Association of elevated serum alanine aminotransferase with metabolic factors in obese children: sex-related analysis

Bonito, Procolo Di; Sanguigno, Eduardo; Fraia, Teresa Di; Forziato, Claudia; Boccia, Gabriella; Saitta, Francesco; Iardino, Maria Rosaria; Capaldo, Brunella

doi:10.1016/j.metabol.2008.10.010

Cited by 53 publications

(54 citation statements)

References 27 publications

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“…Regarding the gender difference in the prevalence of ALT elevation, different views have been expressed: Bonito et al 27 recommended sex-related cutoff of ALT levels for ob children (ALT430 IU l À1 for boys and 419 IU l À1 for girls).…”

Section: Discussionmentioning

confidence: 99%

Obese boys at increased risk for nonalcoholic liver disease: evaluation of 16 390 overweight or obese children and adolescents

et al. 2010

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Objective: Comorbidities of childhood obesity challenge health-care systems in Europe. Further, there is a lack of populationspecific prevalence data and diagnostic strategies available, especially for obesity-related disturbances of liver function. Therefore, the prevalence of elevated liver enzymes and their relationship to biological parameters were studied in a large pediatric obesity cohort. Methods: In 111 specialized pediatric obesity centers in Germany, Austria and Switzerland, 16 390 children and adolescents (age 12.4 ± 2.6 years, 58% boys) were categorized as overweight (body mass index (BMI) 490th percentile) and obese (497th percentile) and studied for related comorbidities, especially nonalcoholic fatty liver disease (NAFLD; as defined by aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) 450 U l À1 ). Data were collected using a standardized software program (APV) for longitudinal multicenter documentation. Pseudonymized data were transmitted for central statistical analysis. Results: In this pediatric cohort, 16% of the study population was overweight, 46% obese and 35% extremely obese (499.5th percentile extreme obesity (Xob)). NAFLD was present in 11% of the study population, but predominantly in boys (boys vs girls; 14.4:7.4%; Po0.001), in Xob (obese vs Xob; 9.5:17.0%; Po0.001) and in older age (o 12 vs X12 years; 8:12%; Po0.001; adjusted for BMI). ALT 450 U l À1 was significantly associated with fasting insulin and BMI-SDS. In multiple logistic regression models, Xob and male gender were strongly associated with NAFLD (odds ratio Xob vs normal weight ¼ 3.2; boys vs girls OR ¼ 2.3). Conclusion: In a large cohort of overweight and obese European children and adolescents, markers of nonalcoholic liver disease, especially ALT, are frequent and predicted by Xob and male gender. The results underline the epidemiological dimension of this obesity-related morbidity even in childhood. Therefore, at least ALT is recommended as a screening parameter in basic care.

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Section: Discussionmentioning

confidence: 99%

Obese boys at increased risk for nonalcoholic liver disease: evaluation of 16 390 overweight or obese children and adolescents

et al. 2010

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“…Otros autores han descrito la elevación de los triglicéridos junto con la elevación de la circunferencia abdominal 15 . Encontramos mejor relación con la obesidad cintura que con el IMC, lo cual coincide con lo descrito por González-Gil 16 .…”

Section: Discussionunclassified

“…Encontramos mejor relación con la obesidad cintura que con el IMC, lo cual coincide con lo descrito por González-Gil 16 . Adicionalmente, nuestro estudio demostró relación entre elevación de ALT y presiones arteriales sistólicas y diastólicas asociadas, a diferencia de lo reportado por Di Bonito quien sólo reporta relación con la presión arterial sistólica 15 .…”

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Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños

et al. 2012

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“…and hepatitis, while a ratio of more than 2 is present in alcoholism, hyperthyroidism, hemochromatosis, and Wilson's disease. Most alcoholic patients have elevated liver enzyme levels, however, the elevation is not as high as that in acute viral hepatitis (6).…”

Section: Introductionmentioning

confidence: 93%

Evaluation of Liver Enzyme Elevation and Its Contributing Factors in Birjand, Iran

et al. 2017

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Background and Objectives: Abnormal pattern of liver enzymes can provide valuable evidence for the diagnosis of a wide range of diseases. The aim of this study was to evaluate liver enzyme elevation and its contributing factors in Birjand, Iran. Methods: This descriptive-analytic study was conducted on 5240 residents of Birjand city, Iran. Primarily, liver enzyme test was performed for all participants and then, the test was repeated for all individuals with liver enzyme elevation (i.e. an alanine transaminase of more than 40 IU/L) at the first measurement. After that, individuals with liver enzyme elevation at both measurements were subjected to blood testing for low-density lipoprotein, high-density lipoprotein, fasting blood sugar, hepatitis B surface antigen, hepatitis C virus antibody, and total bilirubin as well as ultrasound assessment for fatty liver disease. The SPSS software (v. 16.0) was employed for data analysis.

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Association of elevated serum alanine aminotransferase with metabolic factors in obese children: sex-related analysis

Cited by 53 publications

References 27 publications

Obese boys at increased risk for nonalcoholic liver disease: evaluation of 16 390 overweight or obese children and adolescents

Obese boys at increased risk for nonalcoholic liver disease: evaluation of 16 390 overweight or obese children and adolescents

Marcadores de síndrome metabólico como predictores de elevación de alanino aminotransferasa en niños

Evaluation of Liver Enzyme Elevation and Its Contributing Factors in Birjand, Iran

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