Association of FLAIR vascular hyperintensity and acute MCA stroke outcome changes with the severity of leukoaraiosis

Shang, Wenjin; Shu, Liming; Zhou, Xianju; Liao, Huanquan; Chen, X. H.; Hong, Ha-Cheol; Chen, H. B.

doi:10.1007/s10072-020-04411-8

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…However, the association between chronic microvascular disease state and leptomeningeal collaterals is controversial. [7][8][9][10][11] Indeed, several methodological aspects of these studies deserve careful consideration. In fact, collateral circulation and WMH burden assessment varied widely between studies making comparison difficult.…”

Section: Clinical and Population Sciencesmentioning

confidence: 99%

“…7 However, data about the influence of WMH burden on leptomeningeal collaterals recruitment have been conflicting. [7][8][9][10][11] We aimed to determine whether the WMH burden on pretreatment neuroimaging is associated with collateral development in patients treated by endovascular…”

mentioning

confidence: 99%

“…7 However, data about the influence of WMH burden on leptomeningeal collaterals recruitment have been conflicting. 7–11…”

mentioning

confidence: 99%

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White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke

Derraz

Abdelrady

Gaillard

et al. 2021

Stroke

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Background and Purpose: White matter hyperintensity (WMH), a marker of chronic cerebral small vessel disease, might impact the recruitment of leptomeningeal collaterals. We aimed to assess whether the WMH burden is associated with collateral circulation in patients treated by endovascular thrombectomy for anterior circulation acute ischemic stroke. Methods: Consecutive acute ischemic stroke due to anterior circulation large vessel occlusion and treated with endovascular thrombectomy from January 2015 to December 2017 were included. WMH volumes (periventricular, deep, and total) were assessed by a semiautomated volumetric analysis on fluid-attenuated inversion recovery–magnetic resonance imaging. Collateral status was graded on baseline catheter angiography using the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology grading system (good when ≥3). We investigated associations of WMH burden with collateral status. Results: A total of 302 patients were included (mean age, 69.1±19.4 years; women, 55.6%). Poor collaterals were observed in 49.3% of patients. Median total WMH volume was 3.76 cm 3 (interquartile range, 1.09–11.81 cm 3 ). The regression analyses showed no apparent relationship between WMH burden and the collateral status measured at baseline angiography (adjusted odds ratio, 0.987 [95% CI, 0.971–1.003]; P =0.12). Conclusions: WMH burden exhibits no overt association with collaterals in large vessel occlusive stroke.

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Section: Clinical and Population Sciencesmentioning

confidence: 99%

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confidence: 99%

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White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke

Derraz

Abdelrady

Gaillard

et al. 2021

Stroke

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“…Apart from that, Shang and colleagues [ 58 ] revealed that LA severity combined with FLAIR vascular hyperintensity (FVH), both markers of poor collateral flow, in patients with middle cerebral artery (MCA) strokes predict poor early stroke outcome. LA is considered a composite marker of tissue perfusion and tissue susceptibility to ischemia, as research has exhibited links between LA severity and altered reactivity in response to reduced blood flow of penetrating, small arteries originating in pial vessels and supplying the white matter.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Utility of Leukoaraiosis as a Prognostic Indicator in Ischemic Stroke Patients

Christidi

Tsiptsios

Sousanidou

et al. 2022

Neurology International

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Stroke constitutes a major cause of functional disability with increasing prevalence among adult individuals. Thus, it is of great importance for both clinicians and stroke survivors to be provided with a timely and accurate prognostication of functional outcome. A great number of biomarkers capable of yielding useful information regarding stroke patients’ recovery propensity have been evaluated so far with leukoaraiosis being among them. Literature research of two databases (MEDLINE and Scopus) was conducted to identify all relevant studies published between 1 January 2012 and 25 June 2022 that dealt with the clinical utility of a current leukoaraiosis as a prognostic indicator following stroke. Only full-text articles published in English language were included. Forty-nine articles have been traced and are included in the present review. Our findings highlight the prognostic value of leukoaraiosis in an acute stroke setting. The assessment of leukoaraiosis with visual rating scales in CT/MRI imaging appears to be able to reliably provide important insight into the recovery potential of stroke survivors, thus significantly enhancing stroke management. Yielding additional information regarding both short- and long-term functional outcome, motor recovery capacity, hemorrhagic transformation, as well as early neurological deterioration following stroke, leukoaraiosis may serve as a valuable prognostic marker poststroke. Thus, leukoaraiosis represents a powerful prognostic tool, the clinical implementation of which is expected to significantly facilitate the individualized management of stroke patients.

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The impact of FLAIR vascular hyperintensity on clinical severity and outcome

Huang

2020

Neurol Sci

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Association of FLAIR vascular hyperintensity and acute MCA stroke outcome changes with the severity of leukoaraiosis

Cited by 4 publications

References 37 publications

White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke

White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke

The Clinical Utility of Leukoaraiosis as a Prognostic Indicator in Ischemic Stroke Patients

The impact of FLAIR vascular hyperintensity on clinical severity and outcome

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