Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients

Ali, Samir Ben; Kallel, Amani; Ftouhi, B.; Sediri, Yousra; Feki, Moncef; Slimane, H.; Jemaa, Riadh; Kaabachi, Naziha

doi:10.1016/j.clinbiochem.2008.11.001

Cited by 51 publications

(24 citation statements)

References 26 publications

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“…Tel/Fax: +34-91-5432880; E-mail: cgarces@fjd.es levels (Mammès et al, 1998;Li et al, 1999). This polymorphism has also been linked to obesity (Li et al, 1999;Mammès et al, 2000;Ben Ali et al, 2009) and body mass index (BMI) (Jiang et al, 2004), although some studies have failed to find these associations (Portolés et al, 2006;Duarte et al, 2007). Studies in children are scarce, and, to our knowledge, the association between the LEP G-2548A polymorphism and leptin levels has been analysed only in obese girls (Le Stunff et al, 2000).…”

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confidence: 99%

Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents^‡

Riestra

García-Anguita

Viturro

et al. 2010

Annals of Human Genetics

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SummaryPolymorphisms in the leptin gene (LEP) have been associated with leptin levels and obesity in some studies in adults though this link has scarcely been investigated in children. In our study, we examined the relationship of the LEP G-2548A polymorphism with leptin levels, anthropometric variables and body composition in a population-based sample of pubescent children. Our study included 880 healthy schoolchildren (419 males and 461 females), 12-16 years of age. Plasma leptin levels were determined by ELISA. The LEP polymorphism was determined by allelic discrimination TaqMan R assay. Male carriers of the AA genotype had significantly lower plasma leptin levels than GA (p < 0.008) and GG (p < 0.001) carriers and significantly lower mean hip circumference (HC) values than GG carriers (p = 0.04). In girls, leptin levels were also lower in A-allele carriers than in GG carriers, and BMI and HC were significantly lower in AA carriers as compared with GG carriers. In addition, the frequency of the A allele was significantly lower (χ 2 : 4.58, p = 0.032) in the OW-obese than in the NW group. In conclusion, the LEP G-2548A polymorphism is associated with variations in leptin levels, BMI and HC in Spanish pubertal children, and evidence suggests a link between the G allele and presence of overweight in girls.

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Section: Introductionmentioning

confidence: 99%

Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents^‡

Riestra

García-Anguita

Viturro

et al. 2010

Annals of Human Genetics

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“…However, the direct association between the -2548 G/A polymorphism and obesity remains vague. While most current published studies have failed to identify a significant association in various populations [18,19,20,21,22,23,24], 3 studies found that the current variant was significantly associated with the risk of obesity (defined as BMI ≥30) in subjects of mixed race (South America) [25] and Caucasians (Turkish and Tunisian) [26,27]. Additionally, while most pieces of evidence have indicated that the frequency of the GG genotype or G allele is higher in the obesity or overweight group compared to that of the control in various populations [16,25,28], Nieters et al [29] found a sharply contrasting outcome, i.e.…”

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confidence: 99%

Association of Leptin Gene -2548 G/A Polymorphism with Obesity: A Meta-Analysis

Yuan

Xiao

et al. 2014

Ann Nutr Metab

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Background: A common single-nucleotide polymorphism identified in the 5′-untranslated region of the leptin gene (LEP -2548 G/A polymorphism) may be associated with obesity, but the existing research findings are inconsistent, so we conducted this meta-analysis. Methods: Medline, Embase and ISI Web of Science databases were searched to identify relevant studies. Meta-analysis of the total and subgroup populations was conducted using allelic, additive, dominant and recessive models, and odds ratios and their 95% confidence intervals were calculated in a fixed-effect model if no heterogeneity (evaluated as I² statistic) existed. Otherwise, a random-effects model was adopted. Subgroup analysis was performed by ethnicity. Meta-regression and the HETRED analysis were used to explore the potential sources of between-study heterogeneity. Egger's test and influence analysis were conducted to evaluate the publication bias and study power, respectively. Results: The final selection enrolled 9 studies, including 2,988 subjects (1,372 obese subjects and 1,616 controls). No significant association was identified between the LEP -2548 G/A polymorphism and obesity for all genetic models in the overall population and Caucasians. We found a significant association with allelic, additive and dominant models for subjects of mixed race from South America. Notwithstanding, this significance should be treated cautiously for it is based on a rather small sample (788 involved subjects). Conclusions: In total, the combined analysis of data from current and published studies suggested that the LEP -2548 G/A polymorphism does not contribute to the development of obesity, despite the fact that a significant association exists in a small subgroup from South America. Further studies are needed to elucidate the relationship.

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“…The consistency of this idea resulted in several studies reporting an association of SNPs at 5' regulatory region (rs7799039 and rs2167270) with leptin levels and obesity. 9,11,13,18,31 Previous studies have shown both increased 10,32 and decreased 13 levels of circulating leptin in subjects carrying the AA genotype of the leptin gene promoter rs7799039 polymorphism. We found increased levels of leptin only in the homozygous state of A allele.…”

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“…10 Contrastingly, some of the studies showed a lack of association. [11][12][13] The discrepancies between the studies may be due to different ethnicity, characteristics of subjects or consideration of varied covariate for adjustment during analysis.…”

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confidence: 99%

“…However, there are studies that failed to demonstrate this association. [11][12][13] To address these discordant observations, along with the necessity to conduct additional analyses particularly in countries with diverse populations like India, we proposed to investigate the possible influence of the different variants of leptin gene on obesity traits and leptin levels in a South Indian population.…”

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Genetic variants in leptin: Determinants of obesity and leptin levels in South Indian population

et al. 2014

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Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients

Cited by 51 publications

References 26 publications

Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents^‡

Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents^‡

Association of Leptin Gene -2548 G/A Polymorphism with Obesity: A Meta-Analysis

Genetic variants in leptin: Determinants of obesity and leptin levels in South Indian population

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Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients

Cited by 51 publications

References 26 publications

Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents‡

Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents‡

Association of Leptin Gene -2548 G/A Polymorphism with Obesity: A Meta-Analysis

Genetic variants in leptin: Determinants of obesity and leptin levels in South Indian population

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Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents^‡

Influence of the leptin G‐2548A polymorphism on leptin levels and anthropometric measurements in healthy Spanish adolescents^‡