Association of exposure to phenols and idiopathic male infertility

Chen, Minjian; Tang, Rong; Fu, Guangbo; Xu, Bin; Zhu, Pengfei; Qiao, Shubin; Chen, Xiaojiao; Xu, Bo; Qin, Yufeng; Lu, Chuncheng; Hang, Bo; Xia, Yankai; Wang, Xinru

doi:10.1016/j.jhazmat.2013.01.061

Cited by 122 publications

(65 citation statements)

References 41 publications

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“…The studies by Chen et al (2013) and Den Hond et al reported null results. Another cross-sectional study from China (Zhu et al 2016) reported some statistically significant results among 24 TCS tertile-specific regression coefficients, but all of these results were observed in the lowest rather the highest tertiles of TCS exposure and the significant associations varied in terms of magnitude and direction.…”

Section: Male Reproductive Endpointsmentioning

confidence: 93%

“…Twenty two studies were cross-sectional and the remaining three (Chen et al 2013;Den Hond et al 2015;Wang et al 2015) used case-control design, but included prevalent rather than incident cases. Tier 2 included 13 publications.…”

Section: Methodsmentioning

confidence: 99%

“…One study conducted in China (Chen et al 2013) observed a significant positive association in one of the two analyses (creatinine-adjusted only), whereas the second study conducted in Belgium (Den Hond et al 2015) reported a null result.…”

Section: Male Reproductive Endpointsmentioning

confidence: 98%

“…Of the 43 studies, 24 were conducted in North America (Wolff et al , 2010(Wolff et al , 2015Clayton et al 2011;You et al 2011;Buttke et al 2012;Savage et al 2012Savage et al , 2014Koeppe et al 2013;Lankester et al 2013;Buser et al 2014;Spanier et al 2014;Adgent and Rogan 2015;Li et al 2015;Ihde et al 2015;Shiue 2015aShiue , 2015bVelez et al 2015;Ashley-Martin et al 2016;Buckley et al 2016;Poole et al 2016;Scinicariello and Buser 2016;Smarr et al 2017;Geer et al 2017), two studies in the Caribbean (Watkins et al 2015;Aker et al 2016), 10 studies in Europe (Allmyr et al 2009;Chevrier et al 2012;Philippat et al 2012Philippat et al , 2014Bertelsen et al 2013;Buhl et al 2014;Den Hond et al 2013, 2015Geens et al 2015;Lassen et al 2016), four in Asia (Chen et al 2013;Wang et al 2015;Xue et al 2015;Zhu et al 2016), and three in Australia (Cullinan et al 2012(Cullinan et al , 2015a…”

Section: Overview Of Studiesmentioning

confidence: 99%

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Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain -overall design, exposure assessment, and data analysis -was categorized according to three tiers where Tier 1 indicated the highest quality. We also examined consistency of methods, results and reporting as considerations for weight of evidence (WOE) assessment. Studies were considered sufficiently comparable if they addressed the same or similar research questions. Forty-two studies met the criteria for inclusion. Only one randomized cross-over clinical trial of TCS was assigned to Tier 1 for all three domains. Most other studies were assigned to Tier 3 for at least one domain. Although the available literature examined more than 100 different health endpoints and reported hundreds of different measures of association, few studies were considered comparable. For reported measures of association, most were not significantly different from the null; the few statistically significant results represented isolated findings without a discernable across-or within-study pattern. We conclude that the current body of epidemiologic literature does not allow a meaningful WOE assessment due to methodological limitations of individual studies and lack of inter-study consistency. On the other hand, methodologically stronger studies may be used to inform future research. ARTICLE HISTORY

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Section: Male Reproductive Endpointsmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Male Reproductive Endpointsmentioning

confidence: 98%

Section: Overview Of Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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“…Significantly, EDs has been suggested to exhibit adverse effects not only on endocrine homeostasis but also on the male reproductive function (Guerrero-Bosagna and Skinner 2014). Especially the issue of male infertility of the xenoestrogen NP is increasingly a matter of public concern (Chen et al 2013;Verderame and Limatola 2015).…”

Section: Introductionmentioning

confidence: 99%

4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells

Duan

Quan

et al. 2017

Toxicology Letters

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The estrogenic chemical 4-nonylphenol (NP) is known to impair testicular devolopment and spermatogenesis in rodents. The objective of this study was to explore the effects of NP on autophagy induction and AMPK-mTOR signaling pathway in Sertoli cells (SCs), which are the "nursemaid cells" for meiosis of spermatocytes. In this study we exposed 7-week-old male rats to NP by intra-peritoneal injection at 0, 20, 50 or 100 mg/kg body weight/2 days for 20 consecutive days. Our results showed that exposure to NP dose-dependently induces the formation of autophagosomes in SCs, increases the expression of Beclin-1, the conversion of LC3-I to LC3-II and the mRNA expression of Atg3, Atg5, Atg7 and Atg12 in testis, and these effects are concomitant with the activation of AMPK, and the suppression of TSC2-mTOR-p70S6K/4EBP1 signaling cascade in testis. Furthermore, 10 µM Compound C or AMPKα1 siRNA pre-treatment effectively attenuated autophagy and reversed AMPK-mTOR-p70S6K/4EBP1 signaling in NP-treated SCs. Co-treatment with 1 mM AICAR remarkably strengthened NP-induced autophagy and mTOR inhibition in SCs. Together, these data suggest that NP stimulates Sertoli cell autophagy and inhibits mTOR-p70S6K/4EBP1 activity through AMPK activation, which is the potential mechanism responsible for the regulation of testis function and differentiation following NP exposure.

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4‐tert‐Octylphenol [MAK Value Documentation in German language, 2016]

Hartwig

2016

The MAK‐Collection for Occupational Health and Safety

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4‐tert‐Octylphenol The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 4‐tert‐octylphenol to derive a maximum concentration at the workplace (MAK value), considering all toxicity endpoints with the exception of developmental toxicity. Available unpublished study reports and publications are described in detail. 4‐tert‐Octylphenol is an endocrine‐active substance that might impair fertility. Despite appropriate investigations, no such effects and no influence on fertility were seen in a two‐generation feeding study in rats after doses of up to 250 mg/kg bw. In this study and in a 90‐day study, the most sensitive effect is delayed body weight development with NOAEL and LOAEL of 15 and 20 mg/kg bw and day, respectively. In a Draize test, 4‐tert‐octylphenol is a severe eye irritant. Because there are no inhalation studies investigating possibly irritating effects on the airways, bisphenol A, which is also a strong eye irritant, is used as a read‐across and a MAK value of 0.5 ml 4‐tert‐octylphenol/m 3 (4 mg/m 3 ) is thus established. The dose taken up at this concentration is clearly below the equipotent dose for 4‐tert‐octylphenol calculated from the human LOAEL for ethinylestradiol and 17β‐estradiol. Since the critical effect of 4‐tert‐octylphenol is local, Peak Limitation Category I is assigned. In analogy to bisphenol A, an excursion factor of 1 has been set. The substance is not genotoxic. Skin contact is not expected to lead to systemic toxicity or contact sensitization.

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Association of exposure to phenols and idiopathic male infertility

Cited by 122 publications

References 41 publications

Systematic review of the literature on triclosan and health outcomes in humans

Systematic review of the literature on triclosan and health outcomes in humans

4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells

4‐tert‐Octylphenol [MAK Value Documentation in German language, 2016]

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