Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients

Cao, Cheng; Hu, Jianxin; Yan, Dong; Zhan, Rui; Li, Ping; Su, Hai; Peng, Qiang; Wu, Tao Cheng; Huang, Xiao; Sun, Wen‐Hua; Wu, Qinghua; Cheng, Xiaoshu

doi:10.1093/ajh/hpv128

Cited by 13 publications

(8 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In case our hypothesis is true, the total burden of cardiometabolic disorders and the level of inflammation/malnutrition and muscle loss would be a better correlate of decreased cognitive function and the presence of a cognitive frailty phenotype than just decreased renal function. Evidence that the coexistence of kidney and heart diseases, relative to the stages of progression of these disorders, contributes to the development of malnutrition, inflammation, frailty, and cognitive impairment is scarce, however, since these disorders have only been examined separately as two independent disorders [ 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Clusters of Physical Frailty and Cognitive Impairment and Their Associated Comorbidities in Older Primary Care Patients

et al. 2021

View full text Add to dashboard Cite

(1) Objectives: We aimed to identify clusters of physical frailty and cognitive impairment in a population of older primary care patients and correlate these clusters with their associated comorbidities. (2) Methods: We used a latent class analysis (LCA) as the clustering technique to separate different stages of mild cognitive impairment (MCI) and physical frailty into clusters; the differences were assessed by using a multinomial logistic regression model. (3) Results: Four clusters (latent classes) were identified: (1) highly functional (the mean and SD of the “frailty” test 0.58 ± 0.72 and the Mini-Mental State Examination (MMSE) test 27.42 ± 1.5), (2) cognitive impairment (0.97 ± 0.78 and 21.94 ± 1.95), (3) cognitive frailty (3.48 ± 1.12 and 19.14 ± 2.30), and (4) physical frailty (3.61 ± 0.77 and 24.89 ± 1.81). (4) Discussion: The comorbidity patterns distinguishing the clusters depend on the degree of development of cardiometabolic disorders in combination with advancing age. The physical frailty phenotype is likely to exist separately from the cognitive frailty phenotype and includes common musculoskeletal diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Clusters of Physical Frailty and Cognitive Impairment and Their Associated Comorbidities in Older Primary Care Patients

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Increased filling pressure and compensatory myocardial thickening would limit LV diastolic function, which may then lead to LV diastolic stiffness and concentric LV hypertrophy [ 44 ]. In contrast, LV hypertrophy may induce greater circulatory stress resulting in impaired endothelial function, which may then cause more severe inflammation and a greater risk of endotoxemia, all of which would contribute to VC [ 42 , 45 ]. One of the major causes of cardiomegaly in ESRD patients is volume overload.…”

Section: Discussionmentioning

confidence: 99%

Aortic Arch Calcification and Cardiomegaly Are Associated with Overall and Cardiovascular Mortality in Hemodialysis Patients

Liu

Chung

et al. 2021

JPM

View full text Add to dashboard Cite

Patients with end-stage renal disease have a higher risk of cardiovascular morbidity and mortality. In this study, we investigated the predictive ability of a combination of cardiothoracic ratio (CTR) and aortic arch calcification (AoAC) for overall and cardiovascular mortality in patients receiving hemodialysis. We also evaluated the predictive power of AoAC and CTR for clinical outcomes. A total of 365 maintenance hemodialysis patients were included, and AoAC and CTR were measured using chest radiography at enrollment. We stratified the patients into four groups according to a median AoAC score of three and CTR of 50%. Multivariable Cox proportional hazards analysis was used to identify the risk factors of mortality. The predictive performance of the model for clinical outcomes was assessed using the χ2 test. Multivariable analysis showed that, compared to the AoAC < 3 and CTR < 50% group, the AoAC ≥ 3 and CTR < 50% group (hazard ratio [HR], 4.576; p < 0.001), and AoAC ≥ 3 and CTR ≥ 50% group (HR, 5.912; p < 0.001) were significantly associated with increased overall mortality. In addition, the AoAC < 3 and CTR ≥ 50% (HR, 3.806; p = 0.017), AoAC ≥ 3 and CTR < 50% (HR, 4.993; p = 0.002), and AoAC ≥ 3 and CTR ≥ 50% (HR, 8.614; p < 0.001) groups were significantly associated with increased cardiovascular mortality. Furthermore, adding AoAC and CTR to the basic model improved the predictive ability for overall and cardiovascular mortality. The patients who had a high AoAC score and cardiomegaly had the highest overall and cardiovascular mortality among the four groups. Furthermore, adding AoAC and CTR improved the predictive ability for overall and cardiovascular mortality in the hemodialysis patients.

show abstract

“…We speculate that patients with LVH may have greater circulatory stress during HD and consequently greater endotoxemia and more severe inflammation, all of which would contribute to VC, compared with those without LVH. In addition, endothelial biology is impaired in patients with LVH 30 - 32 . Given the close proximity of endothelial and smooth muscle cells in blood vessels, dysfunctional endothelial cells cause the development and progression of VC through the modulation of smooth muscle cells 33 , 34 .…”

Section: Discussionmentioning

confidence: 99%

Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts

et al. 2018

View full text Add to dashboard Cite

Background: We examined the relationship and combined effect of vascular calcification (VC) and left ventricular hypertrophy (LVH) on deaths and cardiovascular events (CVEs) in hemodialysis (HD) patients.Methods: Maintenance HD patients (n=341) were included. Echocardiography data and plain chest radiographs were used to assess LVH and aortic arch VC.Results: VC was found in 100 patients (29.3%). LVH was more prevalent in patients with VC compared with those without VC (70% vs. 50.2%, P=0.001). VC was independently associated with a 2.42-fold increased risk of LVH (95% CI, 1.26-4.65). In multivariate analysis, compared with patients with neither VC nor LVH, the coexistence of VC and LVH was independently associated with CVE (HR, 2.01; 95% CI, 1.09-3.72), whereas VC or LVH alone was not. Patients with both VC and LVH had the highest risk for a composite event of deaths or CVE (HR, 1.88; 95% CI, 1.15-3.06). Significant synergistic interaction was observed between VC and LVH (P for interaction=0.039).Conclusions: VC was independently associated with LVH. The coexistence of VC and LVH was associated with higher risk of deaths and CVEs than either factor alone. VC and LVH showed a synergistic interaction for the risk of deaths and CVEs.

show abstract

Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients

Abstract: The concurrence of endothelial and mild renal dysfunction was significantly associated with the severity of LVH in hypertensive patients.

Cited by 13 publications

References 37 publications

Clusters of Physical Frailty and Cognitive Impairment and Their Associated Comorbidities in Older Primary Care Patients

Clusters of Physical Frailty and Cognitive Impairment and Their Associated Comorbidities in Older Primary Care Patients

Aortic Arch Calcification and Cardiomegaly Are Associated with Overall and Cardiovascular Mortality in Hemodialysis Patients

Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts

Contact Info

Product

Resources

About