Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses

Abstract

ObjectiveOne of the important proteins involved in lipid metabolism is the ATP-binding cassette transporter A1 (ABCA1) encoding by ABCA1 gene. In this study we evaluated the single nucleotide polymorphisms (SNPs) of ABCA1 gene. We analyzed SNPs in chromosome 9 such as rs2230806 (R219K) in the position 107620867, rs2230808 (R1587K) in the position 106602625 and rs4149313 (I883M) in the position 106626574 according to gender and lipid profile of Greek nurses.MethodsThe study population consisted of 447 (87 men) unrelated nurses who were genotyped for ABCA1 gene polymorphisms. Additionally, lipid profile [total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C) and apolipoprotein A1] was evaluated.ResultsThe distribution of all three studied ABCA1 gene polymorphisms did not differ according to gender. However, only R219K genotype distribution bared borderline statistical significance (p = 0.08) between the two studied groups. Moreover, allele frequencies of R219K, R1587K and I88M polymorphisms did not differ according to gender. In general, blood lipid levels did not seem to vary according to ABCA1 gene polymorphisms, when testing all subjects or when testing only men or only women. However, a significant difference of LDL-C distribution was detected in all subjects according to R1587K genotype, indicating lower LDL-C levels with KK polymorphism (p = 0.0025). The above difference was solely detected on female population (p = 0.0053).ConclusionsThe ABCA1 gene polymorphisms frequency, distribution and lipid profile did not differ according to gender. However, in the female population the KK genotype of R1587K gene indicated lower LDL-C levels. Further studies, involving a higher number of individuals, are required to clarify genes and gender contribution.

Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern

“…But no difference was observed in the level of TC. These results were similar to those of previous reports [17,18]. …”

Effect of ATP-binding Cassette Transporter A1 (ABCA1) Gene Polymorphisms on Plasma Lipid Variables and Common Demographic Parameters in Greek Nurses

“…In analyses based on ethnicity, the association was still significant in Asians, but not in Caucasians. According to our previous [11] study from the young Greek women-nurses (living and working in the similar conditions) we did not find any association of R219K with demographic (smoking, waist circumference, BMI) or lipid parameters. Similarly in this study we have not observed any association of R219K gene polymorphism and demographic and lipid parameters.…”

<i>ATP-binding cassette transporter A1</i> (<i>ABCA1</i>) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population: cross-sectional data from the Daiko Study

“…In the present study, the mean HDL-C level was 1.6 mg/dL higher in KK genotype than in RR in men, and 1.0 mg/dL higher in KK than in RR in women. The mean difference between KK and RR genotypes varied from -0.4 to 19.0 mg/dL in Asian populations and from -15 to 3.1 mg/dL in Western populations [16,17]. In other representitive studies in Asians, the differences were 2.32 and 1.16 mg/dL in Li et al [18], 1.16 and 1.55 mg/dL in Li et al [19], and 4.65 and 1.55 mg/dL by Zhao and Xiao, respectively [20], while 0.77 and 0.39 mg/dL in Porchay-Balderelli et al in Caucasians [21].…”