Association of Fibrinogen with Severity of Stable Coronary Artery Disease in Patients with Type 2 Diabetic Mellitus

Abstract

Background. Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. Methods. A total of consecutive 373 diabetic patients with typical angina pectoris who received coronary angiography were enrolled and classified into three groups by tertiles of Gensini score (GS, low group <8; intermediate group 8~28; high group >28). The relationship between fibrinogen and GS was evaluated. Results. There were correlations of fibrinogen with hemoglobin A1c, C-reactive protein, and GS (r = 0.17, r = 0.52, and r = 0.21, resp.; all P < 0.001). Area under the receivers operating characteristic curve of fibrinogen was 0.62 (95% CI 0.56–0.68, P < 0.001) for predicting a high GS. Multivariate analysis suggested that plasma fibrinogen was an independent predictor of a high GS for diabetic patients (OR = 1.40, 95% CI 1.04–1.88, and P = 0.026) after adjusting for traditional risk factors of CAD. Conclusions. The present data indicated that plasma fibrinogen, a readily measurable systematic inflammatory marker, appeared to be an independent predictor for the severity of CAD in diabetic patients.

Higher Fibrinogen Level is Independently Linked with the Presence and Severity of New-Onset Coronary Atherosclerosis among Han Chinese Population

“…Furthermore, our data suggested that a cut-off value of 3.21 g/L may be useful in predicting the severity of coronary stenosis. The findings were in consistent with previous studies among Western population [27] and our recent study in Chinese patients with CAD and diabetes mellitus [28] . However, those previous studies were limited by the lack of strict assessment system of coronary atherosclerosis or the relatively small sample size.…”

Raman spectroscopic analysis of high molecular weight proteins in solution – considerations for sample analysis and data pre-processing

“…[20][21][22] Many clinical studies have consistently shown elevated levels of fibrinogen in patients with cardiovascular disease and thrombosis. [23][24][25] The conventional test kits available in a hospital for plasma/ serum analysis suffer from long time delays for the availability of results due to the need of specialised laboratories, which may in turn delay the therapy, and prolong patient anxiety. The potential of vibrational spectroscopy techniques coupled with multivariate analysis techniques have been previously investigated for a range of clinical applications.…”

Plasma Big Endothelin-1 Level and the Severity of New-onset Stable Coronary Artery Disease

“…Hence, understanding its predictors would greatly aid in disease prevention and treatment, and the possible relationships between various plasma markers and CAD have intensively been investigated [2][3][4][5] . Among these markers, endothelin 1 (ET-1) has been demonstrated to play a role in endothelial dysfunction and inflammation 6) , both of which are actively involved in the pathophysiology of the onset and progression of CAD, from the formation of atherosclerotic plaque to the development of acute coronary syndrome (ACS) and heart failure following myocardial infarction 7) .…”