Association of exposure to phthalates with cardiometabolic risk factors in children and adolescents: a systematic review and meta-analysis

Golestanzadeh, Mohsen; Riahi, Roya; Kelishadi, Roya

doi:10.1007/s11356-019-06589-7

Cited by 80 publications

(37 citation statements)

References 93 publications

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“…Previous studies using single-pollutant models have also mostly found MEP to be associated with childhood adiposity [15] and MCNP to be associated with adult adiposity [49]; however, prior evidence largely suggests a lack of association with propylparaben [17][18][19] and inconsistent associations with other biomarkers analyzed in the current study. There is a wide range of demographic characteristics, geographical locations, and ages in the literature, which may explain some inconsistent results.…”

Section: Discussioncontrasting

confidence: 68%

Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort

Berger

Hyland

Ames

et al. 2021

IJERPH

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Exposures to phthalates, parabens, and other phenols are often correlated due to their ubiquitous use in personal care products and plastics. Examining these compounds as a complex mixture may clarify inconsistent relationships between individual chemicals and childhood adiposity. Using data from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a longitudinal cohort of children in Salinas Valley, California (n = 309), we examined biomarkers of 11 phthalate metabolites and 9 phenols, including several parabens and bisphenol A, measured in maternal urine at two time points during pregnancy. We measured child height and weight at age five to calculate the body mass index (BMI) z-scores and overweight/obesity status. The association between prenatal urinary concentrations of biomarkers with the childhood BMI z-score and overweight/obesity status was analyzed using single-pollutant models and two mixture methods: Bayesian hierarchical modeling (BMH) and Bayesian kernel machine regression (BKMR). Urinary concentrations of monoethyl phthalate, monocarboxy-isononly phthalate (metabolites of diethyl phthalate and di-isodecyl phthalate, respectively), and propylparaben were consistently associated with an increased BMI z-score and overweight/obesity status across all modeling approaches. Higher prenatal exposures to the cumulative biomarker mixture also trended with greater childhood adiposity. These results, robust across two methods that control for co-pollutant confounding, suggest that prenatal exposure to certain phthalates and parabens may increase the risk for obesity in early childhood.

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Section: Discussioncontrasting

confidence: 68%

Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort

Berger

Hyland

Ames

et al. 2021

IJERPH

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“…Similar findings have been observed in children with increased MEHP exposure, which was associated with obesity, elevated triglycerides and increased blood pressure in children age 6–18 years old (Amin et al, 2018). Most recently, a meta‐analysis study by Golestanzadeh et al concluded that phthalate exposure was associated with increased cardiometabolic risk factors in children (Golestanzadeh, Riahi, & Kelishadi, 2019).…”

Section: Di‐2‐ethylhexyl Phthalatementioning

confidence: 99%

Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

Ramadan

Cooper

Posnack

2020

Birth Defects Research

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Phthalates and bisphenols are high production volume chemicals that are used in the manufacturing of consumer and medical products. Given the ubiquity of bisphenol and phthalate chemicals in the environment, biomonitoring studies routinely detect these chemicals in 75-90% of the general population. Accumulating evidence suggests that such chemical exposures may influence human health outcomes, including cardiovascular health. These associations are particularly worrisome for sensitive populations, including fetal, infant and pediatric groups-with underdeveloped metabolic capabilities and developing organ systems. In the presented article, we aimed to review the literature on environmental and clinical exposures to bisphenols and phthalates, highlight experimental work that suggests that these chemicals may exert a negative influence on cardiovascular health, and emphasize areas of concern that relate to vulnerable pediatric groups. Gaps in our current knowledge are also discussed, so that future endeavors may resolve the relationship between chemical exposures and the impact on pediatric cardiovascular physiology.

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“…Second, chemicals may transfer from packaging materials to food contents, some of which may have detrimental impacts on cardiometabolic health [39]. Indeed, a cross-sectional study showed that ultra-processed food consumption could increase exposure to phthalates (the synthetic chemicals widely used in food packaging) [40]; a recent Cochrane review further showed a signi cant association between exposure to phthalates and cardiometabolic risk factors [41]. Third, food additives were frequently used in the production of ultra-processed foods [6], and some studies have reported their adverse effects on cardiovascular outcomes.…”

Section: Interpretation and Comparison With Other Studiesmentioning

confidence: 99%

Association of Ultra-processed Food Consumption With Cardiovascular Mortality in the US Population: Long-term Results From a Large Prospective Multicenter Study

Zhong

Yang

Wang

et al. 2020

Preprint

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Background Ultra-processed foods have now become dominant in the global food system. Whether their consumption is associated with cardiovascular mortality remains controversial. Moreover, data on ultra-processed foods and cardiovascular outcomes are scarce in the US population. We aimed to examine the association of ultra-processed food consumption with cardiovascular mortality in a US population. Methods A population-based cohort of 91891 participants was identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Dietary data were collected through a validated 137-item food frequency questionnaire. Ultra-processed foods were defined by the NOVA classification. Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for cardiovascular mortality. Restricted cubic spline regression was used to test nonlinearity. Subgroup analyses were conducted to identify the potential effect modifiers. Results After an average follow-up of 13.5 years (1236049.2 person-years), 5490 cardiovascular deaths were documented, including 3985 heart disease deaths and 1126 cerebrovascular deaths. In the fully adjusted model, participants in the highest vs. the lowest quintiles of ultra-processed food consumption had higher risks of death from cardiovascular disease (HRquintile 5 vs. 1, 1.52; 95% CI, 1.39–1.67) and heart disease (HRquintile 5 vs. 1, 1.70; 95% CI, 1.52–1.89) but not cerebrovascular disease (HRquintile 5 vs. 1, 1.00; 95% CI, 0.80–1.23). A nonlinear dose–response pattern was observed for overall cardiovascular and heart disease mortality (all Pnonlinearity<0.05), with a threshold effect observed at ultra-processed food consumption of 2.5 servings/day and 2.4 servings/day, respectively; below the thresholds, no significant associations were observed for these two outcomes. Subgroup analyses showed that the increased risks of mortality from ultra-processed foods were significantly higher in women than in men (all Pinteraction<0.05). Conclusions High consumption of ultra-processed foods is associated with increased risks of overall cardiovascular and heart disease mortality. These harmful associations may be more pronounced in women. Our findings are needed to be confirmed in other populations and settings.

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Association of exposure to phthalates with cardiometabolic risk factors in children and adolescents: a systematic review and meta-analysis

Cited by 80 publications

References 93 publications

Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort

Prenatal Exposure to Mixtures of Phthalates, Parabens, and Other Phenols and Obesity in Five-Year-Olds in the CHAMACOS Cohort

Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

Association of Ultra-processed Food Consumption With Cardiovascular Mortality in the US Population: Long-term Results From a Large Prospective Multicenter Study

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