Association of Endothelial Nitric Oxide Synthase 894G &gt; T Polymorphism with Preeclampsia Risk: A Systematic Review and Meta-Analysis based on 35 Studies

Abbasi, Hajar; Dastgheib, Seyed Alireza; Hadadan, Amaneh; Karimi-Zarchi, Mojgan; Javaheri, Atiyeh; Meibodi, Bahare; Zanbagh, Leila; Tabatabaei, Razieh Sadat; Neámatzadeh, Hossein

doi:10.1080/15513815.2019.1710880

Cited by 25 publications

(14 citation statements)

References 56 publications

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“…29 A systematic review, examining the association between the endothelial nitric oxide synthase polymorphism and preeclampsia risk stratified by ethnicity, identified a higher risk of preeclampsia in the white or mixed populations with the 894 G>T polymorphism, but not in those of Asian or African descent. 30 Another systematic review reported that IL10 −1082 G>A polymorphism significantly increased the risk of preeclampsia in Asian women, but not in White population. 31 Besides impaired placentation, immunological factors, endothelial function, and inflammation have all been identified as contributors to the pathophysiology of preeclampsia.…”

Section: Interpretation Of the Resultsmentioning

confidence: 99%

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

et al. 2021

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ObjectivePrevious studies suggested mean arterial pressure (MAP) had moderate predictive values in the first and second trimesters for the prediction of preeclampsia. However, the performance of MAP in Asian women is still unclear. The objective of this study was to examine the predictive values of MAP in Asian population throughout gestation, and to compare the performance of MAP, angiogenic factors and uterine artery Doppler in the prediction of preeclampsia.DesignA prospective cohort study.SettingKK Women’s and Children’s Hospital, Singapore.ParticipantsA total of 926 women with singleton pregnancy less than 14 weeks of gestation were included in the prospective Neonatal and Obstetrics Risks Assessment cohort between September 2010 and October 2014. Maternal blood pressure levels, uterine artery pulsatility index (UtA-PI), serum soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio were measured at 11–14, 18–22, 28–32 and 34 weeks onward, respectively.Primary and secondary outcomesPreeclampsia was the main pregnancy outcome.ResultsA total of 20 women developed preeclampsia, who had significantly lower levels of PlGF, higher levels of sFlt-1/PlGF ratio and MAP throughout pregnancy than women without preeclampsia. Compared with angiogenic factors and UtA-PI, MAP had significantly higher area under the receiver operating characteristic curves (AUCs) for predicting preeclampsia and term preeclampsia throughout gestation. For predicting preeclampsia, MAP had AUCs of 0.86 (95% CI 0.78 to 0.95), 0.87 (95% CI 0.80 to 0.95) and 0.91 (95% CI 0.85 to 0.98) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting term preeclampsia, MAP yielded AUCs of 0.87 (95% CI 0.75 to 0.99), 0.87 (95% CI 0.76 to 0.98) and 0.90 (95% CI 0.80 to 0.99) at 11–14, 18–22 and 28–32 weeks, respectively. For predicting preterm preeclampsia, the performance of MAP and PlGF was similar.ConclusionMAP is a good predictor for preeclampsia, especially term preeclampsia, in Asian women.

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Section: Interpretation Of the Resultsmentioning

confidence: 99%

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

et al. 2021

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“…81e83 In a systematic review of 35 studies looking at the endothelial nitric oxide synthase polymorphism and preeclampsia risk stratified by ethnicity, a higher risk of preeclampsia was observed in the White or mixed-race populations with the 894 guanine>thymine polymorphism but not in those of Asian or African descent. 81 Another systematic review and metaanalysis based on 21 studies investigated the role of interleukin-10 (IL-10) polymorphisms and preeclampsia risk. IL-10e1082 guanine>adenine polymorphism stratified by ethnicity found a markedly increased risk of developing preeclampsia in Asian and mixed-race populations but not in White populations.…”

Section: Expert Reviewmentioning

confidence: 99%

Does race or ethnicity play a role in the origin, pathophysiology, and outcomes of preeclampsia? An expert review of the literature

Johnson

Louis

2022

American Journal of Obstetrics and Gynecology

121

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“…NOS3 is responsible for the generation of the vast majority of NO in the endothelium and therefore controls vascular homeostasis [ 32 ]. Polymorphisms in NOS3 gene are associated with the risks of many diseases such as preeclampsia, cerebral aneurysm, migraine, acute ischemic stroke, and coronary heart disease in specific populations [ 33 - 37 ]. NOS3 plays a significant role in maintaining pulmonary function under normal conditions.…”

Section: Discussionmentioning

confidence: 99%

Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression

Zheng

Wei

et al. 2023

Korean J Physiol Pharmacol

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This study is to determine the regulation of nitric oxide synthase 3 (NOS3) by edaravone in mice with hypoxic pulmonary hypertension (HPH). C57BL/6J mice were reared in a hypoxic chamber. HPH mice were treated with edaravone or edaravone + L-NMMA (a NOS inhibitor). Lung tissue was collected for histological assessment, apoptosis analysis, and detection of malondialdehyde, superoxide dismutase, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and NOS3. The levels of serum TNF-α and IL-6 were also measured. Immunohistochemistry was used to visualize the expression of α-smooth muscle actin (SMA) in pulmonary arterioles. Edaravone treatment improved hemodynamics, inhibited right ventricular hypertrophy, increased NOS3 expression, and reduced pathological changes, pulmonary artery wall thickness, apoptotic pulmonary cells, oxidative stress, and the expression of TNF-α, IL-6, and α-SMA in HPH mice. L-NMMA treatment counteracted the lung protective effects of edaravone. In conclusion, edaravone might reduce lung damage in HPH mice by increasing the expression of NOS3.

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Association of Endothelial Nitric Oxide Synthase 894G > T Polymorphism with Preeclampsia Risk: A Systematic Review and Meta-Analysis based on 35 Studies

Cited by 25 publications

References 56 publications

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

Mean arterial pressure for predicting preeclampsia in Asian women: a longitudinal cohort study

Does race or ethnicity play a role in the origin, pathophysiology, and outcomes of preeclampsia? An expert review of the literature

Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression

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