Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population

Abstract

Numerous studies have implicated the Wnt pathway in the development and progression of myocardial infarction (MI); however, there are very few investigations addressing the effects of polymorphisms in the Wnt pathway genes on MI susceptibility. We investigated the possible correlation between genetic variations in Wnt pathway genes and MI risk. Three polymorphisms (rs7832767 C > T in SFRP1 gene, rs2293303 C > T in CTNNB1 gene, rs16893344 C > T in WISP1 gene) were finally selected and genotyped in 465 MI patients and 485 healthy controls, using the PCR-RFLP method. We found that the SFRP1 rs7832767 variant allele (T) was associated with a significantly increased risk of MI [TT vs. CC: adjusted odds ratio (AOR) = 3.13, 95% CI = 1.78-5.51; CT/TT vs. CC: AOR = 1.53, 95% CI = 1.12-2.08; TT vs. CC/CT: AOR = 2.87, 95% CI = 1.66-4.97)]. The significant association with MI risk was also found for the CTNNB1 rs2293303 (CT vs. CC: AOR = 3.48, 95% CI = 2.28-5.33; TT vs. CC: AOR = 7.37, 95% CI = 2.08-26.16; CT/TT vs. CC: AOR = 3.72, 95% CI = 2.46-5.62; TT vs. CC/CT: AOR = 5.52, 95% CI = 1.58-19.28), and WISP1 rs16893344 polymorphisms (CT vs. CC: AOR = 2.43, 95% CI = 1.70-3.47; TT vs. CC: AOR = 5.17, 95% CI = 1.85-14.41; CT/TT vs. CC: AOR = 2.58, 95% CI = 1.83-3.66; TT vs. CC/CT: AOR = 3.88, 95% CI = 1.41-10.64). The associations remain significant in stratified analysis by demographic and clinical characteristics of participants, with few exceptions. Our study provided the first evidence of the association between polymorphisms in the Wnt pathway genes and MI susceptibility in Chinese Han population. Epidemiological studies with larger samples and functional analyses are warranted to further verify our results.

RETRACTED: MicroRNA-494 Inhibits the LRG1 Expression to Induce Proliferation and Migration of VECs in Rats following Myocardial Infarction

“…Another study also concluded that the migratory machinery of cells was associated with LRG1, because their activities were altered as observed in their performance within the non-canonical TGF-β signaling pathway 12 . Compelling evidence has identified the involvement of the Wnt signaling pathway in MI,13, 14 and that it was activated in MI as a potential therapeutic target 14, 15, 16. The Wnt signaling pathway is known to serve as a stem cell pathway, which is critical for embryogenesis and the transcription of downstream members of the pathway 17 .…”

Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma susceptibility

“…However, Chen et al [ 22 ] indicated that lung cancer patients carrying the T allele of the WISP1 rs16893344 polymorphism may have an increased risk of lung cancer. Tao et al also showed that WISP1 rs16893344 C > T polymorphisms significantly increased myocardial infarction risk [ 39 ]. These results demonstrate that the various WISP1 SNPs may be expressed in different cancers and diseases.…”

WNT Signaling in Cardiac and Vascular Disease

“…Similar results were obtained when bone marrow cells of sFRP1 overexpressing mice were transplanted in wild-type recipients, which subsequently were subjected to MI ( Barandon et al, 2011 ). A genetic variant of sFRP1 was reported to be associated with an increased risk of MI in a Chinese Han population ( Tao et al, 2016 ). An anti-inflammatory and antiapoptotic role for sFRP5 has also been described in a mouse model of ischemia/reperfusion damage ( Nakamura et al, 2016 ), supporting a beneficial effect of sFRPs on infarct healing.…”