Association of early maternal hypertriglyceridemia with pregnancy-induced hypertension

Chandi, Anadeep; Sirohiwal, Daya; Malik, Roopa

doi:10.1007/s00404-015-3706-1

Cited by 16 publications

(10 citation statements)

References 26 publications

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“…Such period of pregnancy can be considered as an anabolic state, due to the low requirements of the developing offspring [64, 65]. In contrast, we did not observe any variations in lipid profile during the last third of gestation, a period of accelerated breakdown of fat depots to satisfy fetal demands [66, 67]. In this regard, plasma cholesterol and LDL-c concentrations increased in the undernourished groups during the period comprising D7 to D14 of pregnancy, suggesting a certain level of fat mobilization may be needed to deal with the implantation process [68], yolk sac formation and the establishment of the chorio-allantoic placental circulation [69].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the high incidence of sclerotic processes in the decidual vascular bed only observed in the UNDERFED group could be linked to the high circulating levels of cholesterol observed in this group on D14. In this sense, lipid peroxides and oxygen radicals can alter endothelial cells, resulting in fibrin deposition in the vessel walls [67]. Consequently, the arterial sinuses system in the rabbit, which can be identified within this period of gestation [78] and is responsible to retain maternal blood flow and then supply it to fetal area could be altered, resulting in IUGR.…”

Section: Discussionmentioning

confidence: 99%

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Competition for Materno-Fetal Resource Partitioning in a Rabbit Model of Undernourished Pregnancy

et al. 2017

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The major goal of animal production is to obtain abundant and healthy meat for consumers. Maternal food restriction (MFR) is often applied in farms to reduce production costs. However, the suitability of MFR in livestock animals is questionable, as this management may compromise maternal fitness due to a severe negative energetic balance and can induce Intrauterine Growth Restriction (IUGR) and prenatal programming in the offspring. Here, we sought to determine, using pregnant rabbits, the consequences of MFR on maternal endocrine and metabolic status and conceptus development. Pregnant dams were distributed into three groups: CONTROL (ad libitum feeding throughout the entire pregnancy; mean pregnancy length being around 31 days), UNDERFED (50% MFR during the entire pregnancy) and EARLY-UNDERFED (50% MFR only during the preimplantation period, Days 0–7). Maternal leptin concentrations and glycemic and lipid profiles were determined throughout pregnancy, whilst conceptus development was assessed ex-vivo at Day 28. Placental parameters were determined by macroscopic and histological evaluations and apoptotic assessments (TUNEL and Caspase-3). The main results of the study showed that, despite MFR altered maternal plasma lipid concentration (P<0.05), there were no effects on maternal bodyweight, plasma leptin concentration or glycemic profile. Fetal crown-rump lengths were reduced in both undernourished groups (P<0.001), but a significant reduction in fetal weight was only observed in the UNDERFED group (P<0.001). Growth in both undernourished groups was asymmetrical, with reduced liver weight (P<0.001) and significantly increased brain: fetal weight-ratio (P<0.001) and brain: liver weight-ratio (P<0.001) when compared to the CONTROL group. A significant reduction in placental weight was only observed in the UNDERFED group (P<0.001), despite both undernourished groups showing higher apoptotic rates at decidua and labyrinth zone (P<0.05) than the CONTROL group. Thus, these groups evidenced signs of placental degeneration, necrosis and stromal collapse. In summary, MFR may encourage the mother to make strategic decisions to safeguard her metabolic status and fitness at the expense of growth reduction in the litter, resulting in enhanced apoptotic and pathological processes at placental level and IUGR.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Competition for Materno-Fetal Resource Partitioning in a Rabbit Model of Undernourished Pregnancy

et al. 2017

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“…It is well established that an atherogenic lipid profile and/or elevated homocysteine concentration measured in serum or plasma are a strong and independent risk factor for vascular disease [ 7 , 8 ]. Also the association of early maternal hypertriglyceridemia with pregnancy-induced hypertension is recognized [ 9 ]. Whether maternal lipid composition and homocysteine are also risk factors for prediction of preterm delivery through their vascular effects is still under debate [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review

Moayeri

Heida

Franx

et al. 2016

Arch Gynecol Obstet

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BackgroundIt is unknown whether an unfavorable (atherogenic) lipid profile and homocysteine level, which could supersede clinical cardiovascular disease, is also associated with an increased risk of spontaneous preterm delivery (sPTD). A systematic review of studies assessing the lipid profile and homocysteine value of women with sPTD compared to women with term delivery in pre-pregnancy and during pregnancy.MethodsA systematic search of peer-reviewed articles published between January 1980 and May 2014 was performed using MEDLINE, EMBASE and the Cochrane database. We included case–control and cohort studies that examined triglycerides, high/low density lipoprotein cholesterol, total cholesterol and homocysteine in women with sPTD. Articles were subdivided in pre-pregnancy, first, second and third trimester. Of 708 articles reviewed for eligibility, 14 met our inclusion criteria.Results and conclusionNine cohort studies and five case–control studies were analyzed, reporting on 1466 cases with sPTD and 11296 controls with term delivery. The studies suggest a possible elevated risk of sPTD in woman with high TG levels, no association of high and low density lipoprotein cholesterol with the risk of sPTD was found. High homocysteine levels are associated with sPTD in the second trimester. The role of triglycerides and homocysteine in sPTD should be explored further.

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“…The excessive consumption of fat and sugar, usually described as the westernised lifestyle, has contributed to the growing incidence of metabolic disorders such as dyslipidaemia and type 2 diabetes (3) . It has been established that metabolic disorders, especially during pregnancy and early life, enhance susceptibility to the development of cardiometabolic diseases (4)(5)(6)(7) . For example, offspring from dams exposed to a high-fat diet during pregnancy exhibit hypertension and metabolic alterations in adult life (8,9) .…”

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confidence: 99%

Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

et al. 2017

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The present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0·04 %), were recorded from awake 90-d-old male offspring. DLP dams exhibited raised serum levels of total cholesterol (TC) (4·0-fold), TAG (2·0-fold), VLDL+LDL (7·7-fold) and reduced HDL-cholesterol (2·4-fold), insulin resistance and hepatic steatosis at the end of lactation. At 30 d of age, the DLP offspring showed an increase in the serum levels of TC (P<0·05) and VLDL+LDL (P<0·05) in comparison with CTL offspring. At 90 d of age, DLP offspring exhibited higher mean arterial pressure (MAP, approximately 34 %). In the spectral analysis, the DLP group showed augmented low-frequency (LF) power and LF:high-frequency (HF) ratio when compared with CTL offspring. In addition, the DLP animals showed a larger delta variation in arterial pressure after administration of the ganglionic blocker (P=0·0003). We also found that cardiorespiratory response to hypercapnia and hypoxia was augmented in DLP offspring. In conclusion, the present data show that maternal dyslipidaemia alters cardiorespiratory physiology and may be a predisposing factor for hypertension at adulthood.

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Association of early maternal hypertriglyceridemia with pregnancy-induced hypertension

Abstract: Our study supports the evidence that early pregnancy hypertriglyceridemia is associated with an increased risk of PIH.

Cited by 16 publications

References 26 publications

Competition for Materno-Fetal Resource Partitioning in a Rabbit Model of Undernourished Pregnancy

Competition for Materno-Fetal Resource Partitioning in a Rabbit Model of Undernourished Pregnancy

Maternal lipid profile and the relation with spontaneous preterm delivery: a systematic review

Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring

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