Association of genetic variants in Leptin, leptin receptor and adiponectin with hypertension risk and circulating Leptin/Adiponectin changes

Li, Yingxue; Zheng, Hongwei; Yang, Jianqi; Zhang, Boheng; Xing, Xiaowei; Zhang, Zhiyong; Zhang, Qi

doi:10.1016/j.gene.2022.147080

Cited by 2 publications

(3 citation statements)

References 51 publications

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“…Additionally, the binding of leptin to its receptor indirectly causes p70S6K to phosphorylate Ser491 on the alpha subunit of AMPK, inhibiting its effects in the hypothalamus [ 63 ]. Not surprisingly, both adiponectin and leptin are related to hypertension and blood pressure regulation as well [ 64 ]. Thus, the poor regulation of these hormones and of the AMPK pathway contribute to hyperglycemia, obesity, and hypertension, all of which are common complications associated with T2D.…”

Section: Molecular and Cellular Basis Of T2d Pathogenesismentioning

confidence: 99%

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

Chapple,

Woodfin,

Moore

2024

Molecules

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Type 2 diabetes (T2D) is a growing health concern with an estimated 462 million people having been diagnosed worldwide. T2D is characterized by chronically elevated blood glucose and insulin resistance, which culminate in a diminished function of the β-cell mass in its later stages. This can be perpetuated by and result in inflammation, excess reactive oxygen species production, obesity, and the dysregulation of multiple cellular pathways. Many naturally occurring small molecules have been investigated in terms of their roles in modulating glucose homeostasis and β-cell function. Many of these compounds can be found in commonly used sources of food and drink. Interestingly, a correlation has been observed between coffee consumption and T2D incidence. However, the specific compounds responsible for this correlation and their mechanisms are still somewhat undetermined. This paper reviews recent research findings on the effects of several polyphenols that are either found in coffee or are metabolites of compounds found in coffee (enterodiol, enterolactone, matairesinol, secoisolariciresinol, kaempferol, quercetin, and chlorogenic acid) on glucose homeostasis and health complications associated with glucose dysregulation, with a special emphasis on their potential anti-diabetic effects. The factors that affect polyphenol content in coffee are also addressed.

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Section: Molecular and Cellular Basis Of T2d Pathogenesismentioning

confidence: 99%

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

Chapple,

Woodfin,

Moore

2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Размер адипоцитов у пациентов с ожирением взаимосвязан с дисбалансом выработки адипоцитокинов в жировой ткани и смещением профиля секреции в сторону воспаления и атерогенных свой ств, сопряженных с высоким содержанием лептина [20]. Известно, что хроническая гиперлептинемия ассоциируется с повышением тонуса симпатической нервной системы, повышением уровня ренина в крови и как следствие повышением АД и частоты сердечных сокращений, гипертрофией миокарда, нарушением функции левого желудочка, увеличением частоты ишемических аритмий, дислипидемией, системным воспалением и увеличением размера инфаркта миокарда в эксперименте [21].…”

Section: оригинальные статьиunclassified

“…Установлено, что гиперлептинемия является значимым фактором риска развития атеросклероза и ИБС [20,21]. Установлено, что лептин является независимым предиктором инфаркта миокарда у мужчин и женщин с АГ [24].…”

Section: оригинальные статьиunclassified

Triple fixed-dose combination of amlodipine, indapamide and perindopril for hypertension in patients with stable coronary artery disease and abdominal obesity

Polyakova,

Khalimov

2024

Russ J Cardiol

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Aim. In an open-label clinical trial, to evaluate the effectiveness and impact on metabolic parameters of triple antihypertensive combination therapy with amlodipine, indapamide and perindopril arginine (perindopril A) in patients with hypertension (HTN) and stable coronary artery disease (CAD) in combination with abdominal obesity (AO), who have not had an adequate response to dual antihypertensive therapy for at least 4 weeks.Material and methods. The study included 68 adult patients aged 42 to 64 years (51 (47; 60) years) with AO, stable CAD and uncontrolled HTN, despite treatment with two drugs: an angiotensin-converting enzyme (ACE) inhibitor and a thiazide and thiazide-like diuretic. In the study, patients, in accordance with the general characteristics of the drug, after prescribing a free triple-dose combination of amlodipine, indapamide, perindopril in appropriate dosages, received one of the following combination of amlodipine/indapamide/perindopril for 24 weeks: group 1 (n=34) — 10/2,5/10 mg and group 2 (n=34) — 5/1,25/5 mg, one tablet daily. The analysis of the primary endpoint was to assess the change in mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the sitting position from baseline to 24 weeks. Secondary efficacy endpoints included the proportion of patients achieving target mean SBP and DBP values for this category in the sitting position of 120-130 mm Hg and 70-79 mm Hg, respectively, at 12, 16, 20 and 24 weeks. Safety was assessed throughout the study. The effect on metabolic parameters was assessed at 24 weeks of the study.Results. Sixty-seven (98,5%) patients completed the study. The mean decrease in blood pressure from the initial level (group 1159/96 mm Hg; group 2161/95 mm Hg) to 24 weeks (group 1 126/76 mm Hg; group 2 132/84 mm Hg) was significant (p<0,0001 for all). The proportion of patients who reached the target mean values of SBP (120-130 mm Hg) and DBP (70-79 mm Hg) in the sitting position by 24 weeks was 80,16% and 79,28% in group 1, respectively; in group 2 — 65,32% and 70,06%, respectively. No serious adverse events were recorded. Its administration, regardless of the doses of individual components in combination, was accompanied not only by metabolic neutrality in relation to carbohydrate, lipid and purine metabolism, a decrease in chronic inflammation, but was also associated with a decrease in serum leptin concentration and subcutaneous adipose tissue, an increase in tissue sensitivity to leptin, as well as a decrease in the size of adipocytes in subcutaneous fat.Conclusion. Triple fixed-dose of amlodipine/indapamide/perindopril in two different dosages is effective, safe and well tolerated in patients with HTN and stable CAD in combination with AO.

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Association of genetic variants in Leptin, leptin receptor and adiponectin with hypertension risk and circulating Leptin/Adiponectin changes

Cited by 2 publications

References 51 publications

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

Triple fixed-dose combination of amlodipine, indapamide and perindopril for hypertension in patients with stable coronary artery disease and abdominal obesity

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