Association of genetic variants of fibrinolytic system with stroke and stroke subtypes

The Role of Classic Risk Factors and Prothrombotic Factor Gene Mutations in Ischemic Stroke Risk Development in Young and Middle-Aged Individuals

“…A very similar profile of classic vascular risk factors in young ischemic stroke patients has also been reported elsewhere, however, differing in the order of frequency [3][4][5][6][7][15][16][17][18][19]. These results show that conventional vascular risk factors are significant risk factors for ischemic stroke not only in the >55 age group, but also in younger population.…”

Genetics of ischemic stroke

“…The results of our study revealed that all these genetic variants except for tPA I/D polymorphism, no other variants could be associated significantly with stroke in our study population from Andhra Pradesh. [21,22] We also found a significant association of I/D polymorphism of tPA gene with intracranial large artery atherosclerosis and stroke of undetermined etiology. Various studies have indicated that PT 20210A is uncommon in the indigenous population from north and western India.…”

What causes intracerebral bleeding after thrombolysis for acute ischaemic stroke? Recent insights into mechanisms and potential biomarkers

“…One recent meta-analysis suggested that tPA gene TPA-7351C/T polymorphism is associated with the risk of large vessel ischaemic stroke in East Asians and Caucasians,50 but this finding was not confirmed in a larger international meta-analysis 51. Another study suggested that D allele of the I/D tPA gene polymorphism might increase the risk of ischaemic stroke 52. Whether these or as yet unidentified tPA gene variants are relevant for the response to thrombolysis requires further investigation.…”