Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Tesovnik, Tine; Kovač, Jernej; Hovnik, Tinka; Dovč, Klemen; Bratina, Nataša; Battelino, Tadej; Podkrajšek, Katarina Trebušak

doi:10.1001/jamapediatrics.2018.1175

Cited by 15 publications

(10 citation statements)

References 6 publications

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“…That has proved beneficial in our previous studies focusing on telomere attrition in type 1 diabetes. Our initial study in pediatric patients did not confirm the association between TL and glycemic control (Tesovnik et al, 2015 ) contrary to the later retrospective longitudinal study (Tesovnik et al, 2018 ). Furthermore, integration of the clinical, genomic, and biochemical data from longitudinal studies in a multivariable predictive model may be beneficial in an attempt to identify additive biomarkers influencing the development and/or progression of AD and PD.…”

Section: Discussioncontrasting

confidence: 72%

Telomere Attrition in Neurodegenerative Disorders

Levstek

Kozjek

Dolžan

et al. 2020

Front. Cell. Neurosci.

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Telomere attrition is increased in various disorders and is therefore a potential biomarker for diagnosis and/or prognosis of these disorders. The contribution of telomere attrition in the pathogenesis of neurodegenerative disorders is yet to be fully elucidated. We are reviewing the current knowledge regarding the telomere biology in two common neurodegenerative disorders, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Furthermore, we are discussing future prospective of telomere research in these disorders. The majority of studies reported consistent evidence of the accelerated telomere attrition in AD patients, possibly in association with elevated oxidative stress levels. On the other hand in PD, various studies reported contradictory evidence regarding telomere attrition. Consequently, due to the low specificity and sensitivity, the clinical benefit of telomere length as a biomarker of neurodegenerative disease development and progression is not yet recognized. Nevertheless, longitudinal studies in large carefully selected cohorts might provide further elucidation of the complex involvement of the telomeres in the pathogenesis of neurodegenerative diseases. Telomere length maintenance is a complex process characterized by environmental, genetic, and epigenetic determinants. Thus, in addition to the selection of the study cohort, also the selection of analytical methods and types of biological samples for evaluation of the telomere attrition is of utmost importance.

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Section: Discussioncontrasting

confidence: 72%

Telomere Attrition in Neurodegenerative Disorders

Levstek

Kozjek

Dolžan

et al. 2020

Front. Cell. Neurosci.

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“…Reported associations between telomere lengths and diabetes have previously mainly dealt with increased comorbidity and mortality [11][12][13] . Very high HbA1c levels were recently associated with telomere attrition in a longitudinal study of children 30 . We observed a weak inverse association between LTLs and HbA1c, and the significant association between LTLs and the presence of long-term type 1 diabetes mellitus was not present when HbA1c levels were adjusted for, indicating its possible impact.…”

Section: Discussionmentioning

confidence: 98%

Reduced leukocyte telomere lengths and sirtuin 1 gene expression in long‐term survivors of type 1 diabetes: A Dialong substudy

Opstad

Berg

Holte

et al. 2020

J of Diabetes Invest

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Aims/Introduction: The shortening of leukocyte telomere length with age has been associated with coronary disease, whereas the association with type 1 diabetes is unclear. We aimed to explore telomere lengths in diabetes patients with regard to coronary artery disease, compared with healthy controls. The longevity factors sirtuin 1 and growth-differentiating factor 11 were investigated accordingly. Materials and Methods: We carried out a cross-sectional study of 102 participants with long-term type 1 diabetes and 75 controls (mean age 62 and 63 years, respectively), where 88 cases and 60 controls without diagnosed coronary artery disease completed computed tomography coronary angiography. Telomere lengths and gene expression of sirtuin 1 and growth-differentiating factor 11 were quantified in leukocytes. Results: Telomere lengths and sirtuin 1 were reduced in diabetes patients versus controls, medians (25th to 75th percentiles): 0.97 (0.82-1.15) versus 1.08 (0.85-1.29) and 0.88 (0.65-1.14) vs 1.01 (0.78-1.36), respectively, adjusted P < 0.05, both. Previous coronary artery disease in diabetes patients (n = 15) was associated with lower sirtuin 1 and growth-differentiating factor 11 messenger ribonucleic acid expression (adjusted P < 0.03, both). In the combined diabetes and control group, previous artery coronary disease (n = 18) presented with significantly shorter telomeres (adjusted P = 0.038). Newly diagnosed obstructive coronary artery disease, defined as >50% stenosis, was not associated with the investigated variables. Conclusions: Long-term type 1 diabetes presented with reduced telomeres and sirtuin 1 expression, with additional reduction in diabetes patients with previous coronary artery disease, showing their importance for cardiovascular disease development with potential as novel biomarkers in diabetes and coronary artery disease.

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“…The role of GV as a risk factor for developing complications of diabetes remains controversial, however, several reports associate GV with oxidative stress and damage to susceptible organs [15,16] and chromosomes [17]. Consequently, preventing excessive glucose fluctuations early in the disease course could provide long-term benefit for children.…”

Section: Discussionmentioning

confidence: 99%

Continuous glucose monitoring use and glucose variability in pre-school children with type 1 diabetes

Dovč

Cargnelutti

Sturm

et al. 2019

Diabetes Research and Clinical Practice

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The objective of this nationwide population-based cohort study was to evaluate the correlation between continuous glucose monitoring (CGM) use and glucose variability in pre-schoolers with type 1 diabetes. Methods: We analysed data from the Slovenian National Registry. The primary endpoint was the difference in glucose variability between periods, during which participants were using CGM and periods, during which CGM was not used, over 5 years. Results: A total of 40 children <8 years old were followed for an estimated observational period of 116 patient/years. Mean age at CGM initiation was 3.5 (±1.7) years. Both standard deviation of mean glucose [3.6 mmol/L (3.2-3.9) with CGM and 4.3 mmol/L (3.8-4.7) without CGM, p < 0.001] and coefficient of variation [44.0% (40.4-47.0) with CGM and 46.1% (42.3-49.4) without CGM, p = 0.021] were lower during the periods, when CGM was used. Frequent CGM use (>5 days/week) was associated with a 0.4% [4.4 mmol/mol] reduction in glycated haemoglobin level (7.6% compared to 7.2%, p = 0.047). Conclusions: Our results indicate that the use of CGM was associated with reduced glucose variability during a 5 year follow-up period among pre-schoolers with type 1 diabetes.

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Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

Abstract: Stoddard SA, Zimmerman MA, Bauermeister JA. Thinking about the future as a way to succeed in the present: a longitudinal study of future orientation and violent behaviors among African American youth.

Cited by 15 publications

References 6 publications

Telomere Attrition in Neurodegenerative Disorders

Telomere Attrition in Neurodegenerative Disorders

Reduced leukocyte telomere lengths and sirtuin 1 gene expression in long‐term survivors of type 1 diabetes: A Dialong substudy

Continuous glucose monitoring use and glucose variability in pre-school children with type 1 diabetes

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