Association of endothelial nitric oxide synthase promoter region (T-786C) gene polymorphism with acute coronary syndrome and coronary heart disease

Çıftçı, Çavlan; Melil, Süreyya; Çebi, Y; Ersöz, Melike; Çağatay, Penbe; Kılıçgedik, M; Duman, Belgin Süsleyici

doi:10.1186/1476-511x-7-5

Cited by 26 publications

(18 citation statements)

References 32 publications

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“…TT was the genotype most frequently observed in both patients with CAD (Ciftçi et al, 2008). Similarly, Dosenko et al (2005) studying a group of patients with ACS in the Ukrainian population, found the C polymorphism of the 5'-flanking region of the eNOS gene 2.7-fold more frequently in patients with ACS than in controls.…”

Section: Discussionmentioning

confidence: 98%

Research Article Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism.

Barbosa¹,

Silva²,

Lagares³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large-and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has been shown to be a promising therapeutic agent against cardiovascular diseases. The eNOS gene assumes several important functions, including regulation of vascular tone and regional blood flow, the suppression of vascular smooth muscle cell proliferation, and modulation of leukocyte-endothelium interactions. The T786C polymorphism is an important point mutation, where thymine is changed to cytosine. T786C significantly reduces the activity of the eNOS promoter gene. Two hundred and ninety-seven peripheral blood samples were collected from patients with the previous diagnosis of atherosclerotic disease based on clinical examination and confirmed by imaging methods. Results were compared using the chisquare test and the G-test. In the present study, the TC genotype was more frequent in both case and control groups with no statistically significant difference. Comparing the relation TC/TT and CC genotypes in the case and control groups, there was no statistically significant difference. No significant difference was found when genotypes were analyzed regarding gender and smoking. Our results suggest a strong tendency of the T allele, in single or double dose, to be associated with atherosclerosis that was not confirmed by the scientific data.

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Section: Discussionmentioning

confidence: 98%

Research Article Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism.

Barbosa¹,

Silva²,

Lagares³

et al. 2017

Genet. Mol. Res.

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show abstract

“…It was demonstrated in previous studies that the T/C (-786) eNOS polymorphism is associated with diabetic nephropathy and end stage renal disease [16,36], diabetic retinopathy and diabetic macula edema [38,39], albuminuria [40], rheumatoid arthritis [41], acute coronary syndrome [42,43], coronary artery disease [44] essential and arterial hypertension [45,46], inflammation and atherosclerosis [37,47]. In our study, significant results appeared for the T/C eNOS polymorphism in the comparison with genotype's frequencies between the healthy individuals and the groups (DM, DN, NDRD respectively) of diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

et al. 2012

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A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism and the T/C (−786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes.

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“…Гіпотеза щодо впливу поліморфізму Т-786С промотора гена еNOs на перебіг і прогноз ІХС підтверджується резуль-татами досліджень китайської та європейської популяції, в яких доведено зв'язок СС генотипу з розвитком ІМ [11,12].…”

Section: таблиця 2 частоти алелів і генотипів I/d поліморфізму гена аunclassified

Poor Prognosis Predictor in Ischemic Heart Disease Patients With Confirmed Hemodynamically Significant Coronary Artery Atherosclerosis in the Dynamics of Long Observation

Yakovleva

2014

ZMJ

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It was found that adverse cardiovascular events development in patients with stable ischemic heart disease (IHD) with verifi ed coronary artery (CA) atherosclerosis is associated with the presence of arterial hypertension, type 2 diabetes mellitus, smoking, family history of CVD early onset. As well as more than one MI in anamnesis, with atherosclerotic lesions of the carotid arteries and blood vessels of the lower extremities, lesions of the three CA and diffuse type of lesion according to SCG, reduced left ventricular ejection fraction less than 45% and declining of renal function according to GFR. It was proved that the DD genotype of angiotensin-converting enzyme I/D polymorphism and the CC genotype of endothelial NO-synthase T-786S promoter polymorphism were associated with poor prognosis in patients with stable IHD.

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Association of endothelial nitric oxide synthase promoter region (T-786C) gene polymorphism with acute coronary syndrome and coronary heart disease

Cited by 26 publications

References 32 publications

Research Article Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism.

Research Article Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism.

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

Poor Prognosis Predictor in Ischemic Heart Disease Patients With Confirmed Hemodynamically Significant Coronary Artery Atherosclerosis in the Dynamics of Long Observation

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