Association of Frailty With Nutritional Status in Patients With Chronic Kidney Disease

Tseng, Pei Wei; Lin, Ting-Yun; Hung, Szu-Chun

doi:10.1053/j.jrn.2023.09.003

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Contrary to the findings of Tseng PW et al [20], who reported a positive and significant association between low protein intake and the development of frailty, we did not observe such an association in our cohort. This is consistent with a systemic meta-analysis conducted in the general population, which yielded conflicting results regarding the overall amount of protein intake and frailty development [21].…”

Section: Discussioncontrasting

confidence: 99%

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Chan,

Ng,

Cheng

et al. 2023

Nutrients

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Background: The relationship between dietary patterns and the malnutrition–inflammation–frailty complex in patients undergoing peritoneal dialysis (PD) is currently unknown. Our objective was to measure dietary nutrient intake and evaluate its association with malnutrition, inflammation, and frailty. Methods: We prospectively recruited adult PD patients. We assessed their dietary nutrient intake using a food frequency questionnaire. Frailty, malnutrition, and inflammation were evaluated by validated Frailty Score (FQ), Subjective Global Assessment (SGA), and Malnutrition-Inflammation Score (MIS). Results: A total of 209 patients were recruited for the study. Among them, 89 patients (42.6%) had an insufficient protein intake, and 104 patients (49.8%) had an insufficient energy intake. Additionally, 127 subjects were identified as frail, characterized by being older (61.9 ± 9.5 vs. 55.6 ± 12.8, p < 0.001), malnourished (SGA: 21.0 ± 2.7 vs. 22.7 ± 3.1, p < 0.001), and having a high inflammation burden (MIS: 10.55 ± 3.72 vs. 7.18 ± 3.61, p < 0.001). There was a significant correlation between dietary zinc intake and body mass index (r = 0.31, p < 0.001), SGA (r = 0.22, p = 0.01), and MIS (r = −0.22, p = 0.01). In the multivariate model, a higher dietary zinc intake predicted a higher SGA (beta 0.03, p = 0.003) and lower FQ (beta −0.38, p < 0.001) and MIS (beta −0.14, p < 0.001), indicating a better nutrition, less frail and inflamed state. A higher dietary zinc intake was also associated with a lower odds of being frail (adjusted odds ratio 0.96, p = 0.009). Conclusion: Dietary inadequacy and micronutrient deficiency are common among the PD population. Dietary zinc intake is independently associated with an improved nutrition, physical condition, and reduced inflammatory state.

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Section: Discussioncontrasting

confidence: 99%

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Chan,

Ng,

Cheng

et al. 2023

Nutrients

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“…Additionally, it presents various neurological complications, including anxiety, sleep disturbances, motor abnormalities, depression, and cognitive impairment [ 7 ]. Due to their chronic inflammatory state, CKD patients often experience protein-energy wasting, leading to frequent malnutrition [ 8 ]. CKD also induces a complex pattern of mineral disturbances and bone disorders associated with abnormal vascular calcification and endocrine dysregulation [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview

Izzo,

Secondulfo,

Bilancio

et al. 2024

Life

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Chronic kidney disease (CKD) is a global health issue with a rising prevalence, affecting 697.5 million people worldwide. It imposes a substantial burden, contributing to 35.8 million disability-adjusted life years (DALYs) and 1.2 million deaths in 2017. The mortality rate for CKD has increased by 41.5% between 1990 and 2017, positioning it as a significant cause of global mortality. CKD is associated with diverse health complications, impacting cardiovascular, neurological, nutritional, and endocrine aspects. One prominent complication is CKD–mineral and bone disorder (MBD), a complex condition involving dysregulation of bone turnover, mineralization, and strength, accompanied by soft tissue and vascular calcification. Alterations in mineral metabolism, including calcium, phosphate, parathyroid hormone (PTH), vitamin D, fibroblast growth factor-23 (FGF-23), and Klotho, play pivotal roles in CKD-MBD. These disturbances, observed early in CKD, contribute to the progression of bone disorders and renal osteodystrophy (ROD). Vascular calcification (VC) is a key component of CKD-MBD, accelerated by CKD. The pathophysiology involves complex processes in vascular smooth muscle cells and the formation of calciprotein particles (CPP). VC is closely linked to cardiovascular events and mortality, emphasizing its prognostic significance. Various serum markers and imaging techniques, including lateral plain X-ray, Kauppila Score, Adragao Score, and pulse wave velocity, aid in VC detection. Additionally, pQCT provides valuable information on arterial calcifications, offering an advantage over traditional scoring systems. CKD poses a substantial global health burden, and its complications, including CKD-MBD and VC, significantly contribute to morbidity and mortality. Understanding the intricate relationships between mineral metabolism, bone disorders, and vascular calcification is crucial for effective diagnosis and therapeutic interventions.

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Dietitians Play a Crucial and Expanding Role in Renal Nutrition and Medical Nutrition Therapy

Kistler,

Avesani,

Burrowes

et al. 2024

Journal of Renal Nutrition

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Association of Frailty With Nutritional Status in Patients With Chronic Kidney Disease

Cited by 5 publications

References 30 publications

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Dietary Micronutrient Intake and Its Relationship with the Malnutrition–Inflammation–Frailty Complex in Patients Undergoing Peritoneal Dialysis

Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview

Dietitians Play a Crucial and Expanding Role in Renal Nutrition and Medical Nutrition Therapy

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