Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease

Liu, Zihou; Wang, Shunjun; Wang, Yongqiang; Zhou, Ningbo; Shu, Ji; Stamm, Christof; Jiang, Meng; Luo, Fanyan

doi:10.1016/j.atherosclerosis.2019.01.033

Cited by 61 publications

(87 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…as a risk marker [1]. High levels of epicardial adipose tissue have been associated with incident cardiovascular disease and mortality in persons (particularly men) with type 2 diabetes in our previous study [2] and was associated with increased risk of coronary artery disease in persons with a high risk of cardiovascular disease, of whom 45% had type 2 diabetes [3]. An increased epicardial adipose tissue volume has also been demonstrated to be an important determinant of atrial fibrillation recurrence following electrical cardioversion or catheter ablation [4] and to correlate with ventricular tachycardia recurrence after catheter ablation in persons undergoing ventricular tachycardia ablation [5].…”

mentioning

confidence: 80%

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

Zobel

Christensen

Winther

et al. 2020

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background: Cardiac adipose tissue may have local paracrine effects on epicardial arteries and the underlying myocardium, promoting calcification and affecting myocardial microcirculation. We explored whether the total amount of cardiac adipose tissue was associated with coronary artery calcium score (CAC) and myocardial flow reserve in persons with type 1 or type 2 diabetes and healthy controls. Methods:We studied three groups: (1) 30 controls, (2) 60 persons with type 1 diabetes and (3) 60 persons with type 2 diabetes. The three groups were matched for sex and age. The three groups derived from retrospective analysis of two clinical studies. All underwent cardiac 82 Rb positron emission tomography/computed tomography (PET/CT) scanning. Cardiac adipose tissue volume (the sum of epicardial and pericardial fat), CAC, and myocardial flow reserve (ratio of pharmacological stress flow and rest flow) were evaluated using semiautomatic software. We applied linear regression to assess the association between cardiac adipose tissue, CAC and myocardial flow reserve.

show abstract

mentioning

confidence: 80%

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

Zobel

Christensen

Winther

et al. 2020

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…Известно, что объем ЭЖТ коррелирует с количеством интраабдоминального жира и взаимосвязан с факторами риска развития ССО, такими как АГ, атерогенная дислипидемия, инсулинорезистентность, гиперлептинемия, повышение уровней С-реактивного белка и фибриногена [5,6,8,10,15]. Результаты более ранних исследований показали, что количество ЭЖТ у больных ИБС и метаболическим синдромом также увеличивается с возрастом.…”

Section: Discussionunclassified

“…Некоторые авторы приводят значение 7 мм, при котором появляются признаки субклинического атеросклероза. Другие данные свидетельствуют о толщине слоя ЭЖТ более 9 мм, при которой с высокой вероятностью диагностируется резистентность к инсулину и повышен риск острых сердечнососудистых событий [5,6,8,28].…”

Section: Discussionunclassified

“…В связи с этим использование новых маркеров риска развития ССЗ позволит более точно определить вероятность возникновения, тяжелого течения ИБС и осложнений этого заболевания. Одним из таких независимых факторов риска может стать избыточное количество эпикардиальной жировой ткани (ЭЖТ) [5].…”

unclassified

See 1 more Smart Citation

Prognostic value of epicardial fat thickness in coronary heart disease patients after myocardial revascularization

2020

View full text Add to dashboard Cite

Objective To study the role of epicardial adipose tissue (EAT) in determination of risk for adverse course of ischemic heart disease (IHD) in patients after myocardial revascularization.Materials and Methods This study included 217 subjects, 182 IHD patients and 35 evaluated individuals without IHD. Percutaneous coronary intervention (PCI) was performed for 104 patients and coronary bypass (CB) was performed for 78 patients. Also echocardiography (EchoCG) and cardiac computed tomography were performed.Results In IHD patients, EAT volume and thickness were greater than in evaluated subjects without IHD. The composite endpoint (CEP) was observed after PCI more frequently than after CB. In IHD patients with an EAT thickness of 8.5 to 10.2 mm measured with EchoCG in the atrioventricular groove, the risk of CEP was 4.3 times higher after myocardial revascularization than with thicker or thinner EAT regardless of the revascularization method.Conclusion An EAT thickness of 8.5 to 10.2 mm in the atrioventricular groove as measured with EchoCG was associated with a risk of adverse IHD course in patients who have underwent myocardial revascularization.

show abstract

“…So far, clinical studies have shown that EAT expansion is an independent CAD risk factor (Herrington et al, 2016;Mahabadi et al, 2013;Nakanishi et al, 2014;Liu et al, 2019). Some EAT functions were reported in cell and animal studies.…”

Section: Introductionmentioning

confidence: 99%

Identification of key genes and pathways affected in epicardial adipose tissue from patients with coronary artery disease by integrated bioinformatics analysis

Tan

Wang

et al. 2020

PeerJ

View full text Add to dashboard Cite

Background Coronary artery disease (CAD) is a common disease with high cost and mortality. Here, we studied the differentially expressed genes (DEGs) between epicardial adipose tissue (EAT) and subcutaneous adipose tissue (SAT) from patients with CAD to explore the possible pathways and mechanisms through which EAT participates in the CAD pathological process. Methods Microarray data for EAT and SAT were obtained from the Gene Expression Omnibus database, including three separate expression datasets: GSE24425, GSE64554 and GSE120774. The DEGs between EAT samples and SAT control samples were screened out using the limma package in the R language. Next, we conducted bioinformatic analysis of gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways to discover the enriched gene sets and pathways associated with DEGs. Simultaneously, gene set enrichment analysis was carried out to discover enriched gene functions and pathways from all expression data rather than DEGs. The PPI network was constructed to reveal the possible protein interactions consistent with CAD. Mcode and Cytohubba in Cytoscape revealed the possible key CAD genes. In the next step, the corresponding predicted microRNAs (miRNAs) were analysed using miRNA Data Integration Portal. RT-PCR was used to validate the bioinformatic results. Results The three datasets had a total of 89 DEGs (FC log2 > 1 and P value < 0.05). By comparing EAT and SAT, ten common key genes (HOXA5, HOXB5, HOXC6, HOXC8, HOXB7, COL1A1, CCND1, CCL2, HP and TWIST1) were identified. In enrichment analysis, pro-inflammatory and immunological genes and pathways were up-regulated. This could help elucidate the molecular expression mechanism underlying the involvement of EAT in CAD development. Several miRNAs were predicted to regulate these DEGs. In particular, hsa-miR-196a-5p and hsa-miR-196b-5p may be more reliably associated with CAD. Finally, RT-PCR validated the significant difference of OXA5, HOXC6, HOXC8, HOXB7, COL1A1, CCL2 between EAT and SAT (P value < 0.05). Conclusions Between EAT and SAT in CAD patients, a total of 89 DEGs, and 10 key genes, including HOXA5, HOXB5, HOXC6, HOXC8, HOXB7, COL1A1, CCND1, CCL2, HP and TWIST1, and miRNAs hsa-miR-196a-5p and hsa-miR-196b-5p were predicted to play essential roles in CAD pathogenesis. Pro-inflammatory and immunological pathways could act as key EAT regulators by participating in the CAD pathological process.

show abstract

Association of epicardial adipose tissue attenuation with coronary atherosclerosis in patients with a high risk of coronary artery disease

Cited by 61 publications

References 36 publications

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

Prognostic value of epicardial fat thickness in coronary heart disease patients after myocardial revascularization

Identification of key genes and pathways affected in epicardial adipose tissue from patients with coronary artery disease by integrated bioinformatics analysis

Contact Info

Product

Resources

About