Association of disease duration and sensorimotor function in type 2 diabetes mellitus: beyond diabetic peripheral neuropathy

Khan, Neha; Ahmad, Irshad; Noohu, Majumi M.

doi:10.1080/08990220.2020.1830757

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…The sensorimotor network plays an important role in motor control and sensory function. Previous studies demonstrated that diabetic peripheral neuropathy patients were associated with sensorimotor dysfunction ( Khan et al, 2020 ; Van Eetvelde et al, 2020 ). Zhang et al (2020) demonstrated that diabetic peripheral neuropathy patients had abnormal gray matter in pre- and PosCG relative to health controls.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Interhemispheric Functional Connectivity in Diabetic Retinopathy Patients

2021

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Background: Accumulating lines of evidence demonstrated that diabetic retinopathy (DR) patients trigger abnormalities in brain’s functional connectivity (FC), whereas the alterations of interhemispheric coordination pattern occurring in DR are not well understood. Our study was to investigate alterations of interhemispheric coordination in DR patients.Methods: Thirty-four DR individuals (19 males and 15 females: mean age: 52.97 ± 8.35 years) and 37 healthy controls (HCs) (16 males and 21 females; mean age: 53.78 ± 7.24 years) were enrolled in the study. The voxel-mirrored homotopic connectivity (VMHC) method was conducted to investigate the different interhemispheric FC between two groups. Then, the seed-based FC method was applied to assess the different FCs with region of interest (ROI) in the brain regions of decreased VMHC between two groups.Results: Compared with HC groups, DR groups showed decreased VMHC values in the bilateral middle temporal gyrus (MTG), lingual/calcarine/middle occipital gyrus (LING/CAL/MOG), superior temporal gyrus (STG), angular (ANG), postcentral gyrus (PosCG), inferior parietal lobule (IPL), and precentral gyrus (PreCG). Meanwhile, altered FC includes the regions of auditory network, visual network, default mode network, salience network, and sensorimotor network. Moreover, a significant positive correlation was observed between the visual acuity-oculus dexter (OD) and zVMHC values in the bilateral LING/CAL/MOG (r = 0.551, p = 0.001), STG (r = 0.426, p = 0.012), PosCG (r = 0.494, p = 0.003), and IPL (r = 0.459, p = 0.006) in DR patients.Conclusion: Our results highlighted that DR patients were associated with substantial impairment of interhemispheric coordination in auditory network, visual network, default mode network, and sensorimotor network. The VMHC might be a promising therapeutic target in the intervention of brain functional dysfunction in DR patients.

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Section: Discussionmentioning

confidence: 99%

Aberrant Interhemispheric Functional Connectivity in Diabetic Retinopathy Patients

2021

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“…Numerous studies have highlighted that the length of time a patient has had T2DM, combined with DPN ( 13 – 16 ), is a crucial determinant. As the duration of diabetes increases, the likelihood of developing DPN also rises.…”

Section: Discussionmentioning

confidence: 99%

“…As the duration of diabetes increases, the likelihood of developing DPN also rises. Notably, individuals who have had T2DM for five years or more tend to experience gradual declines in their vibration perception threshold, reaction time, and balance ( 13 ). A particular cross-sectional study underscored a notable positive correlation between the length of diabetes and the prevalence of DPN, suggesting that DPN progression is closely tied to how long one has had diabetes, typically spanning 8 to 16 years ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a risk nomogram model for predicting peripheral neuropathy in patients with type 2 diabetes mellitus

Luo,

Long,

Cheng

et al. 2024

Front. Endocrinol.

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ObjectiveDiabetic peripheral neuropathy frequently occurs and presents severely in individuals suffering from type 2 diabetes mellitus, representing a significant complication. The objective of this research was to develop a risk nomogram for DPN, ensuring its internal validity and evaluating its capacity to predict the condition.MethodsIn this retrospective analysis, Suqian First Hospital’s cohort from January 2021 to June 2022 encompassed 397 individuals diagnosed with T2DM. A random number table method was utilized to allocate these patients into two groups for training and validation, following a 7:3 ratio. By applying univariate and multivariable logistic regression, predictive factors were refined to construct the nomogram. The model’s prediction accuracy was assessed through metrics like the ROC area, HL test, and an analysis of the calibration curve. DCA further appraised the clinical applicability of the model. Emphasis was also placed on internal validation to confirm the model’s dependability and consistency.ResultsOut of 36 evaluated clinicopathological characteristics, a set of four, duration, TBIL, TG, and DPVD, were identified as key variables for constructing the predictive nomogram. The model exhibited robust discriminatory power, evidenced by an AUC of 0.771 (95% CI: 0.714-0.828) in the training cohort and an AUC of 0.754 (95% CI: 0.663-0.845) in the validation group. The congruence of the model’s predictions with actual findings was corroborated by the calibration curve. Furthermore, DCA affirmed the clinical value of the model in predicting DPN.ConclusionThis research introduces an innovative risk nomogram designed for the prediction of diabetic peripheral neuropathy in individuals suffering from type 2 diabetes mellitus. It offers a valuable resource for healthcare professionals to pinpoint those at elevated risk of developing this complication. As a functional instrument, it stands as a viable option for the prognostication of DPN in clinical settings.

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“…However, it is also possible that there are some different mechanisms between middle‐aged and older adults. For example, balance impairment in older adults is often considered a consequence of geriatric syndrome, whereas balance impairment in middle‐aged adults may often be due to certain diseases such as diabetic peripheral neuropathy 27 . More research is needed in the future to explore the physiological mechanisms underlying the occurrence of disability in middle‐aged and older adults.…”

Section: Discussionmentioning

confidence: 99%

Association between subjective cognitive complaints, balance impairment and disability among middle‐aged and older adults: Evidence from a population‐based cohort study

Wang

et al. 2022

Geriatrics Gerontology Int

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Aim To quantify the association between subjective cognitive complaints and balance impairment in relation to the occurrence of disability. Methods In total, 6885 adults aged ≥45 who participated in the China Health and Retirement Longitudinal Study (CHARLS) were followed for 7 years. Subjective cognitive complaints were evaluated by self‐reported memory problems. Balance impairment was tested by side‐by‐side stand, semi‐tandem stand and full tandem stand. Disability was measured by activities of daily living (ADL) and instrumental activities of daily living (IADL). Multivariate logistic regression models were applied to test the joint effect between baseline subjective cognitive complaints and balance impairment on disability. The multiplicative interaction was examined. Results A joint effect of experiencing both subjective cognitive complaints and balance impairment was identified, showing a 1.63‐fold higher risk of ADL and IADL disability than those experienced by neither of the two (odds ratio = 1.63, 95% confidence interval: 1.36–1.95). There was evidence of multiplicative interaction (P = 0.004). Conclusions Among middle‐aged and older people, the coexistence of subjective cognitive complaints and balance impairment may lead to a higher disability risk, which is much higher than the simple sum of the two individual effects. Future interventions are required to target these symptoms simultaneously to reduce the risks of disability. Geriatr Gerontol Int 2022; 22: 1025–1031.

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Association of disease duration and sensorimotor function in type 2 diabetes mellitus: beyond diabetic peripheral neuropathy

Cited by 6 publications

References 37 publications

Aberrant Interhemispheric Functional Connectivity in Diabetic Retinopathy Patients

Aberrant Interhemispheric Functional Connectivity in Diabetic Retinopathy Patients

Development and validation of a risk nomogram model for predicting peripheral neuropathy in patients with type 2 diabetes mellitus

Association between subjective cognitive complaints, balance impairment and disability among middle‐aged and older adults: Evidence from a population‐based cohort study

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