Association of epicardial fat thickness with TIMI risk score in NSTEMI/USAP patients

Abstract

In conclusion, EAT thickness is independently associated with TIMI risk score and may be an emerging risk factor for adverse events in NSTEMI/USAP patients.

Original research. The Assessment of Epicardial Adipose Tissue in Acute Coronary Syndrome Patients. A Systematic Review

“…[38][39][40][41][42][43][44][45] Table 1 presents a summary of the included manuscripts. All systematized manuscripts contain a concise and clear portrayal of the inclusion and exclusion criteria and the method for assessing EAT, either through cardiac CT or TTE (Table 1).…”

“…38,[43][44][45] One study 43 found a significant association between EAT and GRACE scores (p <0.001), though this was not corroborated by other studies. 38 The angiographic SYNTAX score for coronary lesion severity and the clinical TIMI risk score for adverse coronary events were also found to be significantly linked with EAT.…”

“…[38][39][40][41][43][44][45] Zencirci et al (2014) hypothesized that there is an inverse association between the EAT and the STsegment resolution following primary PCI for acute STE-MI. 45 Other studied risk scores are the SYNTAX score for coronary atherosclerosis severity, the GRACE and TIMI risk scores for survival following an acute cardiac event,…”

“…38 The angiographic SYNTAX score for coronary lesion severity and the clinical TIMI risk score for adverse coronary events were also found to be significantly linked with EAT. 38,40,44 Being associated with ACS severity and risk prediction scores and connected with markers that express an increased patient vulnerability for acute coronary syndromes, at the same time being proven as an independent CAD, 53 EAT qualifies as a candidate for inclusion in current ACS risk scores.…”

Clinical importance of epicardial adipose tissue

“…Epicardial adipose tissue correlated with the degree of coronary atheromatosis, suggesting that its excessive accumulation might contribute to the development of acute coronary syndrome and coronary total occlusions [52]. In another study, EAT thickness was independently associated with the Thrombolysis in Myocardial Infarction (TIMI) risk score in patients with non-ST-elevation myocardial infarction (NSTEMI) and unstable angina pectoris [53]. In patients with the metabolic syndrome, increased EAT was associated with impaired coronary flow reserve [54].…”