Association of Erythrocytes Sedimentation Rate and Platelets Indices in Diabetes in the Elderly

Abstract

Recent research indicates that inflammation can contribute to the etiology of diabetes which is characterized by hyperglycemia and abnormalities in insulin secretion and/or activity. Erythrocyte sedimentation rate (ESR) is the most often utilized laboratory test for detecting systemic inflammation among all plasma inflammatory indicators. Patients with diabetes have reportedly shown altered platelets, due to "prothrombotic condition" with increased platelet reactivity leading to vascular problems. The objective of the study was to relate platelet indices and erythrocyte sedimentation rates with Diabetes. The morphology, metabolism, and function of erythrocytes are invariably subject to a number of alterations when there is persistent hyperglycemia. Few prospective studies have looked at this issue, hence, the investigation of the link between Erythrocytes Sedimentation Rate and Platelets indices in Diabetes in a private hospital in Port Harcourt (Port Harcourt, the capital of Rivers State is the major city, situated by the Bonny River in Southern Nigeria), The study had 100 subjects who gave their consent and were chosen from among others for this cross-sectional study. Fifty patients were confirmed diabetes (21 men and 29 women; mean age: 60.1±5.02 years) and 50 control subjects without diabetes (20 men and 30 women; mean age: 58.08±5.67 years). Aseptic blood collection techniques were used to obtain blood samples from the diabetic and control groups into EDTA vials. The Sysmex XE-2100 Haematology Automated Analyzer was used to estimate platelet indices, and the Western green method was used to calculate ESR. Using the Excel Data Analysis Tool pack, the estimated values of the parameters were statistically evaluated. Both the control and diabetes groups, displayed a statistically significant difference in the mean values of ESR hence the level in the diabetic group showed greater mean values when compared to the control group values 37.42±20.55 mm/hr and 29.78±13.26 mm/hr respectively at (P=0.029). Comparing the means of the platelet indices between the two groups at a significance level of (P=0.674), there was no discernible change. The clinical diagnostic utility of ESR as a helpful indicator for following diabetic patients' progress strongly correlates with the frequency and intensity of inflammation in diabetes. It was concluded that inflammation plays a role in the development of diabetes is constantly supported by this study.