Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

Freiberger, Tomáš; Grodecká, Lucie; Ravčuková, Barbora; Kuřecová, Barbora; Postránecká, Věra; Vlček, Jiřı́; Jarkovský, Jiří; Thon, Vojtěch; Litzman, Jiří

doi:10.1016/j.clim.2010.05.006

Cited by 35 publications

(27 citation statements)

References 21 publications

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“…This result is in line with the recent evidences demonstrating a central role of FcRn in anti-tumor immune-surveillance [18]. It also raises questions on the role of FcRn in non-cancer lung diseases, since lower levels of FCGRT mRNA were also described in bronchiectasis and lung fibrosis, correlating with the extent of lung abnormalities [28]. …”

Section: Discussionsupporting

confidence: 85%

Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis

et al. 2016

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Lung cancer is the leading cause of cancer-related death worldwide. Although the recommended tumor, node and metastasis (TNM) classification and stage determination are important to select therapeutic options for patients with non-small cell lung carcinoma (NSCLC), additional molecular markers are required to indicate the prognosis, in particular within a specific stage, and help with the management of patients.Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-cancerous and NSCLC lung tissues and evaluated its prognostic value in overall survival for patient with NSCLC. FcRn expression was determined at both mRNA and protein levels on cancerous and adjacent non-cancerous tissues from 80 NSCLC patients. In NSCLC, FcRn was mainly found in resident and tumor infiltrating immune cells. The corresponding mRNA and protein were significantly less abundant in lung tumor than non-cancerous tissue. Moreover, analysis of our cohort and datasets from the public data bases show that FCGRT mRNA down-regulation is a robust and independent, unfavorable predictive factor of NSCLC patient survival. We conclude that FCGRT mRNA expression may be a useful additional marker for immunoscoring, reflecting tumor immune system, and help in the decision-making process for NSCLC patients.

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Section: Discussionsupporting

confidence: 85%

Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis

et al. 2016

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“…Besides its involvement in the transfer of maternal IgG to the foetus or neonate, FcRn acts as a homeostatic receptor for serum stabilization of IgG in adults. Recently, an inverse correlation between FCRN mRNA expression in peripheral blood mononuclear cells and the extent of bronchiectasis in CVID has been demonstrated [44]. These authors highlighted a faster decline in serum IgG concentration during the 2nd week after IVIg infusion in patients with lower FCRN mRNA level [44].…”

Section: Resultsmentioning

confidence: 99%

“…Recently, an inverse correlation between FCRN mRNA expression in peripheral blood mononuclear cells and the extent of bronchiectasis in CVID has been demonstrated [44]. These authors highlighted a faster decline in serum IgG concentration during the 2nd week after IVIg infusion in patients with lower FCRN mRNA level [44]. Whether proper regulation of gene expression by circulating IgG may be affected in CVID, and whether altered function of FcRn receptor may contribute to the disease may be an emerging scenario in CVID.…”

Section: Resultsmentioning

confidence: 99%

Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy

Spadaro

D'Orio

Genovese

et al. 2011

BioMed Research International

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Common variable immunodeficiency is the most common form of symptomatic primary antibody failure in adults and children. Replacement immunoglobulin is the standard treatment of these patients. By using a differential proteomic approach based on 2D-DIGE, we examined serum samples from normal donors and from matched, naive, and immunoglobulin-treated patients. The results highlighted regulated expression of serum proteins in naive patients. Among the identified proteins, clusterin/ApoJ serum levels were lower in naive patients, compared to normal subjects. This finding was validated in a wider collection of samples from newly enrolled patients. The establishment of a cellular system, based on a human hepatocyte cell line HuH7, allowed to ascertain a potential role in the regulation of CLU gene expression by immunoglobulins.

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“…It has been postulated that the beneficial effect of IVIg in antibody-mediated autoimmune disorders is based on the accelerated catabolism of auto-antibodies [33,34]. The mechanisms act on the catabolism of IgG involving Fc receptor neonate binding protein (FcRn) [34,35]. IVIg affects IgG's half-life whereas IgM and IgA levels are unaffected.…”

Section: Discussionmentioning

confidence: 99%

Intravenous immunoglobulin treatment on anti-GM1 antibodies associated neuropathies inhibits cholera toxin and galectin-1 binding to ganglioside GM1

Peng¹

2012

Immunology Letters

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Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

Cited by 35 publications

References 21 publications

Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis

Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis

Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy

Intravenous immunoglobulin treatment on anti-GM1 antibodies associated neuropathies inhibits cholera toxin and galectin-1 binding to ganglioside GM1

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