Association of elevated fasting C-peptide level and increased intra-abdominal fat distribution with development of NIDDM in Japanese-American men

Bergstrom, Richard W.; Newell‐Morris, Laura; Leonetti, Donna L.; Shuman, William P.; Wahl, Patricia W.; Fujimoto, Wilfred Y.

doi:10.2337/diabetes.39.1.104

Cited by 110 publications

(97 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From this population, 229 Japanese-American Nisei men (American born and reared sons of immigrants from Japan) were enrolled into the study. Details pertaining to the recruitment, enrollment, characterization and generational assignment of the study group have been reported previously [11,22,23]. Briefly, the 229 men in the study group were selected from 487volunteers.…”

Section: Methodsmentioning

confidence: 99%

“…This relationship is thought to be mediated by insulin resistance [8]. Both fasting insulin and fasting C-peptide have been employed as a measure of insulin resistance [8][9][10][11]. However C-peptide is not metabolized by the liver and is therefore a more reliable index of prehepatic insulin secretion than the fasting insulin [12].…”

mentioning

confidence: 99%

“…However C-peptide is not metabolized by the liver and is therefore a more reliable index of prehepatic insulin secretion than the fasting insulin [12]. High C-peptide levels have been interpreted as representing hypersecretion of insulin as a compensatory response to insulin resistance [8,11]. Elevated C-peptide levels have been shown to precede the development of Type 2 diabetes in Japanese American men [11].…”

mentioning

confidence: 99%

“…High C-peptide levels have been interpreted as representing hypersecretion of insulin as a compensatory response to insulin resistance [8,11]. Elevated C-peptide levels have been shown to precede the development of Type 2 diabetes in Japanese American men [11]. Insulin resistance is increased in obesity and with site-specific differences in body fat deposits, which are also characteristically associated with Type 2 diabetes and coronary heart disease [13,14].…”

mentioning

confidence: 99%

See 3 more Smart Citations

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

et al. 1990

Self Cite

View full text Add to dashboard Cite

Summary. In a community-based study of second-generation Japanese-American men known to have a high prevalence of both Type 2 (non-insulin-dependent) diabetes and impaired glucose tolerance, there was a highly significant association of coronary heart disease with glucose intolerance in a study sample of 219 men. Intra-abdominal cross sectional fat area determined by computed tomography was significantly elevated in men with coronary heart disease even after adjustment for glucose intolerance and body mass index (p = 0.026). Other differences that were significantly related to coronary heart disease after adjustment for glucose intolerance were lower high density lipoprotein cholesterol levels (p = 0.001), elevated total triglyceride and very low density lipoprotein triglyceride (p < 0.001), and elevated fasting insulin and C-peptide levels p = 0.001. When these variables were tested in a stepwise multiple logistic regression model, significant independent associations with coronary heart disease were found only for total triglyceride and fasting C-peptide after adjustment for glucose tolerance status. Variables identified to be associated with coronary heart disease were interpreted as representing or manifesting an insulin resistant state. Thus, insulin resistance may be the underlying risk factor aetiologically linking glucose intolerance with coronary heart disease.

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

et al. 1990

Self Cite

View full text Add to dashboard Cite

show abstract

“…These studies have demonstrated that insulin resistance only predicts NIDDM in individuals with a low acute insulin response [8,9,81,[88][89][90], even in extremely insulin-resistant populations such as the Pima Indians [89]. Furthermore, in prospective studies both insulin resistance [3, 4, 6, 8-10, 79, 81, 89-92], and markers of insulin resistance such as obesity [7,9,10,81,82,[88][89][90][91][92][93][94][95][96][97][98][99][100], abdominal fat distribution [4,6,89,94], physical inactivity [80,81,95,97,99], a low sex-hormone-binding globulin concentration [4,92] and macrovascular disease [81,90], as welt as insulin-secretory defects [5,8,9,81,88,89,91] have predicted NIDDM.…”

Section: Is There a Familial Or Genetic Defect In Insulin Action In Rmentioning

confidence: 99%

Role of insulin resistance in the pathogenesis of NIDDM

Yki‐Järvinen

1995

Diabetologia

115

View full text Add to dashboard Cite

Adding metformin versus insulin dose increase in insulin-treated but poorly controlled Type 2 diabetes mellitus: an open-label randomized trial

et al. 1998

View full text Add to dashboard Cite

To compare the effect of adding metformin to insulin therapy with a moderate increase in insulin dose alone in insulin-treated, poorly controlled Type 2 diabetic patients, 47 consecutive such patients (baseline daily dose >0.5 IU kg(-1) and HbA1c >8%) were openly randomized either to a combination of their previous insulin schedule plus metformin (2.55 g daily in three divided doses, n = 24) or to a moderate insulin dose increase (20% of baseline, n = 23). The patient status/biochemical profile was assessed at entry and at 4 months. Among those assigned to insulin + metformin, 18 took the drug. Upon an intention-to-treat basis, patients assigned to insulin dose increase had a statistically significant weight gain (1.16+/-1.9 vs 0.3+/-4.5 kg, p < 0.05). Patients assigned to the insulin + metformin regimen experienced a significantly greater fall in HbA1c (-1.87+/-2.16 vs 0.03+/-1.68%, p < 0.01), total cholesterol (-0.56+/-0.89 vs 0.14+/-0.72 mmol l(-1), p < 0.05) and LDL-cholesterol (-0.51+/-0.73 vs 0.19+/-0.6 mmol l(-1), p < 0.01). These data suggest that adding metformin to insulin in poorly controlled Type 2 DM patients offers an advantage in terms of glycaemic control and lipid plasma profile.

show abstract

Association of elevated fasting C-peptide level and increased intra-abdominal fat distribution with development of NIDDM in Japanese-American men

Cited by 110 publications

References 0 publications

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

Role of insulin resistance in the pathogenesis of NIDDM

Adding metformin versus insulin dose increase in insulin-treated but poorly controlled Type 2 diabetes mellitus: an open-label randomized trial

Contact Info

Product

Resources

About