Association of Epstein-Barr virus infection with systemic lupus erythematosus in Taiwan

Abstract

An association between Epstein-Barr virus (EBV) infection and systemic lupus erythematosus (SLE) has been suggested from previous serologic evidence. Since most adults in Taiwan are EBV-infected, seroepidemiologic studies based on standard assays for EBV are unlikely to dissociate SLE patients and control groups. We reexamine this question by using novel methodologies in which IgA anti-EBV-coded nuclear antigens-1 (EBNA-1) and IgG anti-EBV DNase antibodies were analysed by ELISA, and EBV viral loads were detected by real-time quantitative PCR for 93 adult SLE patients and 370 age-, sex- and living place-matched healthy controls in Taiwan. The specificities of antibodies for extractible nuclear antigens were determined by Western blot. Our results show that IgA anti-EBV EBNA1 antibodies were detectable in 31.2% SLE patients but only in 4.1% of controls (odds ratio [OR] = 10.72, 95% confidence interval [CI] = 5.19-22.35; P < 10(-7)), IgG anti-EBV DNase antibodies were detected in 53.8% SLE patients but only in 12.2% controls (OR = 8.40, 95% CI = 4.87-14.51; P < 10(-7)). EBV DNA was amplifiable from the sera of 41.9% SLE patients but from only 3.24% controls (P < 0.05). A significant association of IgG anti-EBV DNase antibodies with anti-Sm/RNP antibodies was observed (P < 0.005). The higher seroreactivity and higher copy numbers of EBV genome indicated association of EBV infection with SLE in Taiwan.

Avaliação diagnóstica das infecções por vírus Epstein-Barr, parvovírus B19 e vírus linfotrópico de células T humanas em pacientes portadores de lúpus eritematoso sistêmico em hospital de referência do Estado do Pará, Brasil

“…Estudos apontam para um alto percentual de positividade para EBV em pacientes com LES por PCR, variando de 41,9% até 98,5% 56,57,58,59 . No entanto, a maioria utiliza amostras celulares, como sangue total e células mononucleares do sangue periférico.…”

Systemic Lupus Erythematosus and Opportunistic Infections: Prevalence, Clinical Features

“…Таким образом, одной из основных проблем терапии СКВ является сопутствующая вирусная инфекция, кото-рая не только провоцирует отмену иммуносупрессивной терапии, но и активирует и маскирует основное заболева-ние [1,3,6,11,12].…”

“…Из 67 пациентов только у 18 (26,8%) на фоне базисной терапии не было вирусно-бактериальных осложнений. Учитывая высокую частоту HV-инфекции в популяции, мы изучали этот тип вирусной инфекции при СКВ на фоне иммуносупрессивной терапии [1,[3][4][5]12].…”

“…Выявленная нами частота инфекционных осложений при СКВ (73,1%) совпадает с данными других авторов [1,2,4,15,19].…”

“…5). Нес-мотря на, казалось бы, одинаковые клинические прояв-ления ЦМВ-и ВЭБ-инфекции, можно заметить харак-терные для того или иного типа вируса особенности, ко-торые были типичны и для СКВ [1,3,6,7,12,19]. Одна-ко у больных СКВ с коморбидной вирусной инфекцией терапия БПВП была малоэффективна.…”