Association of Genetic Polymorphism −670A&gt;G in the <i>Fas</i> Gene and Serum Markers AST Platelet Ratio Index, AST/ALT with Significant Fibrosis and Cirrhosis in Chronic Hepatitis C

Deghady, Akram; Abdou, Alaa; El-Neanaey, Wafaa A.; Diab, Iman

doi:10.1089/gtmb.2011.0098

Cited by 10 publications

(3 citation statements)

References 22 publications

(22 reference statements)

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“…Recently, it was found that CD95 rs1800682 A/G polymorphism was potentially associated with significant fibrosis and cirrhosis in chronic HCV patients. 23 , 38 …”

Section: Discussionmentioning

confidence: 99%

“…The purified PCR products of P53 and CD95 genes were incubated at 37 °C overnight with Bsh1236I and BstNI restriction enzymes respectively to identify three different genotypes of each gene as described in numerous previous studies [ 19 , 20 , 23 , 25 , 38 ] and illustrated in Table 1 . Restriction enzymes were purchased from (Fermentas, Ontario, Canada).…”

Section: Methodsmentioning

confidence: 99%

“… 22 CD95-670A/G (rs1800682) polymorphism was associated potentially with fibrosis and cirrhosis in patients infected with HCV. 23 In addition, authors have suggested that there was a higher frequency of CD95 rs1800682 A/A genotype in spontaneously recovered patients from HCV infection compared to patients with persistent HCV infection. 24 On the contrary, other scientists have demonstrated that there was no significant correlation between CD95 rs1800682 polymorphism and fibrotic stages, while this polymorphism may account for some of the histopathological variations in HCV infections.…”

Section: Introductionmentioning

confidence: 99%

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P53 rs1042522 and CD95 rs1800682 genetic variations in HCV-4a response to antiviral therapy

et al. 2015

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Current estimates indicate that the hepatitis C (HCV) is the leading cause of mortality around the world, with infection rates steadily increasing in Egypt. The dual therapy for this silent epidemic with pegylated-interferon-α2b/ribavirin has markedly improved the success rates in genotype-4 patients. It was reported that apoptosis plays a vital mechanistic role in limiting viral replication. P53, a key regulator of apoptosis, induces CD95 gene expression and subsequently initiates apoptotic cascade to be activated. The current study examined the impact of P53 rs1042522 and CD95 rs1800682 polymorphisms on the treatment response. Three groups of 240 volunteers were enrolled in this study; 86 in sustained virological responders group, 74 in non-responders group, and 80 in control group. All patients had HCV genotype-4a and were interferon treatment naïve. Quantizations of HCV-RNA by qRT-PCR and histological scores were performed for all patients. In addition, genotyping of HCV-RNA, P53 rs1042522 Arg/Pro and CD95 rs1800682 A/G polymorphisms were investigated in all subjects. It was resulted that P53 Pro/Pro homozygous genotype has high significant increase, while CD95 A/A homozygous genotype has high significant decrease when comparing non-responders with responders. Finally, it was concluded that Pro variant of P53 rs1042522 may be used as a genetic predictor for non-responsiveness, while A/A variant of CD95 rs1800682 may be used as a sensitive biomarker for responsiveness to antiviral therapy of HCV genotype-4a infection. In addition, low prolactin, high total testosterone, and high GH levels may provide promising biomarkers for early prediction of the response when associated with these genetic polymorphisms.

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“…Recently, it was found that CD95 rs1800682 A/G polymorphism was potentially associated with significant fibrosis and cirrhosis in chronic HCV patients. 23 , 38 …”

Section: Discussionmentioning

confidence: 99%