Association of gamma-tocopherol serum concentrations and blood pressure among adults in the United States: a cross-sectional study

Abstract

Backgroundhypertension is one of the major preventable risk factors for numerous diseases. The role of vitamin E in blood pressure (BP) has been controversial. We aimed to investigate the relationship between gamma-tocopherol serum concentration (GTSC) and BPMethodsData from 15,687 US adults from the National Health and Nutrition Examination Survey (NHANES) were analyzed. The correlations of GTSC with systolic BP (SBP), diastolic BP (DBP), and prevalence of hypertension were investigated by multivariate logistic regression models, generalized summation models, and fitted smoothing curves. Subgroup analyses were performed to investigate possible effect modifiers between them.ResultsWith each natural log increase in GTSC, SBP, and DBP increased by 1.28 mmHg (β 1.28, 95% CI 0.71–1.84) and 1.15 mmHg (β 1.15, 95% CI 0.72–1.57), respectively, both P for trend < 0.001; the prevalence of hypertension increased by 12% (OR 1.12, 95% CI 1.03–1.22), P for trend 0.008. In subgroup analysis, in drinkers, with each natural log increase in GTSC, SBP, and DBP increased by 1.77 mmHg (β 1.77,95% CI 1.13–2.41) and 1.37 mmHg (β 1.37,95% CI 0.9–1.85), respectively, whereas they were not correlated in non-drinkers.ConclusionGTSC was linearly and positively associated with SBP, DBP, and the prevalence of hypertension, and alcohol consumption may modify the relationship of GTSC with SBP and DBP.

Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

“…The higher the concentration of GTSC, the higher the prevalence of hypertension and blood pressure. 46 This is similar to the results of Zhang et al 42 who found that when dietary vitamin E intake was greater than 40.53 mg/day, the risk of new hypertension was higher. The specific mechanism needs further study.…”