Association of ERCC gene polymorphism with osteosarcoma risk

Abstract

Background: The relationship between ERCC gene polymorphism and osteosarcoma risk / overall survival of osteosarco- ma is still conflicting, and this meta-analysis was performed to assess these associations.
 Material and methods: The association studies were identified from PubMed, and eligible reports were included and cal- culated using meta-analysis method.
 Results: Four studies were included for the association of ERCC gene polymorphism with osteosarcoma risk, and nine studies were recruited into this meta-analysis for the relationship between ERCC gene polymorphism and overall survival of osteosarcoma. The meta-analysis indicated that ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (A>G) gene polymorphism, ERCC2 rs13181 (Lys751Gln) gene pol- ymorphism were not associated with osteosarcoma risk. ERCC1 rs2298881 (C>A) gene polymorphism, ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (Asp312Asn) gene polymorphism were not associated with overall survival of osteosarcoma. Interestingly, ERCC2 rs13181 A allele and GG genotype were associated with overall survival of osteosarcoma, but AA genotype not (A allele: OR = 0.78, 95% CI: 0.65- 0.93, P = 0.007; GG genotype: OR = 1.32, 95% CI: 1.05-1.65, P = 0.02; AA genotype: OR = 0.69, 95% CI: 0.45-1.04, P = 0.08).
 Conclusion: ERCC2 rs13181 A allele and GG genotype were associated with overall survival of osteosarcoma.
 Keywords: Osteosarcoma; overall survival of osteosarcoma; ERCC; gene polymorphism; meta-analysis.

Editor’s choice: this December 2020

“…Even during this Covid-19 pandemic, NCDs are forever with thus: cardio-vascular disease nursing care, 21 hypertention, 22 HIV-exposed infants 23 , ECG abnormalities in HIV, 24 left ventricular hypertrophy, 25 epicardial fat, 26 aerobic exercise, 27 insulin resistance, 28 asthma, 29 COPD and sleep, 30 e cigarettes, 31 non- alcoholic liver disease, 32 home care, 33 Bilateral paediatric surgery, 34 self-harm, 35 MRI, 36 osteosarcoma risk, 37 thyroid 38 and gastric esophageal cancer; 39 fibromatosis, 40 prostate cancer, 41 neuro-endocrine tumour, 42 polycystic ovary and vitamin D deficiency, 43 micro RNAs and disease: 44 all will hopefully make us appreciate the burden and effect of this scourge on our people.…”

ERCC3 serves as a prognostic biomarker for hepatocellular carcinoma and positively regulates cell proliferation and migration

“…The ERCC3 gene is an essential component of NER, which is involved in the human DNA repair disorders of chromodermatosis pilaris [18], Cockayne's syndrome, and hairy sulfur dystrophy [19]. Genetic variants in ERCC3 may induce ovarian [14], breast [20], osteosarcoma [21], and pancreatic cancers [9].…”