Association of eosinophilic esophagitis and food pollen allergy syndrome

Mahdavinia, Mahboobeh; Bishehsari, Faraz; Hayat, Waqas; Elhassan, Ahmed; Tobin, Mary C.; Ditto, Anne Marie

doi:10.1016/j.anai.2016.10.012

Cited by 25 publications

(10 citation statements)

References 10 publications

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“…Another interesting association, although not common, is the exaggeration or development of EoE as related to pollen exposure [14]. Our subject was allergic to pollen, but did not demonstrate oral allergy syndrome symptoms.…”

Section: Discussionmentioning

confidence: 98%

Do Pinworms Cause Eosinophilic Esophagitis?

Hopp¹,

Lewis²,

Kunnath³

2017

J Allergy Ther

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Eosinophils are found in the gastrointestinal tract with the exception of the esophagus. Eosinophilic esophagitis (EE) clinically results in heartburn, abdominal pain and vomiting, and most children with EE are atopic. Diagnosis is supported by esophageal biopsy findings of >15 eosinophil's/hpf. Enterobius vermicularis infection is characteristically mild. However, there are case reports of eosinophilic ileocolitis, gastroenteritis and appendicitis secondary to pinworm infestation, but no case reports of EE associated with pinworm infestation have been reported.

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Section: Discussionmentioning

confidence: 98%

Do Pinworms Cause Eosinophilic Esophagitis?

Hopp¹,

Lewis²,

Kunnath³

2017

J Allergy Ther

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“…An association between PFAS and EoE has been described in adults [7,11]. Mahdavinia et al [7] showed that adults with EoE and AR had a higher prevalence of PFAS compared to AR patients without EoE (50.9% vs. 10.2%, p < 0.001). Two possible mechanisms were proposed for this association.…”

Section: Discussionmentioning

confidence: 99%

“…However, data on the correlation between the 2 diseases is insufficient. A previous report suggested that an association between PFAS and EoE might be present only in adults [ 7 ]. We herein report the case of an 8-year-old boy with EoE and PFAS.…”

Section: Introductionmentioning

confidence: 99%

Pediatric patient with eosinophilic esophagitis and pollen-food allergy syndrome

Irahara

Nomura

Takeuchi

et al. 2020

Asia Pacific Allergy

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The incidence of eosinophilic esophagitis (EoE) and pollen-food allergy syndrome (PFAS) is increasing worldwide, and coexistence of these 2 diseases has been reported in adults. In children, however, these conditions have not been reported as comorbidities probably because sensitization to aeroallergens occurs at an older age. We report the case of a boy with EoE and PFAS. He had had intermittent vomiting since 2 years of age. At 7 years of age, he experienced an episode of itchiness of the lips and throat for the first time, followed by vomiting, immediately after ingesting some raw fruits. We diagnosed PFAS based on the skin prick test at 8 years of age and diagnosed EoE by esophagogastroduodenoscopy 11 months after the diagnose of PFAS. His digestive symptoms did not disappear despite eliminating the fruits responsible for PFAS, but esomeprazole improved his symptoms. The incidence of EoE and PFAS as comorbidities in children might increase in the future.

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“…Even in the absence of nasal symptoms, subclinical untreated inflammation from pollen sensitivities, could lead to impaired esophageal barrier which then lead to more food antigen susceptibility. 17 The most common food allergens associated with EoE are cow's milk, wheat, egg, soy, nuts and seafood. Initial reports showed approximately 80% improvement with this six-food elimination diet, but later reports on four-food-group-elimination diet (milk, wheat, egg and soy) showed promising results especially when coupled with topical steroids, either fluticasone inhalerswallow technique or budesonide slurry.…”

Section: Eosinophilic Esophagitis (Eoe)mentioning

confidence: 99%

Updates on Food Allergy, Increasingly Prevalent Challenge

Tanus¹,

Wangko²

2018

JBM

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Abstrak: Prevalensi alergi makanan makin meningkat di seluruh dunia dan mengenai semua usia. Keparahan dan kompleksitas penyakit juga meningkat terlebih pada populasi anak. Terdapat beberapa jenis reaksi alergi yang dibahas: immunoglobulin E (IgE) mediated allergies and anaphylaxis, food triggered atopic dermatitis, eosinophilic esophagitis, dan non IgE mediated gastrointestinal food allergic disorders seperti food protein induced enterocolitis syndrome (FPIEs). Tes alergi, baik melalui kulit maupun IgE yang telah dikerjakan sekian lama masih dibebani dengan hasil positif palsu dan negatif palsu yang bermakna dengan manfaat terbatas pada beberapa alergi makanan. Selain menghindari, tidak terdapat terapi yang ampuh untuk alergi makanan. Berbagai imunoterapi telah dipelajari melalui jalur, subkutan, epikutan, oral dan sublingual yang hanya menghasilkan desensitisasi sementara dan dibebani dengan berbagai isu mengenai keamanannya. Agen biologik yang menghambat sitokin/interleukin (IL) dan molekul pada reaksi alergi makanan tampaknya merupakan pilihan yang menjanjikan. Anti IgE telah dipergunakan pada asma dan urtikaria kronis. Anti IL-4 dan IL-13 yang menghambat produksi IgE diindikasikan untuk dermatitis atopik. Anti eosinofil anti IL-5 berhasil menurunkan eksaserbasi asma. Berbagai agen biologik telah dipelajari untuk berbagai kondisi alergik dan imunologik, tetapi efektivitas dan kepraktisan terapi yang mahal ini untuk alergi makanan masih menjadi tanda tanya.Kata kunci: alergi makanan, reaksi alergi, terapi alergi makananAbstract: Food allergies have been increasing in prevalence for years affecting all ages. Disease severity and complexity have also increased, especially in the pediatric population. There are several types of reactions including: immunoglobulin-E (IgE) mediated allergies and anaphylaxis, food-triggered atopic dermatitis, eosinophilic esophagitis, and non IgE mediated gastrointestinal food allergic disorders such as FPIEs. Though allergy testing has been around for years, both skin and IgE testing are burdened by significant false positives and negatives, and are only useful in some food allergies. Avoidance is the sole therapy for food allergy. A variety of immunotherapies have been studied; subcutaneous, epicutaneous, oral, and sublingual. At best they only produce a temporary state of desensitization and have many safety issues. Examples of biologicals which block critical cytokines/interleukins (IL) in allergic conditions are Anti IgE, anti IL-4 and IL-13, and Anti eosinophils, Anti IL-5. Other biologicals are being studied for allergic conditions, but whether these expensive future treatments will be proven effective and practical in food allergy is unknown.Keywords: food allergy, allergic reaction, food allergy therapy

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Association of eosinophilic esophagitis and food pollen allergy syndrome

Cited by 25 publications

References 10 publications

Do Pinworms Cause Eosinophilic Esophagitis?

Do Pinworms Cause Eosinophilic Esophagitis?

Pediatric patient with eosinophilic esophagitis and pollen-food allergy syndrome

Updates on Food Allergy, Increasingly Prevalent Challenge

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