Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China

Li, Yan; Sun, Donglin; Duan, Yanan; Zhang, Xiaojuan; Wang, Na; Zhou, Rong‐Miao; Chen, Zhifeng; Wang, Shijie

doi:10.1007/s11033-009-9593-4

Cited by 60 publications

(39 citation statements)

References 22 publications

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“…Fruh et al [56] found the presence of CC allele at MMP-2 -1306 position in H. pylori infected individuals which provide protection against esophagus adenocarcinoma. Studies also reported that presence of CC allele at -1306 site increases the risk of ESCC, although Chen et al [54,57] did not observe any positive association of MMP-2 -1306 C/T polymorphism with ESCC in Mongolian population suggests differences in genetic susceptibility between Han-ethnic Chinese and the Mongolian population. However, both positive and negative influences of MMP-2 -1306 C/T polymorphism with gastric cancer in Asian and Caucasian population were reported [58] .…”

Section: Mmps Polymorphism In Tumor Formationmentioning

confidence: 96%

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Verma

Kesh

Ganguly

et al. 2014

WJBC

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teinase (TIMP) which bind MMPs with a 1:1 stoichiometry. In addition, RECK (reversion including cysteinerich protein with kazal motifs) is a membrane bound glycoprotein that inhibits MMP-2, -9 and -14. Moreover, α2-macroglobulin mediates the uptake of several MMPs thereby inhibit their activity. Cancerous conditions increase intrinsic reactive oxygen species (ROS) through mitochondrial dysfunction leading to altered protease/ anti-protease balance. ROS, an index of oxidative stress is also involved in tumorigenesis by activation of different MAP kinase pathways including MMP induction. Oxidative stress is involved in cancer by changing the activity and expression of regulatory proteins especially MMPs. Epidemiological studies have shown that high intake of fruits that rich in antioxidants is associated with a lower cancer incidence. Evidence indicates that some antioxidants inhibit the growth of malignant cells by inducing apoptosis and inhibiting the activity of MMPs. This review is discussed in six subchapters, as follows. AbstractThe process of carcinogenesis is tightly regulated by antioxidant enzymes and matrix degrading enzymes, namely, matrix metalloproteinases (MMPs). Degradation of extracellular matrix (ECM) proteins like collagen, proteoglycan, laminin, elastin and fibronectin is considered to be the prerequisite for tumor invasion and metastasis. MMPs can degrade essentially all of the ECM components and, most MMPs also substantially contribute to angiogenesis, differentiation, proliferation and apoptosis. Hence, MMPs are important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. The implications of MMPs in cancers are no longer mysterious; however, the mechanism of action is yet to be explained. Herein, our major interest is to clarify how MMPs are tied up with gastrointestinal cancers. Gastrointestinal cancer is a variety of cancer types, including the cancers of gastrointestinal tract and organs, i.e., esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The activity of MMPs is regulated by its endogenous inhibitor tissue inhibitor of metallopro-

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Section: Mmps Polymorphism In Tumor Formationmentioning

confidence: 96%

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Verma

Kesh

Ganguly

et al. 2014

WJBC

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“…The genotype variants were analyzed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) methodology for all the SNPs. Primer sequences, PCR conditions and the restriction enzymes used have been described elsewhere for both MMP2 and TIMP2 [12][13][14][15]. Positive and negative controls were used in each genotyping assay, and 5 % of the samples were randomly selected and run in duplicates with 100 % concordance.…”

Section: Mmp-2 (-735c [ T) [Rs 2285053] and Timp-2 (-418g [ C) [Rs 81mentioning

confidence: 99%

No Association of Matrix Metalloproteinase [MMP]-2 (−735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (−418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility

et al. 2012

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Genomic DNA extraction from peripheral blood samples, collected from the study subjects, was carried out using salting-out method. MMP-2 and TIMP-2 genotyping was performed using polymerase chain reaction-based restriction fragment length polymorphism. Our findings demonstrated no significant association between MMP-2 (-735C [ T) and TIMP-2 (-418G [ C) gene polymorphisms and the risk of developing cervical cancer in the study population. Further stratified analysis using a caseonly study approach revealed that there was no effect of MMP-2/TIMP-2 polymorphisms on early and advanced stages of cervical cancer. Further MMP-2 and TIMP-2 polymorphisms did not modulate the risk in cervical cancer patients who smoked tobacco/cigarettes. Overall, the present study demonstrated a lack of association between MMP-2 and TIMP-2 gene polymorphisms and cervical cancer susceptibility in women of Northern India.

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“…40 Furthermore, polymorphisms in MMP2 in nonsmokers, and MMP12 and MMP13 in smokers, have been linked to gastric cardia adenocarcinoma in a high-incidence region of north China. 41 In a large meta-analysis, Peng et al found that MMP2 (-1306C>T and -735C>T) and MMP7 -181A>G polymorphisms play allele-specific roles in cancer development, while the MMP9 -1562C>T polymorphism did not appear to be a major risk factor for cancer. 42 Another meta-analysis by Li et al, 43 focusing on digestive tract cancers, demonstrated an association of polymorphisms in the promoter regions of specific MMPs with increased (MMP1 and -7) or decreased (MMP2 and -9) susceptibility, while Yang et al 44 further suggested that the MMP7 -181A>G polymorphism may contribute to susceptibility to gastric cancer.…”

mentioning

confidence: 99%

Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24 distinct genes. Their functions have been implicated in numerous normal and pathologic processes, including uterine involution and organogenesis, inflammation and wound healing, vascular and autoimmune disease progression. Pertinent to this review, the role of MMPs in cancer biology is fairly well researched and documented, and remains a subject of continuing intense investigation. Not only are several MMPs overexpressed in head and neck squamous cell carcinomas (HNSCCs), expression has been correlated with salient tumorigenic hallmarks, such as cell proliferation, angiogenesis, invasion, and metastasis. The utility of changes in the expression profile, as well as various MMP polymorphisms as potential prognostic markers in oral cancers and oral premalignant lesions, have been investigated. Furthermore, the potential therapeutic utility of targeting MMPs in cancer remains attractive, although outcomes in this respect appear so far to be less encouraging with respect to HNSCCs. Because of the disappointing results observed in clinical trials where MMP-targeting regimens for HNSCCs utilized broad-spectrum small MMP catalytic site inhibitors, investigators now envision new strategies for MMP-specific targeting based on the recognition of new noncatalytic MMP domains with distinct functions. This review provides an overview of MMP activities in general and in cancers, and an update of their activities in HNSCC. Specifically, their role in the development and progression of HNSCC and their function as signaling molecules is discussed. Finally, their role as potential prognostic biomarkers and therapeutic targets in HNSCC is revisited.

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Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China

Cited by 60 publications

References 22 publications

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

No Association of Matrix Metalloproteinase [MMP]-2 (−735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (−418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility

Matrix metalloproteinases in head and neck cancer: current perspectives

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