2022
DOI: 10.1016/j.rgmxen.2021.07.001
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Association of Fusobacterium nucleatum infection and colorectal cancer: A Mexican study

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Cited by 9 publications
(7 citation statements)
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“…Moreover, the RPA-CRISPR-Cas12a-Fn assay had lower requirements for personnel, environment, and equipment, allowing for rapid sample testing and identification under specific conditions. In contrast, qPCR requires a more stringent operating environment, complex detection equipment, and higher demands on laboratory personnel, resulting in a longer overall testing time ( 31 , 32 ). Therefore, the RPA-CRISPR-Cas12a-Fn assay has significant advantages over qPCR.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the RPA-CRISPR-Cas12a-Fn assay had lower requirements for personnel, environment, and equipment, allowing for rapid sample testing and identification under specific conditions. In contrast, qPCR requires a more stringent operating environment, complex detection equipment, and higher demands on laboratory personnel, resulting in a longer overall testing time ( 31 , 32 ). Therefore, the RPA-CRISPR-Cas12a-Fn assay has significant advantages over qPCR.…”
Section: Discussionmentioning
confidence: 99%
“…The used GAPDH forward primer is 5′-GTCTCCTCTGACTTCAACAGCG -3′ and reverse primer is 5′-ACCACCCTGTTGCTGTAGCCAA -3′. 17 Real time PCR was done using Applied Biosystems Ste-pOne Real-time PCR System. (Cat.…”
Section: Methodsmentioning
confidence: 99%
“…Fusobacterium nucleatum is highly enriched in tumor tissue samples from patients diagnosed with CRC. CRC is associated with the disruption of the colonic architecture with increased immune cell infiltration and depleted mucus layers [ 73 , 74 ]. Lactic acid bacteria (LAB) strains potently activate intracellular sensors, including stimulator of IFN genes (STING) and mitochondrial antiviral signaling (MAVS) that result in type I IFN (IFN-I) production, cytoprotective responses, and prevention of overreactive NF-κB-dependent inflammation in the gut [ 75 ].…”
Section: Cancer—microbiome—immune Axismentioning
confidence: 99%