGF-b) superfamily. This study aimed to detect the genetic polymorphism of BMP-4in different goat breeds by polymerase chain reaction-single strand confirmational polymorphism (PCR-SSCP) andassociation of polymorphic variants with growth traits. The amplified fragments of BMP4 gene of 380 bp size wereanalysed using SSCP in non-denaturing PAGE and the results showed the presence of two genotypes: AA (47-67%) and BB (33-53%) in Barbari, Sirohi and Black Bengal breed. The association of BMP-4 polymorphism withdifferent growth trait parameters showed non-significant effect of genotypes. However, some genotypes showednon-significant superiority over others. Further research on a large population is required to validate the role of theBMP-4 gene in goat growth traits.

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Section: Resultscontrasting

confidence: 99%

Evaluation of Bone Morphogenetic Protein-4 gene polymorphism for growth traits in Indian goat breeds

KHARE

Joshi

Thakur

et al. 2022

Indian J of Anim Sci

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“…Despite the tendency of the sex of the animal to influence growth traits in sheep [37,42], these effects were not significant in our results for BW. This may be due to the limited sample size population used in the present study.…”

Section: Discussioncontrasting

confidence: 92%

Genetic variations in the Myostatin gene affecting growth traits in sheep

et al. 2021

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Background and Aim: Sheep productivity in developing countries is crucial, as this animal is an essential source of meat and wool. Myostatin (MSTN) plays an important role in the regulation of muscle mass through the regulation of muscle growth, differentiation, and regeneration. The present study sought to investigate genetic variation in the first intron of the MSTN gene and the association of variants with growth traits in major sheep breeds in Egypt (Barki, Ossimi, and Rahmani) and Saudi Arabia (Najdi) using polymerase chain reaction (PCR) and sequencing. Materials and Methods: Blood samples were collected, and DNA was extracted from 75 animals. A 386 bp fragment in the first intron of the MSTN gene was amplified using PCR. Polymorphic sites were detected using direct sequencing and then correlated with growth traits using a general linear model. Results: Sequence analysis of the first intron of MSTN gene identified six single-nucleotide polymorphisms (SNPs) in the studied breeds. Four mutual SNPs were determined: c.18 G>T, c.241 T>C, c.243 G>A, and c.259 G>T. In addition, two SNPs c.159 A>T and c.173 T>G were monomorphic (AA and TT, respectively) in the Ossimi, Rahmani, and Najdi breeds and polymorphic in the Barki breed. The association analysis revealed that the c.18 G>T and c.241 C>T significantly associated (p<0.05) with birth weight and average daily weight gain, respectively. Conclusion: Our results strongly support MSTN as a candidate gene for marker-assisted selection in sheep breeding programs. Furthermore, the identified variants may be considered as putative markers to improve growth traits in sheep.

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“…This suggestion could be implied here in the TLR4 variants to achieve the optimum progress in dairy sheep products based on the results of the current report. Recent reports refer to the importance of estimating the additive and/or the dominance genetic effect of specific variants on the economic traits of livestock [28,29]. The significant additive effects of the TLR4 variants identified here in Barki ewes on FP, PP, LP, and TSP suggested that these effects should be considered in genetic improvement of milk production in Barki sheep.…”

Section: Discussionmentioning

confidence: 78%

A missense mutation in the coding region of the toll-like receptor 4 gene affects milk traits in Barki sheep

Sallam

2021

Anim Biosci

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Objective: Milk production is one of the most desirable traits in livestock. Recently, the toll-like receptor (TLR) has been identified as a candidate gene for milk traits in cows. So far, there is no information concerning the contribution of this gene in milk traits in sheep. This study was designed to investigate the TLR 4 gene polymorphisms in Barki ewes in Egypt and then correlate that with milk traits in order to identify potential single nucleotide polymorphisms (SNPs) for these traits in sheep.Methods: A part of the ovine TLR 4 gene was amplified in Barki ewes, to identify the SNPs. Consequently; Barki ewes were genotyped using polymerase chain reaction-single strand conformation polymorphism protocol. These genotypes were correlated with milk traits, which were the daily milk yield (DMY), protein percentage (PP), fat percentage (FP), lactose percentage, and total solid percentage (TSP).Results: Age and parity of the ewe had a significant effect (p<0.05 or p<0.01) on DMY, FP, and TSP. The direct sequencing identified a missense mutation located in the coding sequence of the gene (rs592076818; c.1710C>A) and was predicted to change the amino acid sequence of the resulted protein (p.Asn570Lys). The association analyses suggested a significant effect (p<0.05) of the TLR genotype on the FP and PP, while the DMY tended to be influenced as well (p = 0.07). Interestingly, the presence of the G allele tended to increase the DMY (+40.5 g/d) and significantly (p<0.05 or p<0.01) decreased the FP (–1.11%), PP (–1.21%), and TSP (–7.98%).Conclusion: The results of this study suggested the toll-like receptor 4 (TLR4) as a candidate gene to improve milk traits in sheep worldwide, which will enhance the ability to understand the genetic architecture of genes underlying SNPs that affect such traits.

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Association of growth performance and body conformational traits with BMP4 gene variation in Barki lambs

Cited by 5 publications

References 52 publications

Evaluation of Bone Morphogenetic Protein-4 gene polymorphism for growth traits in Indian goat breeds

Evaluation of Bone Morphogenetic Protein-4 gene polymorphism for growth traits in Indian goat breeds

Genetic variations in the Myostatin gene affecting growth traits in sheep

A missense mutation in the coding region of the toll-like receptor 4 gene affects milk traits in Barki sheep

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