Association of glutathione S-transferase M1 and T1 gene polymorphisms and oxidative stress markers in preterm labor

Mustafa, Md.; Pathak, Rahul; Ahmed, Tanzeel; Ahmed, Rafat S.; Tripathi, Anil Kumar; Guleria, Kiran; Banerjee, Basu Dev

doi:10.1016/j.clinbiochem.2010.06.018

Cited by 38 publications

(40 citation statements)

References 32 publications

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“…Study of Kamath et al [21] was restricted to the estimation of the lipid and protein oxidation markers in maternal and cord blood of 13 FGR cases of variable etiologies and 15 controls between 33-39 weeks, the results of which were similar to this study. Previous studies from our lab have also reported significant association between increased oxidative stress and adverse pregnancy outcomes [22,23]. These studies have shown that increased oxidative stress may be associated with environmental chemicals and genetic polymorphism.…”

Section: General Physical Examinationmentioning

confidence: 58%

Assessment of Redox Imbalance in Idiopathic Fetal Growth Restricted Pregnancies

Goel¹,

Banerjee²,

Pathak³

et al. 2012

Reprod Sys Sexual Disorders

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Background: Fetal growth restriction (FGR) is one of the most significant causes of perinatal morbidity and mortality. The known causes are poor maternal nutrition, hypertensive disorders complicating pregnancy, maternal medical disorders (multiple pregnancy, congenital fetal malformations), and lifestyle influences. However, in vast majority of cases, the cause still remains unknown. Recent studies have suggested the role of oxidative stress in the pathophysiology of FGR. The aim of this study was to evaluate non-enzymatic oxidative stress biomarkers in maternal and cord blood of idiopathic FGR cases.

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Section: General Physical Examinationmentioning

confidence: 58%

Assessment of Redox Imbalance in Idiopathic Fetal Growth Restricted Pregnancies

Goel¹,

Banerjee²,

Pathak³

et al. 2012

Reprod Sys Sexual Disorders

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“…Some researchers have found the opposite association, in persons with kidney disease and in women in labor (47)(48)(49). Others have not found significant associations of malondialdehyde with GSTM1-0 or GSTT1-0 or with the combination (26,27,50,51).…”

Section: Discussionmentioning

confidence: 89%

Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1

Block¹,

Shaikh²,

Jensen³

et al. 2011

The American Journal of Clinical Nutrition

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“…A recent study from our laboratory has also demonstrated the role of GST polymorphism in the development of oxidative stress in preterm labor cases. 18 This study was designed to investigate the role of the GST polymorphism in determining variation in susceptibility of individuals to CKD and to pinpoint the probable underlying mechanism.…”

Section: Introductionmentioning

confidence: 99%

Association of glutathioneS-transferaseM1andT1gene polymorphism with oxidative stress in diabetic and nondiabetic chronic kidney disease

et al. 2010

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Background and Objective: Glutathione S-transferases (GSTs) belong to a family of ubiquitous and multifunctional enzymes that work as one of the endogenous antioxidants in our body. This study was designed to look into the association of GST polymorphism with oxidative stress in both diabetic and nondiabetic chronic kidney disease (CKD). Design and Methods: Three groups of patients (50 in each): diabetics without CKD (DM), diabetic CKD (DM-CKD), and nondiabetic CKD (NDM-CKD) and 50 age-and sex-matched healthy controls were recruited. Genotyping was done for GSTM1 and GSTT1 genes using a multiplex polymerase chain reaction. Serum GST and malondialdehyde (MDA) as a marker of oxidative stress were measured spectrophotometrically. Results: Based on genotyping, subjects were categorized as GSTM1+/GSTT1+, GSTM1-/GSTT1+, GSTM1+/GSTT1-, and GSTM1-/GSTT1-. Serum GST levels were lower among subjects with deletion in one/both GST genes, whereas MDA levels were found to be correspondingly raised. A negative correlation for MDA versus GST levels was observed among genotypes with one/both gene deletions. Presence of GSTM1+/GSTT1-and GSTM1-/GSTT1-was significantly higher among patients with CKD in both diabetics and nondiabetics. Interpretations and Conclusions: GSTM1 and GSTT1 deletions singly or together were associated with lower GST levels and higher oxidative stress in both diabetic and nondiabetic CKD. Interestingly, GSTT1 deletion appears to be associated with both diabetic and nondiabetic CKD irrespective of the GSTM1 status.

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Association of glutathione S-transferase M1 and T1 gene polymorphisms and oxidative stress markers in preterm labor

Cited by 38 publications

References 32 publications

Assessment of Redox Imbalance in Idiopathic Fetal Growth Restricted Pregnancies

Assessment of Redox Imbalance in Idiopathic Fetal Growth Restricted Pregnancies

Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1

Association of glutathioneS-transferaseM1andT1gene polymorphism with oxidative stress in diabetic and nondiabetic chronic kidney disease

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