Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort

Bai, Dan; Yip, Benjamin Hon Kei; Windham, Gayle C.; Sourander, André; Francis, Richard W.; Yoffe, Rinat; Glasson, Emma; Mahjani, Behrang; Suominen, Auli; Leonard, Helen; Gissler, Mika; Buxbaum, Joseph D.; Wong, Kingsley; Schendel, Diana; Kodesh, Arad; Breshnahan, Michaeline; Levine, Stephen Z.; Parner, Erik Thorlund; Hansen, Stefan N.; Hultman, Christina M.; Reichenberg, Abraham; Sandin, Sven

doi:10.1001/jamapsychiatry.2019.1411

Cited by 369 publications

(301 citation statements)

References 41 publications

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“…It is now known that ASD is not a single disorder but one with many subtypes, and that it usually stems from multiple causes such as genetic and environmental factors. A growing body of evidence supports the role of genetics in ASD, and a heritability of about 80% has been reported (Bai et al, ). Both rare and common variants are associated with ASD, but the association of genetic risks derived from common risk variants with ASD traits in children from the general population remains unclear.…”

Section: Polygenic Risk Scores Were Associated With Autism‐linked Tramentioning

confidence: 99%

High Polygenic Risk Scores Associated with Autism Spectrum Disorder

2020

American J of Med Genetics Pt A

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Section: Polygenic Risk Scores Were Associated With Autism‐linked Tramentioning

confidence: 99%

High Polygenic Risk Scores Associated with Autism Spectrum Disorder

2020

American J of Med Genetics Pt A

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“…Last, most of the animal models used to study ASD are models of syndromic forms of ASD, which makes up a small proportion of ASD cases. ASD is known to have a strong genetic component (Bai et al, 2019). However that includes a variety of types of genetic variation in addition to genetically identifiable syndromes, including de novo single nucleotide and CNVs, as well as polygenic risk that results from a combination of rare and common variants (Weiner et al, 2017).…”

Section: Summary and Future D Irec Ti On Smentioning

confidence: 99%

Sleep, brain development, and autism spectrum disorders: Insights from animal models

Wintler

Schoch

Frank

et al. 2020

J of Neuroscience Research

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Sleep is an evolutionarily conserved and powerful drive, although its complete functions are still unknown. One possible function of sleep is that it promotes brain development. The amount of sleep is greatest during ages when the brain is rapidly developing, and sleep has been shown to influence critical period plasticity. This supports a role for sleep in brain development and suggests that abnormal sleep in early life may lead to abnormal development. Autism spectrum disorder (ASD) is the most prevalent neurodevelopmental disorder in the United States. It is estimated that insomnia affects 44%–86% of the ASD population, predicting the severity of ASD core symptoms and associated behavioral problems. Sleep problems impact the quality of life of both ASD individuals and their caregivers, thus it is important to understand why they are so prevalent. In this review, we explore the role of sleep in early life as a causal factor in ASD. First, we review fundamental steps in mammalian sleep ontogeny and regulation and how sleep influences brain development. Next, we summarize current knowledge gained from studying sleep in animal models of ASD. Ultimately, our goal is to highlight the importance of understanding the role of sleep in brain development and the use of animal models to provide mechanistic insight into the origin of sleep problems in ASD.

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“…The Thinking Healthy Programme for perinatal depression delivered by peer mothers in India showed significant improvement over treatment as usual (73% vs 60% remission), 3 but this was not the case in Pakistan (49% vs 45% remission). 4 Similarly, a classroom-based intervention for children in conflict settings was…”

Section: Policy Makers' Tough Choices For Psychological Interventionsmentioning

confidence: 99%

“…Articles we publish are also influential in news and social media, as indicated by Altmetric scores. The JAMA Psychiatry articles from 2019 with the highest Altmetric score are listed in the Table. 2- 4 One of these articles also made it onto the list of top 100 scientific articles with the highest Altmetric scores for 2019. 6 JAMA Psychiatry has a deserved reputation for publishing rigorous and sophisticated scientific research, but it also caters to a broad clinical audience.…”

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confidence: 99%

JAMA Psychiatry—The Year in Review, 2019

Öngür

2020

JAMA Psychiatry

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JAMA Psychiatry experienced both stability and evolution in 2019. We celebrated the 100th anniversary of the Archives of Neurology and Psychiatry, which I discussed recently. 1 In important ways, the history of our journal mirrors the history of American psychiatry: we benefit from the traditions developed over 100 years but must face the ongoing challenge of alleviating the heavy and rising burden of psychiatric disorders.Our editorial team remains in place with Martin Paulus, MD, serving as Deputy Editor, H. Blair Simpson, MD, PhD, as Associate Editor, and John Torous, MD, MS, as Web Editor. Sara DiBari remains the journal's Editorial Manager and most critical support. To this team, we have added an expanded group of Statistical Editors who regularly review articles for the journal and provide editorial input. Psychiatric science is broad and diverse, and no one biostatistician can have expertise in all the domains we cover, from clinical trials to epidemiology and neuroimaging. Therefore, we rely on a group of individuals with complementary expertise within biostatistics to help us evaluate as many of the articles we ultimately publish as possible. I am thankful for their contributions.The journal continues to receive ever-growing numbers of submissions, with the number of manuscripts received in 2019 surpassing the previous all-time high mark (Table ). [2][3][4] We make it a priority to handle all manuscripts in a timely and responsive manner despite this larger volume. Those manuscripts we decide not to pursue, we reject with a median turnaround time of 2 days so that authors can submit their work elsewhere in quick succession. We only send a small percentage of manuscripts out for peer review, and in 2019, we ultimately published 8% of all submitted research manuscripts. We also strive to maintain a fast pace for manuscripts sent out for peer review; last year it took 32 days from receipt to first decision for those articles. This allows us to make timely editorial decisions and rapidly publish accepted manuscripts. I am proud of our team for maintaining these high standards, all of which serve to improve the experience of our authors who submit their best work to JAMA Psychiatry.Every day, I am humbled by the hard work, expertise, intelligence, and collegiality of experts across the globe who review manuscripts for the journal. It inspires me to do just as good a job as editor, which is what our reviewers deserve. Peer review is laborious and complex, but even in this preprint server era, I am confident that it greatly improves the quality of the articles we publish. I thank all our peer reviewers for their contribution. 5 JAMA Psychiatry remains a leading journal in our field. In 2019, our impact factor was 15.9. We have more than 54 000 followers on Twitter and Facebook and more than 64 000 individual recipients of our weekly electronic table of contents. In 2019, we had more than 5.2 million full-text/PDF articles downloaded from our website. Articles we publish are also influential in news and socia...

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Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort

Cited by 369 publications

References 41 publications

High Polygenic Risk Scores Associated with Autism Spectrum Disorder

High Polygenic Risk Scores Associated with Autism Spectrum Disorder

Sleep, brain development, and autism spectrum disorders: Insights from animal models

JAMA Psychiatry—The Year in Review, 2019

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