Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province

Jiang, Yongdong; Sun, Shanshan; Wei, Wei; Ren, Yanlv; Liu, Jing; Pang, Da

doi:10.18632/oncotarget.5850

Cited by 22 publications

(27 citation statements)

References 24 publications

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“…SNP rs351855 corresponds to the Gly388Arg substitution, whereas SNP rs1966265 corresponds to the Ile10Val substitution. Their effects on protein structure and function may differ, and in the present study, there was no significant association between rs1966265 and FGFR4 protein expression. Moreover, rs1966265 had no obvious effect on breast cancer prognosis.…”

Section: Discussioncontrasting

confidence: 70%

“…The FGFR4 SNP rs351855, corresponding to the Gly388Arg substitution, is an important polymorphism that is biologically functional and can affect the transmembrane domain of the protein . FGFR4 is overexpressed in many cancers, including gastric cancer, non‐small cell lung cancer, colorectal cancer, and breast cancer .…”

Section: Discussionmentioning

confidence: 99%

“…16 We previously reported that FGFR4 SNPs (rs1966265 and rs351855) increase the risk of breast cancer in a northern Chinese population. 17 Although prognostic implications of FGFR4 polymorphisms in breast cancer have been reported, no significant correlation between them has been reported. 18,19 Therefore, in this study, we investigated the association between FGFR4 polymorphisms and breast cancer prognosis through genotyping and immunohistochemistry analyses.…”

Section: Funding Informationmentioning

confidence: 99%

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Prognostic implications of fibroblast growth factor receptor 4 polymorphisms in primary breast cancer

Wei

You

Sun

et al. 2018

Molecular Carcinogenesis

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Fibroblast growth factor receptor 4 (FGFR4) belongs to the receptor tyrosine kinase (RTK) family, and FGFR4 polymorphisms have been implicated in both normal development and cancer, including breast cancer. In the present study, we investigated correlations between polymorphisms in FGFR4 and breast cancer prognosis. The FGFR4 SNPs rs1966265 and rs351855 were genotyped in 747 breast cancer patients using the SNaPshot method. FGFR4 protein expression was detected by immunohistochemistry in 339 samples. SNP rs351855 was correlated with FGFR4 protein expression under dominant and co-dominant models. Lymph node metastasis (LNM), ER (estrogen receptor) status, and molecular subtype were associated with high FGFR4 expression. Univariate analysis revealed rs351855 (CC/CT: P = 0.027, CC/TT: P < 0.001, CC/CT + TT: P = 0.005) to be a prognostic predictor, and multivariate analysis indicated rs351855 (CC/TT: P = 0.005) to be an independent prognostic factor. Kaplan-Meier survival analysis showed that high FGFR4 protein expression was associated with a poor prognosis. SNP rs351855 was correlated with worse outcomes, with a dose-dependent effect. The results of this study show that FGFR4 SNP rs351855 is associated with up-regulation of FGFR4 protein expression and a worse prognosis in breast cancer.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Funding Informationmentioning

confidence: 99%

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Prognostic implications of fibroblast growth factor receptor 4 polymorphisms in primary breast cancer

Wei

You

Sun

et al. 2018

Molecular Carcinogenesis

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“…18,38 Furthermore, functional germline mutation such as FGFR4-G388R has been described in lung cancer and predicted poor survival in lung adenocarcinoma patients 39,40 and recent genome-wide association studies have suggested that FGFR genes polymorphisms are associated with an increased risk of developing breast cancer. 41,42 The germline mutations that we identified were mostly localized to the tyrosine kinase and extracellular ligand binding domains, indicating likely pathogenicity as has been observed for other germline mutation of proto-oncogenes, for example RET mutations causing multiple endocrine neoplasia type 2. 43 To date, few studies have comprehensively evaluated the relationships of FGFR mutations with patient features and clinical outcomes in SQCC.…”

Section: Discussionmentioning

confidence: 52%

FGFR genes mutation is an independent prognostic factor and associated with lymph node metastasis in squamous non-small cell lung cancer

Shi

Pan

et al. 2018

Cancer Biology & Therapy

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2018) FGFR genes mutation is an independent prognostic factor and associated with lymph node metastasis in squamous non-small cell lung cancer, Cancer ABSTRACT Targeting FGFRs is one of the most promising therapeutic strategies in squamous non-small cell lung cancer (SQCC). However, different FGFR genomic aberrations can be associated with distinct biological characteristics that result in different clinical outcomes or therapeutic consequences. Currently, the full spectrum of FGFR gene aberrations and their clinical significance in SQCC have not been comprehensively studied. Here, we used Next-generation sequencing to investigate the presence of FGFR gene mutations in 143 tumors from patients with stage I, II or III SQCC and who had not been treated with chemotherapy or radiotherapy prior to surgery. FGFR gene mutations were identified in 24 cases, resulting in an overall frequency of 16.9%. Among the mutations, 7% (10/143) were somatic mutations, and 9.8% (14/143) germline mutations. FGFR mutations were significantly associated with an increased risk of lymph node metastasis. SQCC patients with a FGFR somatic mutation had shorter OS (overall survival, log rank P = 0.005) and DFS (disease-free survival，log rank P = 0.004) compared with those without an FGFR mutation. The multivariate analysis confirmed that a somatic mutation was an independent poor prognostic factor for OS (HR: 4.26, 95% CI: 1.49-12.16, P = 0.007) and DFS (HR: 3.16, 95% CI: 1.20-8.35, P = 0.020). Our data indicate that FGFR genes mutation is an independent prognostic factor and associated with lymph node metastasis in stage I to III Chinese SQCC patients. ARTICLE HISTORY

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“…Emerging studies on different kinds of cancers have provided abundant evidence for SNPs serving as predicting roles [4,5]. Further studies on SNPs in osteosarcoma will also be valuable in identifying potential prognostic biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Ras-Association Domain Family 1 Isoform A (RASSF1A) Gene Polymorphism rs1989839 is Associated with Risk and Metastatic Potential of Osteosarcoma in Young Chinese Individuals: A Multi-Center, Case-Control Study

Zhan

Chen

2016

Med Sci Monit

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BackgroundThe ras-association domain family 1 isoform A (RASSF1A) gene serves as a bona fide tumor suppressor gene. The polymorphisms in RASSF1A were previously reported to be associated with the risk of solid malignant tumors. We hypothesized herein that RASSF1A gene polymorphisms are involved in the risk and prognosis of osteosarcoma (OS).Material/MethodsWe recruited 279 young OS cases and 286 tumor-free controls from the east Chinese population. Five tagSNPs of RASSF1A gene (rs2236947A/C, rs2073497A/C, rs1989839C/T, rs72932987C/T, and rs4688728G/T) were genotyped. DNA was isolated from blood samples and then underwent PCR analysis for genotyping.Resultsrs1989839C/T is an important predictor of osteosarcoma risk and outcome. The CT genotype of rs1989839 is highly related to elevated risk of osteosarcoma. Furthermore, rs1989839C/T is also associated with the Enneking stage of osteosarcoma and risk of lung metastasis. One of the other 4 SNPs, rs2236947A/C, shows a borderline significance in predicting osteosarcoma risk.ConclusionsOur study is the first to prove that RASSF1A gene polymorphisms may potentially be predictive for osteosarcoma risk and prognosis.

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Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province

Cited by 22 publications

References 24 publications

Prognostic implications of fibroblast growth factor receptor 4 polymorphisms in primary breast cancer

Prognostic implications of fibroblast growth factor receptor 4 polymorphisms in primary breast cancer

FGFR genes mutation is an independent prognostic factor and associated with lymph node metastasis in squamous non-small cell lung cancer

Ras-Association Domain Family 1 Isoform A (RASSF1A) Gene Polymorphism rs1989839 is Associated with Risk and Metastatic Potential of Osteosarcoma in Young Chinese Individuals: A Multi-Center, Case-Control Study

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