Association of Epicardial Fat with Diastolic and Vascular Functions in Children with Type 1 Diabetes

Ahmad, Faisal‐Alkhateeb; Metwalley, Kotb Abbass; Mohamad, Ismail Lotfy

doi:10.1007/s00246-021-02811-x

Cited by 2 publications

(1 citation statement)

References 66 publications

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“…Echocardiography revealed a significant increase in epicardial fat thickness, left atrial diameter and % FS in patients compared to healthy children (Table 2). Previous studies have shown an increase in epicardial fat in children with type 1 diabetes mellitus with no obesity or symptoms of cardiac affection, similar to our patients [14,15]. As epicardial fat has been shown to be a form of visceral adipose tissue, these authors suggested it to be a metabolic and cardiovascular risk factor.…”

Section: Cardiac Dysfunction Is a Common Cause Of Morbidity And Morta...supporting

confidence: 88%

Role of epicardial fat thickness and irisin levels in early prediction of cardiac dysfunction in children and adolescents with type 1 diabetes mellitus

Abd ElBaky,

Ismail,

AbdelRahman

et al. 2023

polp

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Introduction: to assess the role of epicardial fat thickness and irisin in early prediction of cardiac dysfunction in children and adolescents with type 1 diabetes mellitus and correlate them with echocardiographic parameters and lipid profile. Material and methods: Sixty-three type 1 diabetic children and adolescents were recruited from the Pediatric Diabetic Clinic, National Research Centre. Thirty-four healthy children, matched for age and sex, served as controls. All patients were insulin dependent with at least 3-year duration of the disease since diagnosis. Venous blood was withdrawn under complete aseptic precautions from fasting subjects; sera were collected for evaluation of glycated haemoglobin (HbA 1C ), lipid profile and irisin levels. Two-dimensional echocardiography was performed for measurement of interventricular septal thickness in diastole, left atrial diameter (LAD), aortic root diameter, mitral E and A wave, left ventricular internal dimension in diastole, percent fractional shortening (FS%), percent ejection fraction, left ventricular mass, and epicardial fat thickness. Patients were further divided into two groups according to their glycaemic control (< 7.00, ≥ 7.0) for comparison of echocardiographic parameters and irisin. Results: Echocardiographic study revealed a statistically significant increase in LAD, FS%, and epicardial fat thickness in patients compared to controls (p = 0.000, 0.014, and 0.000 respectively). Triglyceride and irisin levels were significantly increased in patients compared to controls (p = 0.012, 0.015 respectively). Epicardial fat thickness positively correlated with left atrial diameter (p = 0.009) and left ventricular mass (p = 0.000). Irisin was positively correlated with E/A ratio (p = 0.05). Conclusions:The findings of the present study probably indicate the beginning of a state of metabolically induced diastolic dysfunction. Echocardiography should be performed in type 1 diabetic patients on a regular basis for early detection of subclinical cardiac dysfunction.

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Section: Cardiac Dysfunction Is a Common Cause Of Morbidity And Morta...supporting

confidence: 88%

Role of epicardial fat thickness and irisin levels in early prediction of cardiac dysfunction in children and adolescents with type 1 diabetes mellitus

Abd ElBaky,

Ismail,

AbdelRahman

et al. 2023

polp

View full text Add to dashboard Cite

show abstract

Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes

Cielonko

Sabati

Chambers

et al. 2023

Journal of Pediatric Endocrinology and Metabolism

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Objectives Epicardial adipose tissue (EAT) thickness, a novel marker of cardiovascular disease (CVD), is increased in children with a healthy weight and type 1 diabetes (T1D). The prevalence of obesity has increased in children with T1D and may confer additional CVD risk. The purpose of this study was to examine EAT thickness in youth with and without T1D in the setting of overweight/obesity. Methods Youth with overweight/obesity and T1D (n=38) or without T1D (n=34) between the ages of 6–18 years were included in this study. Echocardiogram using spectral and color flow Doppler was used to measure EAT and cardiac function. Waist circumference, blood pressure, and HbA1c, were used to calculate estimated glucose disposal rate (eGDR) to estimate insulin resistance in children with T1D. Results EAT thickness was not significantly different in youth with T1D compared to controls (2.10 ± 0.67 mm vs. 1.90 ± 0.59 mm, p=0.19). When groups were combined, EAT significantly correlated with age (r=0.449, p≤0.001), BMI (r=0.538, p≤0.001), waist circumference (r=0.552, p≤0.001), systolic BP (r=0.247, p=0.036), myocardial performance index (r=−0.287, p=0.015), ejection fraction (r=−0.442, p≤0.001), and cardiac output index (r=−0.306, p=0.009). In the group with T1D, diastolic BP (r=0.39, p=0.02) and eGDR (r=−0.48, p=0.002) correlated with EAT. Conclusions EAT was associated with measures of adiposity and insulin resistance but does not differ by diabetes status among youth with overweight/obesity. These findings suggest that adiposity rather than glycemia is the main driver of EAT thickness among youth with T1D.

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Association of Epicardial Fat with Diastolic and Vascular Functions in Children with Type 1 Diabetes

Cited by 2 publications

References 66 publications

Role of epicardial fat thickness and irisin levels in early prediction of cardiac dysfunction in children and adolescents with type 1 diabetes mellitus

Role of epicardial fat thickness and irisin levels in early prediction of cardiac dysfunction in children and adolescents with type 1 diabetes mellitus

Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes

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