Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome

Wehr, Elisabeth; Schweighofer, Natascha; Möller, Reinhard; Giuliani, Albrecht; Pieber, Thomas R.; Obermayer–Pietsch, Barbara

doi:10.1016/j.metabol.2009.08.023

Cited by 71 publications

(80 citation statements)

References 29 publications

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“…Those women differ from women without a positive FHx of T2DM, which might be related to either genetic or environmental factors. Of note, it has been shown that T2DM-related genetic variants are also associated with PCOS phenotype and risk (3,15). To our knowledge, it has not been investigated so far whether PCOS women with a positive FHx of T2DM have a higher prevalence of T2DM-related genetic variants than PCOS women with a negative T2DM FHx.…”

Section: European Journal Of Endocrinologymentioning

confidence: 97%

“…Further, there is evidence showing that a positive family history (FHx) of T2DM, as a reflection of genetic risk, is associated with an increased risk of the development of T2DM in PCOS women (12,13,14). In PCOS women, obesity and T2DM-related genes (3,15) as well as genetic polymorphisms related to hyperandrogenism (16) have been shown to be associated with PCOS phenotype, suggesting an important genetic background. Apart from this, it has not been investigated so far whether a positive FHx of T2DM and PCOS contribute equally to metabolic and endocrine disturbances in PCOS women or whether there are differences regarding the impact of T2DM and PCOS FHx on metabolic and endocrine parameters.…”

Section: Introductionmentioning

confidence: 99%

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Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women

Lerchbaum

Schwetz

Obermayer-Pietsch

2014

European Journal of Endocrinology

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Objective: There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We aim to study the metabolic and endocrine characteristics of PCOS women with and without a family history (FHx) of type 2 diabetes mellitus (T2DM) and PCOS. Design: Cross-sectional study. Methods: We analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine parameters in 714 PCOS women. Results: A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectively. We found an independent association of T2DM FHx with central fat accumulation, obesity, prediabetes, metabolic syndrome (MS), insulin resistance, low HDL and elevated blood pressure (P!0.05 for all). PCOS FHx was independently associated with prediabetes (P!0.05). We observed an independent association of PCOS FHx with clinical and biochemical hyperandrogenism (P!0.05 for all), whereas there was no independent association of T2DM FHx with hyperandrogenism. PCOS women with a positive FHx of both T2DM and PCOS had an adverse metabolic and endocrine profile including a linear increase in risk of obesity, central fat accumulation, MS, prediabetes and low HDL (P!0.05 for all). Conclusions: Our findings suggest that the assessment of FHx might allow risk stratification of PCOS women, which is important considering the high prevalence of PCOS.

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Section: European Journal Of Endocrinologymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women

Lerchbaum

Schwetz

Obermayer-Pietsch

2014

European Journal of Endocrinology

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“…26,30 Obese PCOS women have more severe hyperandrogenism and related clinical features such as hirsutism, irregular menstrual cycle and anovulation than non-obese PCOS women. A further clinical and endocrinological improvement in obese women with PCOS can be reversed by weight loss.…”

Section: Resultsmentioning

confidence: 99%

“…[17][18][19] In recent, researchers identified heterogeneous associations between T2D susceptibility genes and risk of PCOS in multiple ethnic populations [20][21][22][23] but also demonstrated that its effect was likely through BMI. [24][25][26][27] Given the phenotypic and environmental correlations between PCOS and obesity, it is important to investigate a possible pleiotropic effect for genetic contributions of PCOS through obesity-related conditions. In this study, we therefore hypothesized that genetic variants predisposing to risk of PCOS may contribute to risk of obesity.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition

Hwang

Lee

et al. 2012

J Hum Genet

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To investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n ¼ 1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the well-known risk factors for PCOS. Genome-wide association study. Women with or without PCOS. A total of 1881 samples were genotyped using Illumina HumanOmni1 Quad v1 and processed by R packages. The PCOS patients were divided into two subgroups according to PCOS diagnostic criteria (Rotterdam and National Institutes of Health (NIH)). For PCOS-associated loci in the two definitions, we successfully confirmed significant associations of GYS2 for body mass index in the discovery stage. We further replicated pleiotropic associations of GYS2 in a childhood obesity study (n ¼ 482) and in a gestational diabetes study (n ¼ 1710), respectively. Our study provides a preliminary framework upon diverse genetic effects underlying PCOS in Korean women. A newly identified GYS2 gene as a predisposing factor of PCOS might expand understanding of the biological pathways in metabolic and endocrine regulation.

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“…Genome-wide association study identified the fat mass and obesity-associated (FTO) gene as an obesity susceptibility gene (Frayling et al, 2007). The human FTO gene is located on chromosome 16 and expressed in a wide range of tissues, including the adipose tissue and specific areas of the brain and muscles, suggesting its potential role in body weight regulation (Wehr et al, 2010). Several single nucleotide polymorphisms (SNP) of the FTO gene have been described.…”

Section: Introductionmentioning

confidence: 99%

Association between Fat Mass and Obesity Associated (FTO) Gene Polymorphism (rs9939609) and Polycystic Ovary Syndrome (PCOS): A Sri Lankan Study

2018

Dec. 14-15, 2017 Kuala Lumpur (Malaysia)

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Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome

Cited by 71 publications

References 29 publications

Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women

Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women

Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition

Association between Fat Mass and Obesity Associated (FTO) Gene Polymorphism (rs9939609) and Polycystic Ovary Syndrome (PCOS): A Sri Lankan Study

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