“…Of the six studies [4,5,6,7,8,9], only in two studies did participants routinely undergo EGD [7,9]. Furthermore, prior studies were limited by small sample sizes, cross-sectional design, and lack of information on potential confounders [4,5,7,8,9]. Four of the six studies did not adjust for Helicobacter pylori status and/or the regular use of either NSAIDs or antiplatelet, which are well-recognized causes of PUD [4,7,8,9].…”