Association of Geography and Ambient Air Pollution with Urine Metal Concentrations in Six US Cities: The Multi-Ethnic Study of Atherosclerosis

Pang, Yuanjie; Jones, Miranda R.; Téllez-Plaza, María; Güallar, Eliseo; Vaidya, Dhananjay; Post, Wendy S.; Kaufman, Joel D.; Delaney, Joseph A.; Navas‐Acien, Ana

doi:10.3390/ijerph13030324

Cited by 14 publications

(5 citation statements)

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“…Another interesting area of future research is the role of joint exposures in atherosclerosis. It is important to evaluate mixtures of metals as metals co-occur together [154, 155]. While several of the retrieved studies adjusted the regression models for other metals, statistical methods to comprehensively tackle mixtures of compounds are needed.…”

Section: General Discussion and Needs For Future Epidemiologic Researchmentioning

confidence: 99%

Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium

Nigra

Ruiz-Hernandez

Redón

et al. 2016

Curr Envir Health Rpt

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126

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Published systematic reviews concluded that there is moderate to strong evidence to infer a potential role of lead and cadmium, widespread metal exposures, as cardiovascular risk factors. For other non-essential metals, the evidence has not been appraised systematically. Our objective was to systematically review epidemiologic studies on the association between cardiovascular disease in adults and the environmental metals antimony, barium, chromium, nickel, tungsten, uranium, and vanadium. We identified a total of 4 articles on antimony, 1 on barium, 5 on chromium, 1 on nickel, 4 on tungsten, 1 on uranium and 0 on vanadium. We concluded that the current evidence is not sufficient to inform on the cardiovascular role of these metals because the small number of studies. Few experimental studies have also evaluated the role of these metals in cardiovascular outcomes. Additional epidemiologic and experimental studies, including prospective cohort studies, are needed to understand the role of metals, including exposure to metal mixtures, in cardiovascular disease development.

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Section: General Discussion and Needs For Future Epidemiologic Researchmentioning

confidence: 99%

Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium

Nigra

Ruiz-Hernandez

Redón

et al. 2016

Curr Envir Health Rpt

Self Cite

126

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“…32 Urinary tungsten levels have been associated with PM 2.5 previously in MESA. 33 Some prior but limited evidence has related tungsten with cardiovascular outcomes. In NHANES, urinary tungsten levels were associated with stroke prevalence, 34 composite cardiovascular and cerebrovascular disease, 35 and higher self-reported CVD.…”

Section: Discussionmentioning

confidence: 99%

Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA)

McGraw,

Schilling,

Glabonjat

et al. 2023

Preprint

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ObjectiveGrowing evidence indicates that exposure to metals are risk factors for cardiovascular disease (CVD). We hypothesized that higher urinary levels of metals with prior evidence of an association with CVD, including non-essential (cadmium, tungsten, and uranium) and essential (cobalt, copper, and zinc) metals are associated with baseline and rate of change of coronary artery calcium (CAC) progression, a subclinical marker of atherosclerotic CVD.MethodsWe analyzed data from 6,418 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) with spot urinary metal levels at baseline (2000-2002) and 1-4 repeated measures of spatially weighted coronary calcium score (SWCS) over a ten-year period. SWCS is a unitless measure of CAC highly correlated to the Agatston score but with numerical values assigned to individuals with Agatston score=0. We used linear mixed effect models to assess the association of baseline urinary metal levels with baseline SWCS, annual change in SWCS, and SWCS over ten years of follow-up. Urinary metals (adjusted to µg/g creatinine) and SWCS were log transformed. Models were progressively adjusted for baseline sociodemographic factors, estimated glomerular filtration rate, lifestyle factors, and clinical factors.ResultsAt baseline, the median and interquartile range (25th, 75th) of SWCS was 6.3 (0.7, 58.2). For urinary cadmium, the fully adjusted geometric mean ratio (GMR) (95%Cl) of SWCS comparing the highest to the lowest quartile was 1.51 (1.32, 1.74) at baseline and 1.75 (1.47, 2.07) at ten years of follow-up. For urinary tungsten, uranium, and cobalt the corresponding GMRs at ten years of follow-up were 1.45 (1.23, 1.71), 1.39 (1.17, 1.64), and 1.47 (1.25, 1.74), respectively. For copper and zinc, the association was attenuated with adjustment for clinical risk factors; GMRs at ten years of follow-up before and after adjustment for clinical risk factors were 1.55 (1.30, 1.84) and 1.33 (1.12, 1.58), respectively, for copper and 1.85 (1.56, 2.19) and 1.57 (1.33, 1.85) for zinc.ConclusionHigher levels of cadmium, tungsten, uranium, cobalt, copper, and zinc, as measured in urine, were associated with subclinical CVD at baseline and at follow-up. These findings support the hypothesis that metals are pro-atherogenic factors.CLINICAL PERSPECTIVEWhat is new?Urinary levels of non-essential (cadmium, tungsten, uranium) and essential metals (cobalt, copper, zinc) are associated with coronary artery calcification at baseline and at ten years of follow up in a diverse US sample.What are the clinical implications?Reductions in environmental metal exposure may improve cardiovascular health.Dietary and chelation interventions to reduce metals in the body may improve CVD outcomes.

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“…MESA Air investigators found a positive association of PM 2.5 levels with urinary tungsten and also some evidence of an association with urinary uranium but did not see any relationship to urinary cadmium or antimony. 22 MESA Air researchers also found a moderate correlation between air pollution and noise. 23 …”

Section: B Exposure Assessment / Air Pollution Modelingmentioning

confidence: 98%

Advances in Understanding Air Pollution and CVD

Kaufman

Spalt

Curl

et al. 2016

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The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) leveraged the platform of the MESA cohort into a prospective longitudinal study of relationships between air pollution and cardiovascular health. MESA Air researchers developed fine-scale, state-of-the-art air pollution exposure models for the MESA Air communities, creating individual exposure estimates for each participant. These models combine cohort-specific exposure monitoring, existing monitoring systems, and an extensive database of geographic and meteorological information. Together with extensive phenotyping in MESA—and adding participants and health measurements to the cohort—MESA Air investigated environmental exposures on a wide range of outcomes. Advances by the MESA Air team included not only a new approach to exposure modeling but also biostatistical advances in addressing exposure measurement error and temporal confounding. The MESA Air study advanced our understanding of the impact of air pollutants on cardiovascular disease and provided a research platform for advances in environmental epidemiology.

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Association of Geography and Ambient Air Pollution with Urine Metal Concentrations in Six US Cities: The Multi-Ethnic Study of Atherosclerosis

Cited by 14 publications

References 32 publications

Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium

Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium

Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA)

Advances in Understanding Air Pollution and CVD

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