Association of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition

Mitchell, Ellen Sullivan; Farin, Frederico M.; Stapleton, Patricia L.; Tsai, Jesse; Tao, Eunice Y.; Smith-DiJulio, Kathleen; Woods, Nancy Fúgate

doi:10.1097/gme.0b013e31804d2406

Cited by 41 publications

(45 citation statements)

References 16 publications

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“…Of the six studies reporting continuous outcomes, only one (Stavrou et al, 2002) described a positive result, suggesting increased AAM among US women carrying the A allele and decreased AAM among those with the G allele. By contrast, the other studies examined demonstrated no significant difference between ESR1 rs9340799 genotypes in terms of AAM (Gorai et al, 2003;Xu et al, 2005;Mitchell et al, 2008;Kulik-Rechberger et al, 2010;Silva et al, 2010). Besides the small sample sizes, differences in ethnicity may be a major reason for such disagreement.…”

Section: Discussioncontrasting

confidence: 38%

“…Human ESR1 comprises eight exons spanning more than 300 kb of chromosome 6q25.1. A number of studies have investigated potential associations between ESR1 polymorphisms and AAM in humans (Stavrou et al, 2002;Gorai et al, 2003;Xu et al, 2005;Mitchell et al, 2008;Kulik-Rechberger et al, 2010;Silva et al, 2010). However, their results have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Lack of association between the ESR1 rs9340799 polymorphism and age at menarche: a meta-analysis

et al. 2016

Genet. Mol. Res.

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ABSTRACT. It has been reported that the estrogen receptor alpha (ESR1) rs9340799 polymorphism is associated with age at menarche (AAM). However, recent investigations have generated inconsistent results. This study aimed to establish a more precise estimation of the association between this polymorphism and AAM. A meta-analysis was conducted based on an in silico literature search using PubMed. Six studies presenting continuous data, including ESR1 rs9340799 genotype frequencies, were selected. Effect size was estimated using Hedges' adjusted g with 95% confidence intervals (CIs), which were calculated based on the standardized mean difference between groups of subjects and different genotypes. No evidence of an association 187, 95%CI = -0.032-0.406, P = 0.095). Moreover, a funnel plot generated using this data was found to be symmetrical using the Egger (P = 0.797) and Begg tests (P = 0.851), indicating the absence of publication bias. In summary, our meta-analysis shows that the ESR1 rs9340799 polymorphism is not a significant, independent contributing factor to AAM. To validate this finding, further studies involving larger numbers of participants are needed.

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Section: Discussioncontrasting

confidence: 38%

Section: Introductionmentioning

confidence: 99%

Lack of association between the ESR1 rs9340799 polymorphism and age at menarche: a meta-analysis

et al. 2016

Genet. Mol. Res.

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“…Semakin muda usia menarche ibu maka semakin muda pula usia menarche anak. Adanya hubungan ini diduga berkaitan dengan lokus pengatur estrogen yang diwariskan (Mitchell 2008 Tabel 6. Sebaran Subjek menurut Aktivitas Fisik subjek mengalami siklus menstruasi >35 hari.…”

Section: Menstruasiunclassified

Asupan Zat Gizi Dan Status Gizi Pada Remaja Putri Yang Sudah Dan Belum Menstruasi

Christianti

Khomsan

2012

J Gizi Pangan

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Keywords: BMI/age, girls, menstruation, nutrient intake, percent body fat ABSTRAKTujuan penelitian ini adalah untuk menganalisis asupan zat gizi dan status gizi pada remaja putri yang sudah dan belum menstruasi. Survei ini dilaksanakan pada April-September 2012 di Sekolah Dasar (SD) dan Sekolah Menengah Pertama (SMP) di Bogor. Jumlah subjek terdiri dari 35 orang yang sudah menstruasi dan 35 orang yang belum menstruasi dan dipilih melalui screening. Hasil penelitian menunjukkan bahwa persentase terjadinya menstruasi pada siswi di sekolah kota lebih besar (28.0%) dibandingkan dengan di kabupaten (25.1%). Sebanyak 57.1% subjek mengalami menarche pada usia 10 tahun. Rata-rata asupan zat gizi subjek yang sudah dan belum menstruasi masih berada di bawah AKG (<90%). Status gizi overweight lebih banyak ditemukan pada subjek yang sudah menstruasi (14.3%) dibandingkan dengan subjek yang belum menstruasi (2.9%). Demikian pula dengan hasil pengukuran persen lemak tubuh yang menunjukkan bahwa kategori lemak tubuh overweight dan obesitas lebih banyak ditemukan pada subjek yang sudah menstruasi (17.2%) dibandingkan dengan subjek yang belum menstruasi (2.9%). Hasil independent sample t-test menunjukkan adanya perbedaan yang signifikan pada usia, asupan energi, dan kalsium, IMT/U, serta persen lemak tubuh antara subjek yang sudah dan belum menstruasi (p<0.05).Kata kunci: asupan zat gizi, IMT/U, menstruasi, persen lemak tubuh, remaja putri

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“…Entretanto, alguns investigadores já avaliaram estes genes em relação à idade da menarca (Gorai et al, 2003;Haiman et al,1999;Mitchell et al, 2008).…”

Section: Cyp17 -Msp1aunclassified

“…Outra possibilidade seria que este polimorfismo não participasse do determinismo da puberdade. De fato, Mitchell et al (2008) estudaram 152 mulheres brancas e concluíram que o polimorfismo do CYP1B1 não está associado a idade da menarca.…”

Section: Cyp17 -Msp1aunclassified

Análise dos genes CYP1A1,CYP1B1 e CYP17 em meninas com puberdade precoce central

Matsuzaki¹

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Association of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition

Cited by 41 publications

References 16 publications

Lack of association between the ESR1 rs9340799 polymorphism and age at menarche: a meta-analysis

Lack of association between the ESR1 rs9340799 polymorphism and age at menarche: a meta-analysis

Asupan Zat Gizi Dan Status Gizi Pada Remaja Putri Yang Sudah Dan Belum Menstruasi

Análise dos genes CYP1A1,CYP1B1 e CYP17 em meninas com puberdade precoce central

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