Association of Genetic Variants in the Adiponectin Gene with Metabolic Syndrome: A Case-Control Study and a Systematic Meta-Analysis in the Chinese Population

Abstract

BackgroundThe prevalence of metabolic syndrome has been rising worldwide, including in China, but knowledge on specific genetic determinants of metabolic syndrome is very limited. A number of studies have reported that polymorphisms in the ADIPOQ gene are associated with metabolic syndrome in Chinese Han populations. However, data is still conflicting. The objective of this study was to examine the associations of the adiponectin genetic variants with metabolic syndrome by a case-control study and meta-analyses in Chinese.MethodsWe first investigated the association of ADIPOQ rs2241766 (+45T>G in exon 2), rs266729 (−11377C>G in promoter) and rs1501299 (+276G>T in intron 2) polymorphisms with metabolic syndrome in a Hubei Han Chinese population with 322 metabolic syndrome patients and 161 normal controls recruited from the Yichang, Hubei. Then we comprehensively reviewed the association between ADIPOQ rs2241766/rs266729/rs1501299 and metabolic syndrome in the Chinese populations via a meta-analysis. The strength of association was assessed by odds ratios (ORs) with 95% confidence intervals (CI).ResultsThe G allele frequency of rs2241766 in metabolic syndrome patients was significantly higher than those of controls group (29.8% vs 23.3%, OR = 1.40, P = 0.033). The logistic regression analysis adjusted by gender and age showed a nominally significant association for rs2241766 GG+GT genotype (P = 0.065, OR = 1.55) and rs1501299 GG genotype in recessive model (OR = 1.54, P = 0.066). However, no association was observed for rs266729 in our sample. We identified thirteen studies for rs2241766 (2,684 metabolic syndrome patients and 2,864 controls), three studies for rs266729, and eleven studies for rs1501299 (2,889 metabolic syndrome patients and 3,304 controls) in Chinese. Meta-analysis indicated significant associations for the rs2241766 G allele (OR = 1.14, 95%CI = 1.05–1.24, P = 0.003), rs266729 GG+GT genotypes (OR = 0.80, 95%CI = 0.68–0.92, P = 0.003) and rs1501299 GG+TG genotypes (OR = 1.42, 95%CI 1.16–1.75, P = 0.001).ConclusionsOur results demonstrated ADIPOQ as a pleiotropic locus for metabolic syndrome and its components in the Han Chinese population.

Variants in <b><i>APOA5</i></b> and <b><i>ADIPOQ</i></b> Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention

“…This is intriguing, as evidence suggests that individuals homozygous for the G allele are at greater metabolic risk than T-allele carriers. For example, a recent meta-analysis of Chinese Han populations reported a greater G allele frequency in individuals with MetS [37]. Further, individuals homozygous for the GG genotype showed impaired glucose tolerance in Spanish subjects [35].…”

Adiponectin gene (ADIPOQ) polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type 2 diabetes

“…These findings suggest that +45G allele may confer a protective effect against metabolic disease and CVD in the Taiwanese population. On the other hand, in other regions of China, meta-analysis studies have reported that the G allele does not consistently show protective effects on metabolic syndrome [31], T2D [22], or CVD [32]. These contrasting results in different regions of Chinese might be explained by regional variations and different study methods including diagnostic criteria, sample size, and study design.…”

Association of the <i>ADIPOQ</i> T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

“…Nonetheless, Li et al [50] conducted a meta-analysis of Chinese Han population and found that ADIPOQ T45G may be a susceptible allele of T2D. Gao et al [51] also reported that ADIPOQ T45G is strongly associated with metabolic syndrome in Chinese Han population. FBG is an important T2D-related trait.…”