Association of Glycated Haemoglobin With Lipid Profile in Type 2 Diabetes Patients

Abstract

BACKGROUND Diabetes mellitus is one of the common metabolic disorders. It has become a global pandemic with prevalence in both developing and developed countries. Glycated haemoglobin (HbA1c) is used to assess long-term glycaemic control. It indicates the mean plasma glucose level over three months. Patients with type 2 diabetes have an increased prevalence of lipid abnormalities. Dyslipidaemia increases the risk of cardiovascular and cerebrovascular attacks owing to atherosclerosis, controlling hyperglycaemia reduces HbA1c levels and reduces risk of complications resulting due to hyperglycaemia. This study was done to find any association between HbA1c and lipid profile, and thereby HbA1c can be used for screening high risk patients to diagnose dyslipidaemia and timely intervention can avoid complication. MATERIALS AND METHODS This is a descriptive study comprising of 80 non-hypertensive patients with diabetes aged 30-60 yrs. attending OPD Department at Mahavir Institute of Medical Sciences with no history of cardiovascular, thyroid, renal or any other organ disorders. The patients were classified into two groups depending on their glycated haemoglobin (HbA1c) as controlled (A1c < 7%) and uncontrolled (A1c >7%) as per ADA guidelines. RESULTS The study included 80 patients. They were further subdivided into two groups based on HbA1c (Group I < 7% and Group II > 7%). Mean ± S.D. of fasting glucose (mg/dL), total cholesterol (mg/dL), triglycerides (mg/dL), LDL-C (mg/dL), VLDL (mg/dL) between