Association of fasting blood glucose to high-density lipoprotein cholesterol ratio with short-term outcomes in patients with acute coronary syndrome

Abstract

Background Biochemical markers are crucial for determining risk in coronary artery disease (CAD) patients; however, the relationship between fasting blood glucose to high-density lipoprotein cholesterol (FG/HDL-C) ratio and short-term outcomes in acute coronary syndrome (ACS) patients remains unknown. Therefore, we have investigated the relationship between the FG/HDL-C ratio and short-term outcomes in ACS patients. Methods We used data from a pragmatic, stepped-wedge, cluster-randomized clinical trial to perform a post hoc analysis. A total of 11,284 individuals with ACS were subdivided into quartiles according to their FG/HDL-C ratios. We used a multivariate logistic regression model, two-piecewise linear regression model, and generalized additive model (GAM) to evaluate the relationship between the FG/HDL-C ratio and short-term outcomes (major adverse cardiovascular events [MACEs] and cardiovascular [CV] death within 30 days). Results The FG/HDL-C ratio was remarkably linked to an enhanced risk of MACEs and CV death in individuals with ACS in the highest quartile (MACEs, odds ratio [OR]: 1.49; 95% confidence interval [CI], [1.11, 1.99]; P < 0.01; CV death, OR: 1.69; 95% CI, [1.01, 1.41]; P = 0.04). The GAM suggested that the relationship between the FG/HDL-C ratio and MACEs and CV death was non-linear. The two-piecewise linear regression model demonstrated that the threshold values were 3.02 and 3.00 for MACEs and CV death, respectively. Conclusions A higher FG/HDL-C ratio is associated with a higher risk of MACEs and CV death in patients with ACS.

Association between nontraditional lipid parameters and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study

“…A secondary analysis of a public database indicated a signi cant correlation between the highest quartile of GHR and the risk of 30-day MACCEs occurrence in ACS patients undergoing coronary revascularization. In the population with GHR exceeding 3.02, there is a notable positive correlation between GHR and the risk of MACCEs (OR: 1.12, 95% CI: 1.07-1.17, P < 0.01) (41). There are relative limited data analyzing the prognosis value of GHR in patients with PCI.…”

Karakteristik Pasien Nstemi (Non St Segment Elevation Myocardial Infarction) Dan Uap (Unstable Angina Pectoris) Yang Dirawat Inap Di Rs Pku Muhammadiyah Gamping Periode 1 Januari 2018 - 31 Desember 2020

“…Jenis riwayat penyakit penyerta pasien rawat inap NSTEMI dan UAP di RS PKU Muhammadiyah Gamping periode 2018 -2020 yang memiliki riwayat komorbid dislipidemia adalah 2 pasien (0.9 %). Hasil penelitian terkait dislipidemia menyimpulkan bahwa rasio FG / HDL -C (fasting blood glucose to High -Density Lipoprotein Cholesterol) yang lebih tinggi dihubungkan dengan risiko MACE (Major Adverse Cardiac Events) dan kematian kardiovaskular yang lebih tinggi pada pasien dengan sindrom koroner akut (Deng et al, 2022). Penelitian yang dilakukan oleh Shao et al (2022) menyimpulkan bahwa RC (Remnant Cholesterol) yang meningkat secara signifikan terkait dengan prognosis yang lebih buruk pada pasien diabetes dan non-diabetes dengan sindrom koroner akut.…”