Association of estrogen receptor alpha and collagen type I alpha 1 gene polymorphisms with bone mineral density in postmenopausal women

Erdoğan, Müjgan Özdemir; Yıldız, Hatice; Artan, Sevilhan; Solak, Mirsala; Taşçıoğlu, Funda; Dündar, Ümit; Eser, Betül; Çolak, Ertuğrul

doi:10.1007/s00198-010-1312-4

Cited by 27 publications

(12 citation statements)

References 23 publications

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“…In addition, a recent study using quantitative computed tomography (QCT) demonstrated that estrogen deficiency is closely related to bone loss in the cortical area but not in the trabecular area [33]. Meanwhile, several studies have investigated the relationship between BMD at each site and genetic polymorphisms, such as the estrogen receptor-alpha and collagen-type I alpha 1 genes [34], or the sex hormone-binding globulin gene [35]. These genome-wide association studies provide much more information about site-, age-, and gender-specific genetic effects on BMD [36].…”

Section: Discussionmentioning

confidence: 98%

Z-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008–9

et al. 2015

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The premenopausal period is important for bone health and prevention of future fractures, but measuring bone mineral density (BMD) at only one site may not be sufficient to determine therapeutic strategies for low BMD in premenopausal women due to the presence of Z-score discordance. In this study, we investigated Z-score discordance in addition to contributing factors of idiopathic low BMD in healthy premenopausal Korean women. We studied 3003 premenopausal women aged 18-50 years, without secondary causes for low BMD and history of fragility fracture, who had participated in the Fourth Korean National Health and Nutrition Examination Surveys (2008-2009). Low body mass index (BMI), low vitamin D level, and low body muscle mass were associated with low BMD even in premenopausal women. Risk factors differed depending on the anatomic site. Low BMI and low vitamin D level were risk factors for low femoral neck BMD (FN-BMD), but not for low lumbar spine BMD (LS-BMD). Only total muscle mass had a slight effect on low LS-BMD. Z-score discordance was much higher than expected, in 75 and 73.8 % of the low LS-BMD and low FN-BMD groups, respectively. Our findings suggest the need to consider BMD discordance in premenopausal women and also to provide information on correctable factors affecting low BMD in younger populations. Long-term follow-up is needed to evaluate the possible effect of Z-score discordance on the prognosis of osteoporosis and subsequent fracture risk.

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Section: Discussionmentioning

confidence: 98%

Z-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008–9

et al. 2015

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“…Conversely, some studies are in complete disagreement with the model which provides a direct FSH regulation of the bone mass [164][165][166]. The presence of direct transcriptional targets of sex steroid hormones in bone [167] and the evidence of a clear association between estrogen receptors subtypes with the features of the bone metabolism [168][169][170][171][172][173][174][175], suggest that gonadotropins and their receptors do not have a predominant role in regulating the bone turnover mechanisms. Finally, a prospective study performed on postmenopausal women treated with a GnRH agonist, demonstrated that suppression of serum FSH levels does not reduce markers of bone resorption, providing a final, strong evidence that FSH does not directly regulates bone resorption [176].…”

Section: Fshr Polymorphisms On Bonementioning

confidence: 98%

Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function

Casarini

Pignatti

Simoni

2011

Rev Endocr Metab Disord

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Gonadotropins, the action of which is mediated at the level of their gonadal receptors, play a key role in sexual development, reproductive functions and in metabolism. The involvement of the gonadotropins and their receptor genotypes on reproductive function are widely studied. A large number of gonadotropins and their receptors gene polymorphisms are known, but the only one considerable as a clear, absolute genetic marker of reproductive features or disfunctions is the FSHR Asn680Ser polymorphism, since it modulates ovarian response to FSH. The aim of these studies would to be the prediction of the genetic causes of sex-related diseases to enable a customized clinical setting based on individual response of patients undergoing gonadotropin stimulation. In this review we discuss the latest information about the effects of polymorphisms of the gonadotropins and their receptor genes on reproductive functions of both male and female, and discuss their patho-physiological implications.

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“…LS is an age-related disease based on osteoporosis. Recent studies suggest that estrogen receptor alpha and collagen type I alpha 1 gene polymorphisms are related with female osteoporosis [17]. Since LS is common in the elderly, it is difficult to determine to what extent LS contributes to urinary retention.…”

Section: Pol Scientificmentioning

confidence: 99%

Neurologic diseases that cause female urinary retention

Nakamura

Sakakibara

Sugiyama

et al. 2016

Bladder

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A B S T R A C T OBJECTIVE:The pathogenesis of female urinary retention is not well known. Hence, we systematically investigated the frequency of diseases that underlie female urinary retention in a urodynamic laboratory. METHODS:We analyzed data from 450 consecutive female patients. Data registries included the diagnosis, lower urinary tract symptom questionnaires, urodynamic study results, and neurologic exam observations. Complete urinary retention is defined as mean post-void residual (PVR) urine volume > 100 ml with no voluntary void at all; whereas incomplete urinary retention is defined as mean PVR urine volume > 100 ml after voluntary partial void. RESULTS:Sixty of the 450 female patients visiting our lab (13%) had urinary retention with 4 (6.7%) of these having complete retention and 56 (93.3%) having incomplete retention. The most common underlying disease in these 60 patients was lumbar spondylosis (LS), 38.3% (with 16 patients having LS alone and 7 having LS & diabetic distal polyneuropathy [DPN]), multiple system atrophy (MSA), 18.3%, and DPN, 14.4% (with 2 patients having DPN alone and 7 having LS & DPN), followed by drug-induced retention (e.g., by antidepressants), 8.3%, acute myelitis of possible demyelinating origin, 5.0%, and other etiologies. An underactive detrusor was the major urodynamic findings in those patients. CONCLUSIONS:The present study revealed that common etiologies for female urinary retention are neurologic, e.g., an underactive detrusor due to MSA, age-related LS, and lifestyle-related DPN. Therefore LS and DPN, both common diseases, should also become major treatment targets in order to maximize patients' quality of life.

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Association of estrogen receptor alpha and collagen type I alpha 1 gene polymorphisms with bone mineral density in postmenopausal women

Abstract: In conclusion, it was designated that ERα gene PvuII polymorphism was effective on average lumbar vertebra BMD value in postmenopausal women of our study group.

Cited by 27 publications

References 23 publications

Z-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008–9

Z-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008–9

Effects of polymorphisms in gonadotropin and gonadotropin receptor genes on reproductive function

Neurologic diseases that cause female urinary retention

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