Association of Glycemic Control with Risk of Erectile Dysfunction in Men with Type 2 Diabetes

Abstract

Introduction Improvement in glycemic control is likely to reduce the risk of diabetic complication, while its effect on erectile dysfunction (ED) remains unclear. Aim The aim of this study was to evaluate the association of glycemic control with risk of ED in type 2 diabetics. Methods A self-administered questionnaire containing Sexual Health Inventory for Men was obtained from 792 subjects with type 2 diabetes at our institution. Clinical data were obtained through chart review. Main Outcome Measures The contribution of glycemic control assessed by glycated hemoglobin (HbA1c) level as well as age, duration of diabetes, hypertension (HT), dyslipidemia, and cigarette smoking to risk of ED was evaluated. Results Of 792 subjects, 83.6% reported having ED and 43.2% had severe ED. HbA1c level (%) adjusted for age and duration of diabetes was significantly associated with ED (OR 1.12, 95% CI: 1.01–1.25). None of HT, dyslipidemia, and cigarette smoking was a significant risk factor for ED after adjusted for age and duration of diabetes. HbA1c level, age, and duration of diabetes were significant independent risk factors for ED among the younger group (age ≤ 60 years), and only age and duration of diabetes were independent risk factors among the older group (age > 60 years). For the risk of severe ED, compared with no and mild to moderate ED, HbA1c level, duration of diabetes, and HT were independent risk factors among the younger group, and only age was an independent factor among the older group. Conclusions Better glycemic control probably would reduce the prevalence of ED and its severity among the younger men with type 2 diabetes. For the older group, aging was the major determinant for ED risk among this population with type 2 diabetes.

Erectile function in men with diabetes type 2: correlation with glycemic control

“…These data suggest a possible benefit of tight glycemic control in the prevention of erectile dysfunction. Our results were also consistent with the results of Lu et al, 16 who evaluated the association of glycemic control with risk of ED in type 2 diabetics. A selfadministered questionnaire was obtained from 792 subjects with type 2 diabetes.…”

“…Results obtained were classified as described by Resen et al (1997) 7 as follows: good response, (420); fair response (15)(16)(17)(18)(19)(20); and poor response (o15).…”

Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men

“…However, the treatment rate for dyslipidemia is low in Taiwan. 40 Even if lipid-lowering agents were used, it often coexisted with HT and DM and therefore, adjustment of HT and DM was supposed to have the same effect as adjusting for dyslipidemia.…”

Erectile dysfunction, diabetes and cardiovascular risk

“…However, for patients aged >60 years, only age and duration of diabetes were independent predictors of severe ED. 20 In patients with diabetes, the severity of ED has been linked to the number of circulating endothelial microparticles. 21 The medications that patients are receiving for treatment of diabetes and their complications may influence ED.…”

“…19,20 Lu et al conducted a study involving 792 men, of whom 83.6% had some degree of ED, including 43% with serious ED. 20 The study showed that, even after controlling for age and duration of diabetes, there was an association between glycated haemoglobin levels (HbA1c) and ED (OR 1.12, 95% CI 1.01 to 1.25). The authors also performed subgroup analysis to investigate the association between age and severe ED.…”