Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population

Bid, Hemant K.; Konwar, Rituraj; Saxena, M. C.; Chaudhari, Paresh; Agrawal, CG; Banerjee, Monisha

doi:10.4103/0022-3859.68633

Cited by 85 publications

(39 citation statements)

References 33 publications

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“…The majority of case control studies of GSTM1 and GSTT1 null genotypes have reported risk associations with disease [26,27]. The frequency of the GSTM1 null genotype in our study was 38.61%; it is little lower than reported in other populations (Egyptian 58.62%, Dubai 57.5%, North Indian 54.00%) [28–30]. The frequency of the GSTTI null genotype was 7.92% in T2DM patients, which is lower when compared to the Dubai (60.0%) and Egyptian (35.0%) populations [7,29].…”

Section: Discussioncontrasting

confidence: 57%

Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India

Raza

Abbas

Ahmad

et al. 2014

Balkan Journal of Medical Genetics

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Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world and India has the world’s largest number of diabetic subjects. The present study was carried out to investigate the association of glutathione-S-transferase (GSTM1, GSTT1) and fat mass and obesity associated (FTO) gene polymorphisms with T2DM patients and controls, and its role in increasing the susceptibility to T2DM. A total of 198 subjects (101 T2DM patients and 97 controls) participated in this study. GSTM1, GSTT1 and FTO gene polymorphisms in the patients and controls were evaluated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). We observed significant association of GSTM1 positive (p = 0.046) and GSTM1 null (p = 0.046) genotypes with T2DM, while no significant association was found with the FTO gene polymorphism in our study. It seems that the GSTM1 gene polymorphism can be a predictive marker for early identification of a population at risk of T2DM. The potential role of GST and FTO gene polymorphisms as a marker of susceptibility to T2DM needs further studies in a larger number of patients.

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Section: Discussioncontrasting

confidence: 57%

Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India

Raza

Abbas

Ahmad

et al. 2014

Balkan Journal of Medical Genetics

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“…No association was found between GST polymorphisms and BMI in Indian diabetic patients with null and positive GST genotypes. 11,32 Similarly, in Korean schizophrenic patients, no association was observed between GST polymorphisms and druginduced weight gain. 12 In view of these results, it can be concluded that GST polymorphisms are not associated with a higher BMI among hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that GST polymorphisms were not associated with BMI in diabetic North Indians or with weight gain in schizophrenic Koreans. 11,12 Since there is a close link between hypertension and obesity, this study sought to investigate the association of ACE and GST gene polymorphisms with BMI among a selected group of hypertensive North Indians.…”

mentioning

confidence: 99%

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Rizvi

Raza

Siddiqi

et al. 2015

SQUMJ

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abstract:Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era's Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m 2 ) or high (≥25 kg/m 2 ) BMI. The third group consisted of 125 age-, gender-and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. Results: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. Conclusion: ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.

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“…Although, high intraocular pressure (IOP) is recognized as being the main risk factor, the pathophysiology of POAG is considered multifactorial and multiple theories have been issued: mechanical damage due to high IOP, vascular dysregulation, altered intracranial pressure dynamics, glutamate excitotoxicity, nitric oxide dysregulation, astrocite reactivation, extracellular matrix remodelling, mutations in specific genes, changes in the mitochondrial genome, blood-retinal barrier breakdown and secondary low-grade inflammation, toxic effects and oxidative damage caused by reactive oxygen species (ROS) (3,10).…”

Section: To the Editormentioning

confidence: 99%

Letter to the Editor: Gluthathion S-transferase M1 and T1 polymorpisms in a group of Romanian glaucoma patients

Ster

Petrisor

Stan

et al. 2015

Revista Romana De Medicina De Laborator

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Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population

Cited by 85 publications

References 33 publications

Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India

Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Letter to the Editor: Gluthathion S-transferase M1 and T1 polymorpisms in a group of Romanian glaucoma patients

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