Association of dyslipidemia, diabetes and metabolic syndrome with serum ferritin levels: a middle eastern population-based cross-sectional study

Akl, Neyla S. Al; Khalifa, Olfa; Errafii, Khaoula; Arredouani, Abdelilah

doi:10.1038/s41598-021-03534-y

Cited by 15 publications

(11 citation statements)

References 32 publications

(38 reference statements)

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“…Moreover, even though it did not reach statistical significance, probably because of the sample size, we found an increase in PLR in prediabetic subjects, and we found a significant increase in PLR in diabetic patients compared with controls; furthermore, this parameter was associated with HbA1c and HOMA-IR in the simple regression analysis. This observation is consistent with previous studies in different populations and suggests that prediabetes is a proinflammatory condition [ 46 , 47 ]. Our group previously explored this hypothesis, demonstrating an impaired inflammatory profile in subjects with early glucose intolerance status and metabolic syndrome [ 6 , 48 ].…”

Section: Discussionsupporting

confidence: 94%

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Marco

Urbano

Filippello

et al. 2022

JCM

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Alterations of glucose homeostasis are associated with subclinical vascular damage; however, the role of platelet reactivity in this process has not been fully investigated. In this cross-sectional study, we evaluated the correlation between markers of platelet reactivity and inflammation and markers of vascular disease in subjects with prediabetes. Markers of platelet reactivity such as 11-dehydro-thromboxane B2 urinary levels (11-dh-TXB2) and mean platelet volume (MPV) and inflammatory indexes such as platelet-to-lymphocyte ratio (PLR) were evaluated in subjects with prediabetes (n = 48), new-onset type 2 diabetes (NODM, n = 60) and controls (n = 62). Furthermore, we assessed the cardiovascular risk profile of the study population with arterial stiffness and quality intima–media thickness (qIMT). Subjects with prediabetes and NODM exhibited higher 11-dh-TXB2 urinary levels and MPV and a proinflammatory profile with an increased PLR, high-sensitivity C-reactive protein, ferritin and fibrinogen. Furthermore, after multiple regression analyses, we found that urinary 11-dh-TXB2 was one of the major determinants of IMT and arterial stiffness parameters. In conclusion, subjects with prediabetes exhibit increased platelet reactivity as well as a proinflammatory profile. Furthermore, this condition is associated with early markers of cardiovascular disease.

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Section: Discussionsupporting

confidence: 94%

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Marco

Urbano

Filippello

et al. 2022

JCM

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“…This study demonstrated a significant association in increased ferritin levels with higher lipid levels and the risk of dyslipidemia, independent of confounding factors, such as age, gender, and lifestyle factors, which is consistent with previous studies in several countries [ 12 , 22 , 23 ]. However, the mechanism driving the relationship of circulatory ferritin with lipid metabolism is not fully understood.…”

Section: Discussionsupporting

confidence: 93%

Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents

Wang

Zhu

et al. 2022

IJERPH

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Objective: This study examined the association between serum ferritin and dyslipidemia in children and adolescents with different degrees of obesity. Method: In this multi-stage, stratified, randomized, sampling cross-section cohort study, demographic data were collected by questionnaire from 4320 children and adolescents (aged 6–17 years) in Shanghai, China. Anthropometric measures and percent body fat (PBF) were recorded. Serum lipid parameters were detected by an automatic biochemical method, and ferritin levels were measured by an automatic immunoassay. Results: Our results showed 70.6%, 13.9%, and 15.5% of participants had a healthy body fat, low fat, and overweight/obese, respectively. Increasing ferritin quartiles were independently associated with a greater hazard of dyslipidemia, especially in overweight/obese participants, and the OR (95% CI) was 3.01 (1.29–7.00), 3.58 (1.59–8.04), and 5.66 (2.57–12.46) across the ferritin quartiles after adjustment for confounders. Ferritin was only a predictive value for dyslipidemia in overweight/obese participants (AUC = 0.64) and was consistent in boys (AUC = 0.61) and girls (AUC = 0.68). The significant positive correlation between ferritin value and lipid abnormalities profiles (except for low HDL-C) mainly appeared in the overweight/obesity group. Conclusion: The results showed that serum ferritin can be considered an independent risk factor for dyslipidemia in children and adolescents with obesity. Highlights: Ferritin overload had a greater risk of dyslipidemia, especially in children and adolescents with overweight/obesity.

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“…In our study, it was observed that the patients with higher ferritin levels were suffered from more metabolism disorders that included dyslipidemia and hypertension. Several previous studies have indicated the similar results that increased ferritin levels are associated with disrupted lipid metabolism in T2DM ( 24 – 26 ). Higher serum iron levels, TSAT levels, and hs-CRP levels are found in the patients with the highest tertile of ferritin levels.…”

Section: Discussionsupporting

confidence: 69%

Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus

et al. 2022

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BackgroundOur study aimed to investigate the association between iron metabolism and body composition in patients with type 2 diabetes mellitus (T2DM).MethodsA total of 824 patients with T2DM were enrolled. Measurements of body composition were obtained by dual-energy X-ray absorptiometry. Patients were stratified into three groups according to their sex-specific ferritin levels. Basic information, laboratory results, and body composition were collected.ResultsSerum iron and transferrin saturation (TSAT) were increased significantly with increased serum ferritin (all p < 0.05). Total iron-binding capacity (TIBC) was decreased significantly with increased serum ferritin (p < 0.05). Visceral fat mass (VF), android fat/total body fat mass, android-to-gynoid fat ratio (A/G ratio), and high-sensitivity C-reactive protein were all increased significantly with increased serum ferritin (all p < 0.05). Patients with a high A/G ratio (A/G ratio ≧ 1) had significantly higher serum iron, ferritin, and TSAT, but significantly lower TIBC. In the model adjusted for age and gender, higher ferritin levels were associated with a higher VF (all p < 0.05). Serum iron was positively correlated with the occurrence of a high A/G ratio (A/G ratio ≧ 1) after the adjustment of confounding factors [an odds ratio (OR = 1.09, 95% CI, 1.02–1.19, p = 0.02)]. With receiver operating curve analysis, the cutoff value of serum iron for a high A/G ratio was 18.56, and the area under the curve was 0.771 (sensitivity 88.9%and specificity 63.9%, p = 0.01).ConclusionHigher serum iron and ferritin concentrations were positively associated with a higher VF. Higher serum iron concentrations were positively correlated with a high A/G ratio. This study indicates the potential relationship between iron overload and the body composition in patients with T2DM.

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Association of dyslipidemia, diabetes and metabolic syndrome with serum ferritin levels: a middle eastern population-based cross-sectional study

Cited by 15 publications

References 32 publications

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents

Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus

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