Association of Graft Neutrophil Sequestration With Delayed Graft Function in Clinical Renal Transplantation

Abstract

Neutrophils are activated and sequestered in the reperfused graft during clinical renal transplantation. Neutrophil sequestration is a powerful independent factor explaining the incidence of DGF.

Long-term outcome of ATG vs. Basiliximab induction

“…A prompt decrease in the white cell count was noted in the ATG group immediately after application. Others have speculated that this phenomenon may have a positive impact on the onset of delayed graft function since DGF is associated with leukocyte sequestration, and immediate depletion would prevent the onset of DGF [16,29,30]. We could not confirm these findings, because the rate of DGF in our study was comparable in both groups.…”

Renal Transplantation Normalized Hydrogen Peroxide Production of Neutrophils within the First Day

“…They observed neutrophil infiltration after reperfusion in 29 of 55 (53%) CAD allografts, whereas no increase in neutrophil infiltration was detected in any of the analyzed LRD allografts. Furthermore, the presence of neutrophils in the glomeruli of CAD allografts was significantly associated with delayed graft function [23]. As expected we found delayed graft function in 4 patients of the CAD group and there was no graft failure in the LRD group.…”

Activated Protein C Reduces Graft Neutrophil Activation in Clinical Renal Transplantation

“…In renal transplantation, we have recently found graft neutrophil sequestration as the most powerful predictor of delayed graft function (DGF), surpassing even cold ischemia time in patients not receiving anti‐thymocyte globulin (ATG, Fresenius AG, Bad Homburg, Germany) prior to reperfusion (11). Motivated by our previous results in clinical liver transplantation, here we investigated the role of protein C pathway and its relation to concomitant neutrophil activation in clinical renal transplantation.…”