2013
DOI: 10.1016/j.arr.2012.03.001
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Association of frailty with survival: A systematic literature review

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Cited by 514 publications
(461 citation statements)
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References 110 publications
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“…This decreased renal function is associated with increased all cause and cardiovascular mortality even in people over 75 years of age 3 . Although impaired physical function appears to be a risk marker for mortality in younger CKD patients 4 , it is less clear in older patients whether decreased renal function and impaired physical function are independent risk markers for mortality, or whether low glomerular filtration rate merely reflects frailty or impaired physical functionthemselves both powerful markers for mortality in older people 5 . Clarifying this issue is important, firstly in deciding whether labelling very old patients as having CKD serves a useful purpose, and secondly in considering whether intervening to ameliorate declines in renal function in the oldest old are likely to translate into clinically relevant benefits.…”
Section: Introductionmentioning
confidence: 99%
“…This decreased renal function is associated with increased all cause and cardiovascular mortality even in people over 75 years of age 3 . Although impaired physical function appears to be a risk marker for mortality in younger CKD patients 4 , it is less clear in older patients whether decreased renal function and impaired physical function are independent risk markers for mortality, or whether low glomerular filtration rate merely reflects frailty or impaired physical functionthemselves both powerful markers for mortality in older people 5 . Clarifying this issue is important, firstly in deciding whether labelling very old patients as having CKD serves a useful purpose, and secondly in considering whether intervening to ameliorate declines in renal function in the oldest old are likely to translate into clinically relevant benefits.…”
Section: Introductionmentioning
confidence: 99%
“…One systematic review reported hazard ratios linking frailty and mortality, but did not determine whether frailty was more lethal for males or for females (Shamliyan et al, 2013). Furthermore, the majority of studies included in these reviews represented populations from North America, with only small contributions from Europe and Asia.…”
Section: Accepted M Manuscriptmentioning
confidence: 99%
“…Systematic reviews have found the prevalence of frailty to be higher in older females than males, using phenotypic and cumulative deficit models of frailty (Collard et al, 2012;Shamliyan et al, 2013).…”
Section: Accepted M Manuscriptmentioning
confidence: 99%
“…The older adult population is growing, and frailty is associated with increased risk of disability, hospitalization, and mortality. 14 Frail individuals are more susceptible to adverse outcomes, including adverse drug effects such as delirium and falls. These risks may be aggravated by inappropriate use and dosing of individual drugs as well as polypharmacy, a common issue in frail individuals.…”
mentioning
confidence: 99%