Association of DRB1 and DQB1 HLA Class II Polymorphisms in High-Grade and Neoplastic Cervical Lesions of Women From Argentina

Eiguchi, Kumiko; Tatti, Sílvio; Alonio, Lidia Virginia; González, Joaquín V.; Leirós, Gustavo José; Fleider, Laura; Vighi, Susana; Padros, Karin; Raimondi, Eduardo; Teyssié, Angélica R.; Picconi, Marı́a Alejandra

doi:10.1097/lgt.0b013e3181729285

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Whether the amount of sHLA-G production and magnitude of HLA-G membrane expression or the balance between HLA molecules on the cervical cell surface that produce inhibitory or stimulatory signals for NK cells is necessary to modulate the outcome of the infection are questions that need to be further explored. Although other HLA class I and class II classical genes have been associated with SIL, [44][45][46][47] the results of the present study indicate that HLA-G polymorphisms as well as the HPV type are associated with SIL. To clarify the function of HLA-G alleles in SIL susceptibility, it would be interesting to conduct a longitudinal study on normal women exhibiting HPV infection with no SIL to determine whether these alleles are associated with elimination or persistence of HPV infection.…”

Section: Hla-g In Patients Stratified According To Lesion Severity Anmentioning

confidence: 57%

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

et al. 2009

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Human papillomavirus (HPV) infection is etiologically associated with low-(LSIL) and high-grade squamous intraepithelial lesions (HSIL) and with cervical cancer. The progression or regression of the lesions may depend, among other factors, on the host heritable immune response. Because human leukocyte antigen (HLA)-G molecules are involved in the modulation of innate and adaptive immune responses, and because no previous studies have evaluated HLA-G polymorphism in patients with SIL, we conducted a study to assess the association between HLA-G polymorphisms and cervical lesions harboring HPV infection. Cervico-vaginal scrapings and blood samples were collected from 125 women with SIL (68 LSIL and 57 HSIL) and from 94 healthy women without HPV infection and cytological abnormalities. HPV type and HLA-G polymorphisms in exons 2, 3 and 8 (14 bp insertion/deletion) were evaluated by PCR methodology, and digested with restriction endonucleases. The Genepop software and the EM and PHASE algorithms were used for statistical analysis. A significant protective association was observed between the presence of the G*0103 allele and SIL and between the G0101/G0104 genotype and HSIL in the group of patients compared to control. The presence of the G0104/ þ 14 bp and G0104/À14 bp haplotypes conferred susceptibility to SIL compared to control. In addition, patients possessing the G0104/ þ 14 bp haplotype and harboring HPV-16 and -18 co-infections were particularly associated with HSIL. These findings suggest that HLA-G polymorphisms may be associated with HPV infection and SIL, consequently representing a profile of predisposition to cervical cancer.

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Section: Hla-g In Patients Stratified According To Lesion Severity Anmentioning

confidence: 57%

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

et al. 2009

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“…[36][37][38] However, information about variation in immune system genes (HLA, cytokines) is still scarce. 39 In this work, our association study shows that individuals carrying TNF␣-307A allele were more frequently members of the case group (21.5%) than the control group (10.6%), at an OR value of 2.4 (CI 95% 1. 1-5.4).…”

Section: Discussionmentioning

confidence: 92%

“…45 Studies of HLA distributions in Argentinean women show that HLA-DRB1*04 and HLA-DQB1*0302 are risk factors for malignant progression, whereas HLADRB1*13 and HLA-DQB1*02 have a protective effect. 39 Based on these observations, it will be necessary to extend our study to the evaluation of HLA alleles in linkage disequilibrium with the described TNF-␣ SNPs. This paper is the first report of TNF␣ SNP variation in Misiones, and will contribute to the characterization of immunological genetic markers in Argentina.…”

Section: Discussionmentioning

confidence: 95%

Analysis of TNFα promoter SNPs and the risk of cervical cancer in urban populations of Posadas (Misiones, Argentina)

Badano¹,

Stietz²,

Schurr³

et al. 2012

Journal of Clinical Virology

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“…Susceptibility to HPV infection or cervical cancer and precancerous lesion development was associated with the HLA class II: HLA-DRB1 alleles [34, 39–51]; HLA-DQB1 alleles [34, 39, 46, 49–51]; HLA-DPB1 alleles [51]; and classes I and II haplotypes [30, 34, 40–42, 48, 52, 53]. Some alleles and haplotypes had a protective effect against the progression to infection and cancer [34, 38–40, 43, 46, 47, 51, 54, 55]. In general, HLA-DQB1∗03 increases and DRB1∗13 decreases the risk of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Marangon

Guelsin

Visentainer

et al. 2013

BioMed Research International

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The genetic variability of the host contributes to the risk of human papillomavirus (HPV)-related cervical disease. Immune response genes to HPV must be investigated to define patients with the highest risk of developing malignant disease. The aim of this study was to investigate the association of polymorphic immune response genes, namely KIR, HLA class I and II, and single-nucleotide polymorphisms (SNPs) of cytokines with HPV-related cervical disease. We selected 79 non-related, admixed Brazilian women from the state of Paraná, southern region of Brazil, who were infected with high carcinogenic risk HPV and present cervical intraepithelial neoplasia grade 3 (CIN3), and 150 HPV-negative women from the same region matched for ethnicity. KIR genes were genotyped using an in-house PCR-SSP. HLA alleles were typed using a reverse sequence-specific oligonucleotide technique. SNPs of TNF −308G>A, IL6 −174G>C, IFNG +874T>A, TGFB1 +869T>C +915G>C, and IL10 −592C>A −819C>T −1082G>A were evaluated using PCR-SSP. The KIR genes were not associated with HPV, although some pairs of i(inhibitory)KIR-ligands occurred more frequently in patients, supporting a role for NK in detrimental chronic inflammatory and carcinogenesis. Some HLA haplotypes were associated with HPV. The associations of INFG and IL10 SNPs potentially reflect impaired or invalid responses in advanced lesions.

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Association of DRB1 and DQB1 HLA Class II Polymorphisms in High-Grade and Neoplastic Cervical Lesions of Women From Argentina

Cited by 9 publications

References 33 publications

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

Analysis of TNFα promoter SNPs and the risk of cervical cancer in urban populations of Posadas (Misiones, Argentina)

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

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