Association of estrogen receptor alpha gene polymorphisms with metabolic syndrome in Egyptian women

Ghattas, Maivel H.; Mehanna, Eman T.; Mesbah, Noha M.; Abo-Elmatty, Dina M.

doi:10.1016/j.metabol.2013.05.014

Cited by 18 publications

(16 citation statements)

References 27 publications

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“…Clearly, it now becomes important to understand how female VMH VL functional modules acquire their sex-specific properties and how they interact to coordinate reproduction and metabolism. Ultimately, the existence of a similar estrogen-sensitive locomotion module in women could be relevant for understanding the metabolic consequences of menopause (Carr, 2003) and disease-associated ERα polymorphisms (Ghattas et al, 2013; Okura et al, 2003). …”

Section: Discussionmentioning

confidence: 99%

An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females

et al. 2015

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Estrogen-receptor alpha (ERα) neurons in the ventrolateral region of the ventromedial hypothalamus (VMHVL) control an array of sex-specific responses to maximize reproductive success. In females, these VMHVL neurons are believed to coordinate metabolism and reproduction. However, it remains unknown whether specific neuronal populations control distinct components of this physiological repertoire. Here, we identify a subset of ERα VMHVL neurons that promotes hormone-dependent female locomotion. Activating Nkx2-1-expressing VMHVL neurons via pharmacogenetics elicits a female-specific burst of spontaneous movement, which requires ERα and Tac1 signaling. Disrupting development of Nkx2-1+ VMHVL neurons results in female-specific obesity, inactivity, and loss of VMHVL neurons co-expressing ERα and Tac1. Unexpectedly, two responses controlled by ERα neurons, fertility and brown adipose tissue thermogenesis, are unaffected. We conclude that a dedicated subset of VMHVL neurons marked by ERα, NKX2-1, and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses.

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Section: Discussionmentioning

confidence: 99%

An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females

et al. 2015

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“…After screening titles and abstracts, 33 articles with full-text were retrieved for eligibility. At last, 11 studies were in accordance with the inclusive criteria [16][17][18][19][20][21][22][23][24][25][26]. The detailed process of study selection is presented in ▶ Fig.…”

Section: Literature Research and Study Characteristicsmentioning

confidence: 99%

“…The study population were Caucasian (five studies) and Chinese (three studies), as well as from Egypt, Iran, India, Hungary, and China. Three studies include 395 people with MetS and 687 controls have researched the associations of both PvuII and XbaI polymorphisms with MetS [24][25][26], and all of them based on the Caucasians. All studies were published from 2001 to 2015.…”

Section: Literature Research and Study Characteristicsmentioning

confidence: 99%

Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type 2 Diabetes Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis

et al. 2018

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The associations between PvuII (T>C) and XbaI (A>G) polymorphisms of estrogen receptor alpha (ESR1) gene with type 2 diabetes mellitus (T2DM) or metabolic syndrome (MetS) are reported in many studies, but the results are inconsistent. This present work aims to assess the associations by performing a comprehensive meta-analysis. Relevant studies were searched through several databases. The pooled odd ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the associations of PvuII and XbaI polymorphisms with the risk of T2DM and MetS by using the STATA 14.0 software. Eight studies for T2DM and three articles about MetS were included in this meta-analysis. The overall results indicated that PvuII, rather than XbaI polymorphism, was associated with T2DM (regressive model: OR=0.673, 95% CI=0.550 to 0.823, p<0.001, p<0.003). The subgroup analysis based on race revealed an association of PvuII polymorphism with the decreased T2DM risk in Chinese population and a relationship between XbaI polymorphism and the reduced T2DM susceptibility in Caucasians. The difference of country may be one source of the heterogeneity for PvuII polymorphism and T2DM. However, neither PvuII nor XbaI polymorphism was related to the risk of MetS. The C allele of PvuII polymorphism presents a protective role in T2DM risk, especially in Chinese people. The G allele of XbaI polymorphism is related to a reduced risk for T2DM in Caucasian population. Nevertheless, neither of PvuII nor XbaI polymorphism is associated with MetS risk.

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“…Nevertheless, there are many studies confirming that several candidate gene polymorphisms are associated with a risk of MetS occurrence. All data on this are shown in Table 1 [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Heritability As a Metabolic Syndrome Risk Factormentioning

confidence: 99%

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

Suliga¹,

Wawszczak²,

Głuszek³

2018

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Metabolic syndrome (MetS) is defined as multiple risk factors including abdominal obesity, dyslipidaemia, abnormal glycaemia, and elevated blood pressure. The incidence of MetS and pathophysiological mechanisms underlying its development are still not fully understood. It is thought that the occurrence of MetS arises from the complex relationship between genetic and environmental factors. The aim of the study was to overview and summarise current knowledge regarding genetic determinants of MetS. Also analysed were the relationship between polymorphisms of the genes encoding selected adipokines (vaspin, chemerin, omentin) and the risk of MetS, as well as other metabolic disorders. The precise determination of MetS genotype is difficult because metabolic syndrome occurrence is a combination of multiple risk factors. A thorough understanding of pathomechanisms of MetS, involving selected adipokines, may in the future allow the use of these adipokines as potential biomarkers of metabolic disorder risk.

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Association of estrogen receptor alpha gene polymorphisms with metabolic syndrome in Egyptian women

Cited by 18 publications

References 27 publications

An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females

An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females

Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type 2 Diabetes Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

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